Results 101 to 110 of about 1,307,802 (305)

Exposure and risk assessment of dioxins and PCBs in humans

, 2010
The research described in this thesis was conducted to address health risks associated with occupational exposure to chlorophenoxy herbicides and dioxins (especially TCDD), with a special focus on specific health outcomes (cause specific mortality and ...
Dep IRAS, Boers, D., Risk Assessment of Toxic and Immunomodulatory Agents   +2 more
core  

Advanced REACH tool:a Bayesian model for occupational exposure assessment

, 2014
This paper describes a Bayesian model for the assessment of inhalation exposures in an occupational setting; the methodology underpins a freely available web-based application for exposure assessment, the Advanced REACH Tool (ART).
Van Tongeren, Martie; id_orcid, McNally, K., Fransman, Wouter, Tielemans, Erik, Warren, N., Risk Assessment of Toxic and Immunomodulatory Agents, Entink, Rinke Klein, Schneider, Thomas, Warren, Nicholas, IRAS RATIA2, LS IRAS EEPI EXAS (Arb.hyg+bl.st.kar.), Schinkel, J., Schneider, T., Cherrie, J.W., Cherrie, John W., Cherrie, John W.; id_orcid, Van Tongeren, M., Schinkel, Jody, Kromhout, Hans, Kromhout, H., McNally, Kevin, Tielemans, E., Van Tongeren, Martie, Fransman, W., Entink, R.K.   +24 more
core   +1 more source

exposure assessment

Citation: 'exposure assessment' in the IUPAC Compendium of Chemical Terminology, 5th ed.; International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. 10.1351/goldbook.14673 • License: The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International for individual terms.
  +4 more sources

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

beta-(1,3)-Glucan exposure assessment by passive airborne dust sampling and new sensitive immunoassays.

, 2010
Associations between house dust-associated beta-(1,3)-glucan exposure and airway inflammatory reactions have been reported, while such exposures in early childhood have been suggested to protect against asthma and wheezing.
Metwali, N., Thorne, P.S., Dep IRAS, Sander, I., Doekes, G., Bezemer, G., Raulf-Heimsoth, M., Heederik, D.J.J., Risk Assessment of Toxic and Immunomodulatory Agents, Wouters, I.M., Noss, I.   +10 more
core   +1 more source

Modification of associations between ambient PM2.5 and vital signs by β-blocker prescription status among individuals with heart failure

Environmental Health
Background Fine particulate matter (PM2.5) is associated with cardiovascular morbidity, especially among individuals with pre-existing cardiovascular conditions, such as heart failure (HF).
Morgan Narain, Miyuki Breen, Alex P. Carll, Mehdi Hazari, Aimen Farraj, Cavin K. Ward-Caviness   +5 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Cross-validation and refinement of the Stoffenmanager as a first tier exposure assessment tool for REACH.

, 2010
OBJECTIVES: For regulatory risk assessment under REACH a tiered approach is proposed in which the first tier models should provide a conservative exposure estimate that can discriminate between scenarios which are of concern and those which are not.
Schinkel, J., Tielemans, E., Dep IRAS, Fransman, W., Heussen, H., Risk Assessment of Toxic and Immunomodulatory Agents, Marquart, H., Kromhout, H.   +7 more
core   +1 more source

Cocktail effects of clothianidin and imidacloprid in zebrafish embryonic development, with high and low concentrations of mixtures

Frontiers in Toxicology
There is growing concern that sprayed neonicotinoid pesticides (neonics) persist in mixed forms in the environmental soil and water systems, and these concerns stem from reports of increase in both the detection frequency and concentration of these ...
Seonggeun Zee, Seonggeun Zee, Seonggeun Zee, Moonjung Hyun, Hee-Jung Sim, Kanghee Kim, Ju-Chan Kang, Chang-Beom Park   +7 more
doaj   +1 more source