Results 131 to 140 of about 33,209,906 (421)

Spectral analysis of Gene co-expression network of Zebrafish

, 2012
We analyze the gene expression data of Zebrafish under the combined framework of complex networks and random matrix theory. The nearest neighbor spacing distribution of the corresponding matrix spectra follows random matrix predictions of Gaussian ...
, B. Li, C. Y. Ung, Dehmer M., Gasch A. P., J. Bhojwani, Jalan S., L. Zhang, Liang W. S., Luo F., López-Maury L., Mehta M. L., S. H. Lan, S. Jalan, Spitsbergen J. M., Z. Gong, Zyczkowski K.   +16 more
core   +1 more source

Uncovering regulatory pathways that affect hematopoietic stem cell function using 'genetical genomics' [PDF]

, 2005
We combined large-scale mRNA expression analysis and gene mapping to identify genes and loci that control hematopoietic stem cell (HSC) function. We measured mRNA expression levels in purified HSCs isolated from a panel of densely genotyped recombinant ...
A Scherer, CE Muller-Sieburg, CS Potten, EE Schadt, ES Lander, F Lai, G de Haan, G De Haan, G De Haan, G Yvert, J Boultwood, J Klose, JL Peirce, LM Kamminga, M Ramalho-Santos, ML Wayne, NB Ivanova, NO Fortunel, P Hasty, RB Brem, RC Jansen, RC Jansen, SR Pearce, T Wiltshire, Y Ben-David   +24 more
core   +2 more sources

Droplet Digital PCR versus qPCR for gene expression analysis with low abundant targets: from variable nonsense to publication quality data

Scientific Reports, 2017
Quantitative PCR (qPCR) has become the gold standard technique to measure cDNA and gDNA levels but the resulting data can be highly variable, artifactual and non-reproducible without appropriate verification and validation of both samples and primers ...
Sean C. Taylor, Genevieve Laperriere, H. Germain   +2 more
semanticscholar   +1 more source

The solution supramolecular structure of α2 → 8 polysialic acid suggests a structural cause for its low immunogenicity

FEBS Letters, EarlyView.
α2 → 8 polysialic acid elicits poor immunogenicity. Small‐angle scattering shows a supramolecular structure with parallel‐chain binding, although in different forms at μm and mm calcium. The major histocompatibility complex requires molecular weights around 2000 Da to produce antibodies, and 2000 Da polysialic oligomers will bind in these structures ...
Kenneth A. Rubinson
wiley   +1 more source

Static Analysis for Regular Expression Denial-of-Service Attacks [PDF]

arXiv, 2013
Regular expressions are a concise yet expressive language for expressing patterns. For instance, in networked software, they are used for input validation and intrusion detection. Yet some widely deployed regular expression matchers based on backtracking are themselves vulnerable to denial-of-service attacks, since their runtime can be exponential for ...
arxiv  

Consensus clustering and functional interpretation of gene-expression data [PDF]

, 2004
Microarray analysis using clustering algorithms can suffer from lack of inter-method consistency in assigning related gene-expression profiles to clusters.
Kellam, P., Liu, X., Martin, Nigel, Orengo, C.A., Swift, S., Tucker, A., Vinciotti, V.   +6 more
core   +2 more sources

UMI-count modeling and differential expression analysis for single-cell RNA sequencing

Genome Biology, 2018
Read counting and unique molecular identifier (UMI) counting are the principal gene expression quantification schemes used in single-cell RNA-sequencing (scRNA-seq) analysis.
Wenan Chen, Yan Li, J. Easton, D. Finkelstein, Gang Wu, Xiang Chen   +5 more
semanticscholar   +1 more source

Refining the NaV1.7 pharmacophore of a class of venom‐derived peptide inhibitors via a combination of in silico screening and rational engineering

FEBS Letters, EarlyView.
Venom peptides have shown promise in treating pain. Our study uses computer screening to identify a peptide that targets a sodium channel (NaV1.7) linked to chronic pain. We produced the peptide in the laboratory and refined its design, advancing the search for innovative pain therapies.
Gagan Sharma, Jennifer R. Deuis, Xinying Jia, Theo Crawford, Sassan Rahnama, Eivind A. B. Undheim, Irina Vetter, Yanni K. ‐Y. Chin, Mehdi Mobli   +8 more
wiley   +1 more source

MAGI2 Gene Region and Celiac Disease

Frontiers in Nutrition, 2019
Celiac disease (CD) patients present a loss of intestinal barrier function due to structural alterations in the tight junction (TJ) network, the most apical unions between epithelial cells.
Amaia Jauregi-Miguel, Izortze Santin, Izortze Santin, Koldo Garcia-Etxebarria, Ane Olazagoitia-Garmendia, Irati Romero-Garmendia, Maialen Sebastian-delaCruz, Iñaki Irastorza, Spanish Consortium for the Genetics of Celiac Disease, Ainara Castellanos-Rubio, Ainara Castellanos-Rubio, Jose Ramón Bilbao, Jose Ramón Bilbao   +12 more
doaj   +1 more source

An RNA-Seq Protocol for Differential Expression Analysis.

Cold Spring Harbor Protocols, 2019
Here we consider RNA-Seq, used to measure global gene expression through RNA fragmentation, capture, sequencing, and subsequent computational analysis.
Nick D. L. Owens, Elena De Domenico, M. Gilchrist   +2 more
semanticscholar   +1 more source