Results 71 to 80 of about 3,965,960 (305)
Pediatric Blood &Cancer, EarlyView.ABSTRACT Central nervous system (CNS) relapse of neuroblastoma carries a poor prognosis, and craniospinal irradiation (CSI) poses substantial long‐term toxicity in young children. We report a toddler with MYCN‐amplified neuroblastoma harboring somatic ALK R1275Q who developed extensive leptomeningeal relapse with paraplegia.
Jinwoo Kim +11 more
wiley +1 more source
Dose-Response Relationships in Human Experimental Exposure to Solvents
, 2006 Previous studies carried out in the field of experimental toxicology have shown evidence of biphasic dose-response relationships for different experimental models, end-points and chemicals tested.
Giovanni Carelli +2 more
core +1 more source
Assessment of Effective Dose Equivalent from Internal Exposure to 222Rn in Ramsar City [PDF]
Iranian Journal of Medical Physics, 2015 Introduction In this study, effective dose equivalent for the public due to internal exposure to 222radon (222Rn) was evaluated in three regions of Ramsar, a northern coastal city in Iran. Materials and Methods Measurements
Tayyeb Allahverdi Pourfallah +2 more
doaj +1 more source
Low-dose Radiation Exposure and Carcinogenesis [PDF]
Japanese Journal of Clinical Oncology, 2012 Absorption of energy from ionizing radiation by the genetic material in the cell leads to damage to DNA, which in turn leads to cell death, chromosome aberrations and gene mutations. While early or deterministic effects result from organ and tissue damage caused by cell killing, latter two are considered to be involved in the initial events that lead ...
Keiji, Suzuki, Shunichi, Yamashita
openaire +3 more sources
Therapeutic Apheresis and Dialysis, EarlyView.ABSTRACT Introduction This final analysis of a multicenter, prospective postmarketing surveillance study evaluated the safety of daprodustat in patients with chronic kidney disease anemia in routine clinical practice in Japan. Methods Patients who initiated daprodustat between September 2020 and July 2022 were registered.
Tadao Akizawa +7 more
wiley +1 more source
FEBS Letters, EarlyView.Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi +5 more
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Evaluation of Exposure Dose for Panoramic Radiography
Japanese Journal of Radiological Technology, 2009 There is no established method to determine a diagnostic reference level of panoramic radiology. As the basic principle of the panoramic radiology dose index (PRDI) and CT dose index (CTDI) is almost identical, we evaluated the usefulness of PRDI for this purpose.Using the imaging plate (IP) sandwiched between the 160-mm thick acrylic disks, horizontal
Hoshino, Yoshihiko +5 more
openaire +2 more sources
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Exposure Dose Guidance for Dermal and Ingestion Exposure to Surface Water [PDF]
EDG for Dermal and Ingestion Exposure to Surface Water, V2 \u2013 Sept 25, 2018This exposure dose guidance (EDG) for surface water provides health assessors with updated guidance on how to estimate exposure from ingesting and contacting contaminants in ...
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