Results 81 to 90 of about 1,307,802 (305)

Kinetics of 15 per- and polyfluoroalkyl substances (PFAS) after single oral application as a mixture – A pilot investigation in a male volunteer

Environment International
Per- and polyfluoroalkyl substances (PFAS) are ubiquitous environmental contaminants with half-lives in humans in the range of years in case of the long-chain compounds, leading to accumulation and measurable levels in plasma.
Klaus Abraham, Helena Mertens, Lennart Richter, Hans Mielke, Tanja Schwerdtle, Bernhard H. Monien   +5 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

An exposure assessment of a laboratory assistant to hazardous chemical substances

, 2009
A survey was conducted to measure exposure to hazardous chemical substances of a laboratory assistant working in a university laboratory, who complained of symptoms that could be indicative of chemical absorption.
Laubscher, Petrus J., Van Aarde, Michiel Nico, Franken, Anja, Eloff, Frederik C., Du Plessis, Johan L.   +4 more
core  

Understanding community insights on waste segregation and environmental health using a photovoice based crowdsourcing approach in India

Discover Social Science and Health
Increasing amount of municipal solid waste is a growing global concern harming the health of the humans and animals and affecting the sustainability of the environment. While citizens are expected to take responsibility for waste sorting and segregation,
Madhanraj Kalyanasundaram, Manju Yadav, Kavya Krishnan, Surya Singh, Rachna Soni, Krushna Chandra Sahoo, Ashish Pathak, Salla Atkins, Cecilia Stålsby Lundborg, Kamran Rousta, Vishal Diwan   +10 more
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Quantitative exposure assessment in community-based studies

, 2012
Occupational epidemiology focuses on the associations between exposures at the workplace and disease outcomes, essentially concerned with the prevention of disease.
Peters, S.M., Dep IRAS, Risk Assessment of Toxic and Immunomodulatory Agents   +2 more
core  

Metabolomic profiling reveals systemic metabolic disruptions induced by combined exposure to particulate matter and ozone

Current Research in Toxicology
Air pollution exposure, especially particulate matter (PM) and ozone (O3), poses significant health risks, but the systemic metabolic consequences of combined exposures to PM and O3, remain poorly understood.
Yue Ge, Maliha S. Nash, Aimen K. Farraj
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Exposure Assessment Program (EXAP) [PDF]

The Exposure Assessment Program provides national and international leadership in the development and use of effective exposure assessment strategies and methods to prevent work-related illness and injury.

core  

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source