Results 61 to 70 of about 900,292 (307)

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Impacts of indoor surface finishes on bacterial viability. [PDF]

, 2019
Microbes in indoor environments are constantly being exposed to antimicrobial surface finishes. Many are rendered non-viable after spending extended periods of time under low-moisture, low-nutrient surface conditions, regardless of whether those surfaces
Ben Maamar, Sarah, Gilbert, Jack A, Glawe, Adam J, Gottel, Neil, Hartmann, Erica M, Hu, Jinglin   +5 more
core  

Laser-induced generation of singlet oxygen and its role in the cerebrovascular physiology [PDF]

, 2017
For over 55 years, laser technology has expanded from laboratory research to widespread fields, for example telecommunication and data storage amongst others.
Bragina, O. A., Gekaluyk, A. S., Goltsov, Alexey, Rafailov, E. U., Saranceva, E. I., Semyachkina-Glushkovskaya, O. V., Sokolovski, S. G., Tuchin, V. V.   +7 more
core   +2 more sources

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

COMPRENDO: Focus and approach [PDF]

, 2006
Tens of thousands of man-made chemicals are in regular use and discharged into the environment. Many of them are known to interfere with the hormonal systems in humans and wildlife.
Axel Allera, Candia Carnevali MD, Charles Tyler, Christoph van Ballegoy, Cinta Porte, Copeland BJ, Daniela Candia Carnevali, David Hala, Dietrich Klingmüller, European Parliament and the Council of the European Union, Francesca Ciceri, Gemma Janer, Ilka Lutz, Isabella King, Jean Bachmann, Jerzy Falandysz, Jörg Oehlmann, Kresten Ole Kusk, Leah Wollenberger, Marian Rand-Weaver, Michela Sugni, Nicola Beresford, Pia Berntsson, Ramon Levada, Roger Jeannot, Ronny van Aerle, Silvana Galassi, Stina Oredsson, Susan Jobling, Susan Lo, Tagatz ME, Thierry Dagnac, Triantafyllos Albanis, Ulrike Schulte-Oehlmann, Vasilis Sakkas, Werner Kloas   +35 more
core   +4 more sources

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Compatibility of Glyphosate with Galerucella calmariensis; a Biological Control Agent for Purple Loosestrife (Lythrum salicaria) [PDF]

, 1999
By integrating Galerucella calmariensis with glyphosate there is potential to achieve both immediate and sustained control of purple loosestrife (Lythrum salicaria).
Gabor, T. Shane, Lindgren, Cory John, Murkin, Henry R.   +2 more
core  

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source