Results 121 to 130 of about 31,723,480 (301)

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Perception of Enterococcus faecalis without infection induces fmo-2 in C. elegans

microPublication Biology
C. elegans pathogenic susceptibility is influenced by the worm’s detection of its environment and its capacity to resist and resolve damage following infection.
Megan L Schaller, Madeline M Sykes, Sarah A Easow, Faith R Carranza, Angela M Tuckowski, Yatrik M Shah, Scott F Leiser   +6 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

The specificity of CTBP dehydrogenase inhibitors MTOB and 4-Cl-HIPP

microPublication Biology
C-terminal binding proteins (CTBPs) are conserved transcriptional repressors important in cancer and inflammation. Uniquely amongst transcriptional co-regulators, CTBPs possess a functional dehydrogenase domain.
Benjamin A. Stickland, Franziska Greulich, Nina Henriette Uhlenhaut   +2 more
doaj   +1 more source

Data of gene expression detection and enzyme activity analysis

Data of gene expression detection and enzyme activity analysis.THIS DATASET IS ARCHIVED AT DANS/EASY, BUT NOT ACCESSIBLE HERE.
Zhang, Y (via Mendeley Data), Zhang, Yi
core   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Investigating the Effects of Arabidopsis thaliana Cruciferin Double Knockouts on Amino Acid Profiles, Dry Seed Proteome, and Oxidative Stress Levels

microPublication Biology
As plant seeds mature, they accumulate large quantities of seed storage proteins, which are a vital source of carbon, nitrogen, and sulfur necessary for establishing the seedling, especially during the transition from the heterotrophic to the ...
Clement Bagaza, Huda Ansaf, Abou Yobi, Ruthie Angelovici   +3 more
doaj   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Peach (Prunus persica) TAC1 protein interaction with a LIGHT HARVESTING CHLOROPHYLL A/B BINDING (LHCB) homolog and transcriptomic analyses reveal connections to photosynthesis

microPublication Biology
Plants receive and interpret external light, gravity, and temperature cues to both set and change the angles of their lateral organs for optimal growth and development.
Jessica M. Waite, Erik Burchard, Chris Dardick, Courtney A. Hollender   +3 more
doaj   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source