Results 231 to 240 of about 12,227,621 (274)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

The postnatal expression of transcripts and proteins in the corpus callosum, as well as its myelinization, is affected by the congenital absence of AQP4. [PDF]

J Physiol Biochem
Mayo F, González-Vinceiro L, Hiraldo-González L, Torres-Rubio I, Calle-Castillejo C, Sobh-Doush E, Ramírez-Lorca R, Echevarría M.   +7 more
europepmc   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Blimp-1 integrates alarmin signals in ILC2s and drives proinflammatory functions required for type 2 immunity. [PDF]

J Exp Med
Forster PM, Preußer A, Yano H, Deshpande D, Zhang W, Kowalczyk A, Velleman L, Dubik MO, Uddin J, Emanuel ER, Leclère PS, Mertens R, Gao X, Kofoed-Branzk M, Hauser AE, Mittrücker HW, Diefenbach A, Artis D, Klose CSN.   +18 more
europepmc   +1 more source

Mediator subunit MED19 modulates elf18-induced <i>PR1</i> expression via TGA transcription factors. [PDF]

Plant Signal Behav
Um T, Lee GS, Seo JS.
europepmc   +1 more source

Paradoxical Expression of Ionotropic Glutamate Receptors in Leucocytes. [PDF]

Clin Rev Allergy Immunol
Clanchy FIL, Williams RO, Stone TW.
europepmc   +1 more source

The Significance of CXCL1 in Cancer: An Overview of Molecular Mechanisms. [PDF]

Int J Mol Sci
Korbecki J, Bosiacki M, Dzięciołowska-Baran E, Pawlik P, Lubkowski M, Walaszek I, Barczak K.   +6 more
europepmc   +1 more source

Multiomic analysis of clonal development reveals new regulators of leukemic cell growth. [PDF]

Genes Dev
Bonilla G, Morris A, Kundu S, DuCasse A, Kirkpatrick G, Milosevic J, Jeffries NE, Chetal K, Yvanovich EE, Zhao T, Xia J, Barghout R, Scadden D, Mansour MK, Kingston RE, Sykes DB, Mercier FE, Sadreyev RI.   +17 more
europepmc   +1 more source