Results 91 to 100 of about 31,723,480 (301)
Fuzzy Clustering Models for Gene Expression Data Analysis [PDF]
With the advent of microarray technology, it is possible to monitor gene expression of tens of thousands of genes in parallel. In order to gain useful biological knowledge, it is necessary to study the data and identify the underlying patterns, which ...
Wang, Yu
core
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
, 2020 Raw data from experiments in article "Data describing expression of formyl peptide receptor 2 in human articular chondrocytes".THIS DATASET IS ARCHIVED AT DANS/EASY, BUT NOT ACCESSIBLE HERE.
Önnheim, K (via Mendeley Data) +1 more
core +1 more source
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
Endogenous fluorescent reporters for heat shock proteins are not detectable after stress induction
microPublication BiologyMitochondria and the endoplasmic reticulum (ER) utilise unique unfolded protein response (UPR) mechanisms to maintain cellular proteostasis. Heat shock proteins (HSPs) are UPR chaperones induced by specific stressors to promote protein folding.
Priya Thirumaran +2 more
doaj +1 more source
Discovering transcriptional modules by Bayesian data integration [PDF]
, 2010 Motivation: We present a method for directly inferring transcriptional modules (TMs) by integrating gene expression and transcription factor binding (ChIP-chip) data.
Richard S. Savage +15 more
core +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
microPublication BiologyIGT/LAZY proteins play a central role in determining gravitropic set point angle and orientation of lateral organs across plant species. Recent work in model systems has demonstrated that interactions between IGT/LAZY proteins and BREVIS RADIX (BRX ...
Jessica M. Waite +4 more
doaj +1 more source
, 2020 This dataset contains key characteristics about the data described in the Data Descriptor High-throughput identification of protein functional similarities using a gene-expression-based siRNA screen.
Scientific Data Curation Team (7929692)
core +1 more source