Results 171 to 180 of about 3,965,960 (305)

Exposure response – getting the dose right [PDF]

Pharmaceutical Statistics, 2009
José, Pinheiro, Stephen, Duffull
openaire   +2 more sources

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Do Dropouts Benefit from Training Programs? Korean Evidence Employing Methods for Continuous Treatments [PDF]

Failure of participants to complete training programs is pervasive in existing active labor market programs both in developed and developing countries. The proportion of dropouts in prototypical programs ranges from 10 to 50 percent of all participants ...
Lee, Sang-Jun, Choe, Chung, Flores-Lagunes, Alfonso   +2 more
core  

Exposure dose-dependent multi-tone photolithography via photoacid-induced crosslinking and degradation of poly(2,3-dihydrofuran). [PDF]

Nat Commun
Huang JD, Tan X, Liu J, Zhao B, Li HQ, Ren YY, Tian R, Xiong Y, Li C, Wang MK, Xiang SL, Zhu MQ.   +11 more
europepmc   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

The Fluoroscopy Paradox: Radiation Exposure, Dose Optimization, and Occupational Risk in Full-Endoscopic and Biportal Spine Surgery-A Narrative Review. [PDF]

J Clin Med
Kim DH, Hong JT, Hur JW.
europepmc   +1 more source

Exposure Planned Dose [PDF]

, 2020
openaire   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Criteria for a Recommended Standard: NEG and NIOSH Basis for an Occupational Health Standard: Ethyl Ether

"Possible health hazards resulting from occupational exposure to ethyl-ether (60297) were reviewed and discussed. Topics included physical properties, chemical properties, industrial uses, occupational exposures, toxicokinetics, acute toxicity ...

core  

Nonparametric Estimators of Dose-Response Functions [PDF]

We propose two semiparametric estimators of the dose-response function based on spline techniques. Under uncounfoundedness, the generalized propensity score can be used to estimate dose-response functions (DRF) and marginal treatment effect functions. In
MATTEI Alessandra, FLORES Carlos A., BIA Michela   +2 more
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