Results 71 to 80 of about 8,341,413 (332)

Prognostic Impact of Treatment Modalities, Including Targeted Compartmental Radio‐Immunotherapy, in a Cohort of Neuroblastoma Patients With CNS Metastases at Relapse

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Introduction Neuroblastoma (NB) with central nervous system (CNS) metastases is rare at diagnosis, but occurs more often during relapse/progression. Patients with CNS metastases face a dismal prognosis, with no standardized curative treatment available.
Vicente Santa‐Maria Lopez, Anna Felip‐Badia, Marina Caballero‐Bellon, Nazaret Sanchez‐Sierra, Alicia Castañeda, Moira Garraus, Maite Gorostegui, Margarida Simão‐Rafael, Juan Pablo Muñoz, Marta Perez‐Somarriba, Salvador Mañe, Mariana Cecilia Planells, Sara Perez‐Jaume, Jaume Mora   +13 more
wiley   +1 more source

Genome-Wide Identification, Characterization and Expression Profile of F-Box Protein Family Genes Shed Light on Lateral Branch Development in Cultivated Peanut (Arachis hypogaea L.)

Horticulturae
F-box proteins are a large gene family in plants, and play crucial roles in plant growth, development, and stress response. To date, a comprehensive investigation of F-box family genes in peanuts, and their expression pattern in lateral branch ...
Chuheng Li, Liguo Guo, Weiqian Wang, Penghui Miao, Guojun Mu, Charles Y. Chen, Chengsheng Meng, Xinlei Yang   +7 more
doaj   +1 more source

Pathogenic Germline PALB2 and RAD50 Variants in Patients With Relapsed Ewing Sarcoma

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Approximately 10% of patients with Ewing sarcoma (EwS) have pathogenic germline variants. Here, we report two cases: first, a novel germline pathogenic variant in partner and localizer of BRCA2 (PALB2) in a patient with a late EwS relapse. Its impact on homologous recombination is demonstrated, and breast cancer risk is discussed.
Molly Mack, A. Carolina Tufino, Mohd Azrin Jamalruddin, Sreya Dey, Yinghong Pan, Elina Mukherjee, Jessica D. Daley, Julia Meade, Mahmoud Aarabi, Lisa Maurer, James Cooper, Kara A. Bernstein, Kelly M. Bailey   +12 more
wiley   +1 more source

Identification of the PLATZ Gene Family in Peanut and Its Expression Analysis under Salt Stress and Drought Stress

Guangdong nongye kexue
【Objective】Plant AT-rich sequence and zinc-binding (PLATZ) transcription factors are plant-specific, zinc-dependent DNA-binding proteins that play a role in regulating plant growth and environmental stress responses. To clarify the characteristics of the
Xinqi CHEN, Xiongjian LIN, Mengqin HU, Binquan TANG, Xiaoli WU, Jiazhuang TAN, Shaochai CHEN, Changyi SONG, Jiaxing LI, Enyou FENG   +9 more
doaj   +1 more source

Deep generative modeling for single-cell transcriptomics. [PDF]

, 2018
Single-cell transcriptome measurements can reveal unexplored biological diversity, but they suffer from technical noise and bias that must be modeled to account for the resulting uncertainty in downstream analyses.
A Regev, A Tanay, A Wagner, A Zeisel, AP Patel, B Wang, BK Tusi, CA Vallejos, CA Vallejos, D DeTomaso, D Grün, D Risso, DM Blei, E Pierson, FA Wolf, G Finak, G Görgün, GXY Zheng, HI Nakaya, J Ding, J Fan, Jeffrey Regier, JT Gaublomme, K Shekhar, L Haghverdi, L Held, M Stoeckius, MD Robinson, MI Love, Michael B. Cole, Michael I. Jordan, Nir Yosef, PV Kharchenko, Q Li, RE Kass, Romain Lopez, S Prabhakaran, S Semrau, U Shaham, WE Johnson   +39 more
core   +1 more source

Improved Outcomes for Older Children, Adolescents, and Young Adults With Neuroblastoma in the Post‐Immunotherapy Era: An Updated Report From the International Neuroblastoma Risk Group

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background We describe clinical and biologic characteristics of neuroblastoma in older children, adolescents, and young adults (OCAYA); describe survival outcomes in the post‐immunotherapy era; and identify if there is an age cut‐off that best discriminates outcomes.
Rebecca J. Deyell, Kavitha Srivatsa, Paola Angelini, Pei‐Chi Kao, Brady Payne, Arlene Naranjo, Sveva Castelli, Miho Kato, Miki Ohira, Ulriche Pöetschger, Yaël Mossé, Lucas Moreno, Meredith S. Irwin, Ramya Ramanujachar, Wendy B. London   +14 more
wiley   +1 more source

Expression Data Analysis with Reactome [PDF]

Current Protocols in Bioinformatics, 2015
AbstractThe Reactome database of curated biological pathways provides a tool for visualizing user‐supplied expression data as an overlay on pathway diagrams, thereby affording an effective means to examine expression of the constituents of the pathway and determine whether all that are necessary are present.
Steve, Jupe, Antonio, Fabregat, Henning, Hermjakob   +2 more
openaire   +2 more sources

Psychological Safety Among Interprofessional Pediatric Oncology Teams in Germany: A Nationwide Survey

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Psychological safety (PS) is essential for teamwork, communication, and patient safety in complex healthcare environments. In pediatric oncology, interprofessional collaboration occurs under high emotional and organizational demands. Low PS may increase stress, burnout, and adverse events.
Alexandros Rahn, Anna‐Lena Herbach, Christian Bock, Katharina Fleig, Urs Mücke   +4 more
wiley   +1 more source

Characterization, Expression Profile Analysis, and Functional Prediction of UGP Gene Family in Dendrocalamus brandisii

Plants
UDP-glucose pyrophosphorylase (UGPase) is essential for carbohydrate metabolism, catalyzing UDP-glucose synthesis, a precursor for sucrose and cellulose biosynthesis.
He Li, Chongyang Wu, Xiangyi Li, Junlei Xu, Zhanchao Cheng, Jian Gao   +5 more
doaj   +1 more source

In Silico Genome-Wide Analysis of the Pear (Pyrus bretschneideri) KNOX Family and the Functional Characterization of PbKNOX1, an Arabidopsis BREVIPEDICELLUS Orthologue Gene, Involved in Cell Wall and Lignin Biosynthesis

Frontiers in Genetics, 2019
Stone cells are a characteristic trait of pear fruit, but the contents and sizes of stone cells negatively correlate with fruit texture and flavor.
Xi Cheng, Manli Li, Muhammad Abdullah, Guohui Li, Jingyun Zhang, Jingyun Zhang, Muhammad Aamir Manzoor, Han Wang, Qing Jin, Taoshan Jiang, Yongping Cai, Dahui Li, Yi Lin   +12 more
doaj   +1 more source