Results 51 to 60 of about 135,054 (291)

Using Gene Expression to Annotate Cardiovascular GWAS Loci

Frontiers in Cardiovascular Medicine, 2018
Genetic variants at hundreds of loci associated with cardiovascular phenotypes have been identified by genome wide association studies. Most of these variants are located in intronic or intergenic regions rendering the functional and mechanistic follow ...
Matthias Heinig, Matthias Heinig
doaj   +1 more source

Genome-wide identification of expression quantitative trait loci (eQTLs) in human heart. [PDF]

PLoS ONE, 2014
In recent years genome-wide association studies (GWAS) have uncovered numerous chromosomal loci associated with various electrocardiographic traits and cardiac arrhythmia predisposition.
Tamara T Koopmann, Michiel E Adriaens, Perry D Moerland, Roos F Marsman, Margriet L Westerveld, Sean Lal, Taifang Zhang, Christine Q Simmons, Istvan Baczko, Cristobal dos Remedios, Nanette H Bishopric, Andras Varro, Alfred L George, Elisabeth M Lodder, Connie R Bezzina   +14 more
doaj   +1 more source

Development of a Next-Generation NIL Library in Arabidopsis Thaliana for Dissecting Complex Traits [PDF]

, 2013
The identification of the loci and specific alleles underlying variation in quantitative traits is an important goal for evolutionary biologists and breeders.
Bauerle, William L., Fletcher, Richard S., Juenger, Thomas E., McKay, John K., Meyer, Eli, Mullen, Jack L., Reuning, Gretchen, Sen, Saunak, Yoder, Seth   +8 more
core   +3 more sources

Balanced Expression of the Diiron Oxygenase BioE Is Essential for Biotin Homeostasis in Elizabethkingia meningoseptica

Advanced Science, EarlyView.
BioE is a new diiron oxygenase that catalyzes the conversion of long‐chain acyl groups into pimeloyl thioester, initiating biotin synthesis. The overexpression of EmBioE disrupts lipid metabolic homeostasis, requiring repressor BioL to maintain a balance between long‐chain fatty acids and biotin synthesis.
Meng Zhang, Ying‐ying Fu, Xiaoqiang Yang, Qiuying Qin, Xinyu Su, Jiaming Fang, Yanhua Kang, Qingwen He, Zhi Ruan, Yongchang Xu   +9 more
wiley   +1 more source

Genomic regions associated with common root rot resistance in the barley variety Delta [PDF]

, 2010
Common root rot (CRR) caused by Bipolaris sorokiniana is a serious disease constraint in the dry temperate cereal growing regions of the world. Currently little is known about the genetic control of resistance to CRR in cereals.
Bovill, J., Lehmensiek, A., McNamara, R. B., Sutherland, M. W.   +3 more
core   +2 more sources

Temporal Transcriptional Regulation of Human Neuronal Differentiation via Forward Programming

Advanced Science, EarlyView.
Single‐cell profiling of TF‐induced forward programming versus stepwise dual‐SMAD differentiation reveals that divergent trajectories set the pace of neurogenesis. OLIG TFs advance cell‐cycle exit via NOTCH modulation, while NEUROD2 later accelerates maturation. The study elucidates transcriptional mechanisms governing differentiation timing, providing
Lingling Zhu, Weiguang Wang, Jian Zhang, Lei Liu, Minpeng Huang, Lei Diao, Shuang Feng, Qiong Yang, Hao Qiu, Bing Pan, Renee A Reijo Pera, Ji Liu, Ninuo Xia, Fang Fang   +13 more
wiley   +1 more source

Druggable genome-wide Mendelian randomization integrating GWAS and eQTL/pQTL data identifies targets for lung squamous cell carcinoma

Scientific Reports
Lung squamous cell carcinoma (LUSC) is one of the most common types of non-small cell lung cancer with poor prognosis. Druggable genome-wide Mendelian randomization (MR) was conducted to discover LUSC-related targets using expression quantitative trait ...
Shizhao Cheng, Hao Zhang, Zhenliang Shi, Daqiang Sun   +3 more
doaj   +1 more source

Allelic Variation in Maize Malate Dehydrogenase 7 Shapes Promoter Methylation and Banded Leaf and Sheath Blight Resistance

Advanced Science, EarlyView.
In this study maize chloroplastic malate dehydrogenase7 (ZmMDH7), is identified as a Rhizoctonia solani resistance gene in maize. ZmMDH7 is regulated by transcription factor ZmWRKY44 via pathogens challenge to elevate mitochondrial ROS and SA signaling pathway.
Luyang Wei, Junbin Chen, Chuang Liu, DanDan Liu, Meida Du, Shengfeng He, Wenyu Cheng, Vijai Bhadauria, You‐Liang Peng, Wangsheng Zhu   +9 more
wiley   +1 more source

The evolution of genetic architectures underlying quantitative traits

, 2013
In the classic view introduced by R. A. Fisher, a quantitative trait is encoded by many loci with small, additive effects. Recent advances in QTL mapping have begun to elucidate the genetic architectures underlying vast numbers of phenotypes across ...
Plotkin, Joshua B., Rajon, Etienne
core   +1 more source

Pleiotropy of FRIGIDA enhances the potential for multivariate adaptation. [PDF]

, 2013
An evolutionary response to selection requires genetic variation; however, even if it exists, then the genetic details of the variation can constrain adaptation.
Easlon, Hsien M, Juenger, Thomas E, Lasky, Jesse R, Lovell, John T, McKay, John K, Michaels, Scott D, Platt, Alexander, Richards, James H, Sen, Saunak, Yu, Xuhong   +9 more
core   +1 more source