Results 101 to 110 of about 31,723,480 (301)

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

LIVEtools: an R Package for Visualizing C. elegans Embryo Cell Tracking Data

microPublication Biology
Automated cell tracking in the C. elegans embryo using the StarryNite software pipeline has been a powerful tool to quantify the embryonic lineage, to define the spatiotemporal dynamics of gene expression, and to characterize developmental defects in ...
Yuntian Gan, Sreekar Kutagulla, John Isaac Murray, Priya Sivaramakrishnan   +3 more
doaj   +1 more source

Data for: Gene Expression Profiling of Bronchoalveolar Lavage Cells Associates with Lung Allograft Acute Rejection

, 2021
The final pheno data file is a per sample table of clinical characteristics. The log2count data file is a per sample table of gene expression values.THIS DATASET IS ARCHIVED AT DANS/EASY, BUT NOT ACCESSIBLE HERE.
Weigt, S (via Mendeley Data), Weigt, Stephen   +1 more
core   +1 more source

Haploidentical Hematopoietic Cell Transplantation for Infants With X‐Linked Severe Combined Immunodeficiency Using Post‐Transplant Cyclophosphamide

Pediatric Blood &Cancer, EarlyView.
Shuhei Takahashi, Akito Kawachi, Dan Tomomasa, Eri Watanabe, Yuji Fujita, Yuya Sato, Masahiro Sekiguchi, Kentaro Watanabe, Moe Hidaka, Akihiro Hoshino, Takahiro Kamiya, Masatoshi Takagi, Hirokazu Kanegane, Motohiro Kato   +13 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Tau Regulates Endoreplication in Drosophila Malpighian Tubules

microPublication Biology
Endoreplication drives polyploidy in metabolically active epithelial tissues. Here we show that loss of Drosophila Tau increases nuclear size and DAPI fluorescence in principal and stellate cells of the Malpighian tubule, indicative of elevated DNA ...
Neha Tiwari, Madhu Tapadia
doaj   +1 more source

A cDNA Microarray Gene Expression Data Classifier for Clinical Diagnostics Based on Graph Theory [PDF]

, 2011
Despite great advances in discovering cancer molecular profiles, the proper application of microarray technology to routine clinical diagnostics is still a challenge. Current practices in the classification of microarrays' data show two main limitations:
Stefano Di Carlo, Politano, Gianfranco Michele Maria, Benso, Alfredo, Gianfranco Politano, Di Carlo, Stefano, Alfredo Benso   +5 more
core   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Exploring Proteomic Differences in PBMCs for Sex-Specific Insights into Alzheimer's Disease

microPublication Biology
Peripheral blood mononuclear cells (PBMCs) offer a minimally invasive window into systemic biology and immune dysregulation in Alzheimer’s disease (AD). We performed quantitative proteomic profiling of PBMCs from male and female AD patients and controls ...
Takako Ishida-Takaku, Colin Combs
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source