Results 101 to 110 of about 7,091,564 (299)

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Microbial components in house dust : exposure assessment and immunologic characterization [PDF]

, 2010
According to the “hygiene hypothesis” the rising numbers of people suffering from allergies and asthma may be associated with changes in modern lifestyle including the improvement of living and household standards as well as personal hygiene.
Dep IRAS, Risk Assessment of Toxic and Immunomodulatory Agents, Noss, I.   +2 more
core   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

A model for probabilistic health impact assessment of exposure to food chemicals. [PDF]

, 2009
A statistical model is presented extending the integrated probabilistic risk assessment (IPRA) model of van der Voet and Slob [van der Voet, H., Slob, W., 2007.
van der Heijden, G.W.A.M., Dep IRAS, Bosgra, S., Muri, S.D., van der Voet, H., Bruschweiler, B.J., Bos, P.M.J., Risk Assessment of Toxic and Immunomodulatory Agents, van der Heijden, G.W., Boon, P.E.   +9 more
core   +1 more source

Global Burden of Disease of Mercury Used in Artisanal Small-Scale Gold Mining

Annals of Global Health, 2017
Background: Artisanal small-scale gold mining (ASGM) is the world's largest anthropogenic source of mercury emission. Gold miners are highly exposed to metallic mercury and suffer occupational mercury intoxication.
Nadine Steckling, Myriam Tobollik, Dietrich Plass, Claudia Hornberg, Bret Ericson, Richard Fuller, Stephan Bose-O'Reilly   +6 more
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

beta-(1,3)-Glucan exposure assessment by passive airborne dust sampling and new sensitive immunoassays. [PDF]

, 2010
Associations between house dust-associated beta-(1,3)-glucan exposure and airway inflammatory reactions have been reported, while such exposures in early childhood have been suggested to protect against asthma and wheezing.
Metwali, N., Thorne, P.S., Dep IRAS, Sander, I., Doekes, G., Bezemer, G., Raulf-Heimsoth, M., Heederik, D.J.J., Risk Assessment of Toxic and Immunomodulatory Agents, Wouters, I.M., Noss, I.   +10 more
core   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Cross-validation and refinement of the Stoffenmanager as a first tier exposure assessment tool for REACH. [PDF]

, 2010
OBJECTIVES: For regulatory risk assessment under REACH a tiered approach is proposed in which the first tier models should provide a conservative exposure estimate that can discriminate between scenarios which are of concern and those which are not.
Schinkel, J., Tielemans, E., Dep IRAS, Fransman, W., Heussen, H., Risk Assessment of Toxic and Immunomodulatory Agents, Marquart, H., Kromhout, H.   +7 more
core   +1 more source