Results 71 to 80 of about 3,145 (159)

Targeting transglutaminase 2 mediated exostosin glycosyltransferase 1 signaling in liver cancer stem cells with acyclic retinoid

Cell Death and Disease, 2023
Transglutaminase 2 (TG2) is a multifunctional protein that promotes or suppresses tumorigenesis, depending on intracellular location and conformational structure.
Xian-Yang Qin, Yutaka Furutani, Kento Yonezawa, Nobutaka Shimizu, Miyuki Kato-Murayama, Mikako Shirouzu, Yali Xu, Yumiko Yamano, Akimori Wada, Luc Gailhouste, Rajan Shrestha, Masataka Takahashi, Jeffrey W. Keillor, Ting Su, Wenkui Yu, Shinya Fujii, Hiroyuki Kagechika, Naoshi Dohmae, Yohei Shirakami, Masahito Shimizu, Takahiro Masaki, Tomokazu Matsuura, Harukazu Suzuki, Soichi Kojima   +23 more
doaj   +1 more source

STC1‐Based Activation of NF‐κB Signaling Pathway Induces Epthithelial–Mesenchymal Transition Thus Promotes Progression and Temozolomide Resistance of Glioblastoma

The FASEB Journal, Volume 39, Issue 19, 15 October 2025.
Glioblastoma (GBM), a neuroepithelial‐derived lethal malignancy, remains incurable due to its intrinsic heterogeneity, necessitating molecular biomarkers for precision therapeutics. STC1 promotes GBM progression and temozolomide (TMZ) resistance by activating the NF‐κB signaling pathway, which drives epithelial–mesenchymal transition (EMT) and enhances
Jia Wang, Beichen Zhang, Haoyu Zhou, Bin Liu, Xiaobin Bai, Wei Wu, Ruichun Li, Wanfu Xie   +7 more
wiley   +1 more source

The EXT1/EXT2 tumor suppressors: catalytic activities and role in heparan sulfate biosynthesis [PDF]

EMBO reports, 2000
The D‐glucuronyltransferase and N‐acetyl‐D‐glucosaminyltransferase reactions in heparan sulfate biosynthesis have been associated with two genes, EXT1 and EXT2, which are also implicated in the inherited bone disorder, multiple exostoses. Since the cell systems used to express recombinant EXT proteins synthesize endogenous heparan sulfate, and the EXT ...
C, Senay, T, Lind, K, Muguruma, Y, Tone, H, Kitagawa, K, Sugahara, K, Lidholt, U, Lindahl, M, Kusche-Gullberg   +8 more
openaire   +2 more sources

Heterogeneity of Extracellular Vesicles and Non‐Vesicular Nanoparticles in Glioblastoma

Journal of Extracellular Vesicles, Volume 14, Issue 10, October 2025.
ABSTRACT It is increasingly clear that intercellular communication is largely mediated by lipid‐bilayer, membrane‐bound extracellular vesicles (EVs) and amembranous, non‐vesicular extracellular particles (NVEPs), including exomeres and the recently identified supermeres.
Tuoye Xu, Joao A. Paulo, Piyan Zhang, Xinyue Liu, Alya Nguyen, Yuanhua Cheng, Clark Massick, Yanhong Zhang, Dennis K. Jeppesen, Qin Zhang, James N. Higginbotham, Oleg S. Tutanov, Anna M. Krichevsky, Daniel T. Chiu, Steve P. Gygi, Kasey C. Vickers, Jeffrey L. Franklin, Robert J. Coffey, Al Charest   +18 more
wiley   +1 more source

Hsa_Circ_0008035 drives immune evasion of gastric cancer via promoting EXT1-mediated nuclear translocation of PKM2

Translational Oncology
Circular RNAs (circRNAs) have been reported to be associated with the malignant phenotypes of cancer. However, the role and underlying mechanism of hsa_Circ_0008035 in colorectal cancer (CRC) remains unclear. In this study, we elucidated the pivotal role
Rongqi Jiang, Ping Li, Enqing Meng, Xu Cheng, Xinyi Wu, Hao Wu   +5 more
doaj   +1 more source

The Pathophysiological Functions of Heparanases: From Evolution, Structural and Tissue‐Specific Perspectives

The FASEB Journal, Volume 39, Issue 17, 15 September 2025.
Heparanase 1 (HPSE1) and Heparanase 2 (HPSE2) exhibit opposing expression patterns and functions in pathological contexts, such as cancer. Here, we describe their specific expression in immune cells and their implications in skin diseases. Although they are structurally similar and considered to be ‘cousins’, we found no common ancestor and that HPSE2 ...
Elham Vahdatahar, Clément Daviaud, Hugo Main, Rachel Havret, Claire Debarnot, Laure Favot‐Laforge, Jean‐François Jégou, Ingrid Fruitier‐Arnaudin, Antoine Dufour, Romain Vivès, Franck Morel, Yves Bourne, Kévin Baranger   +12 more
wiley   +1 more source

Novel EXT1 variants cause divergent symptom severity in multiple cartilaginous exostoses: a family report

Egyptian Journal of Medical Human Genetics
Background Multiple cartilaginous exostoses (MCE) are a rare genetic disorder characterized by multiple osteochondromas in the metaphysis of long bones. Case Presentation.
Gozde Atasever Yildirim, Ozlem Anlas, Rabia Miray Kisla Ekinci   +2 more
doaj   +1 more source

Maximizing Efficacy of Cancer Nanovaccines and Immune Cells Landscape in Responders and Non‐Responders to Immunotherapy

Advanced Science, Volume 12, Issue 35, September 18, 2025.
To maximize the efficacy of cancer vaccines, adjuvants, collection, lysis, purification, oxidation, loading sites, and sizes, etc., are investigated. The optimized cancer nanovaccines loading whole tumor antigens can cure all or most tumor‐bearing mice in multiple mouse cancer models.
Xiangxiang Xu, Lu Diao, Jin Wang, Ao Zhu, Xianlan Chen, Yan Zheng, Yuhan Liu, Kang Hu, Jiashan Zhu, Cheng Ding, Chang Li, Yunzhi Pan, Jun Zhao, Mi Liu   +13 more
wiley   +1 more source

Protective mechanisms against Alzheimer's disease in APOE3‐Christchurch homozygous astrocytes

Alzheimer's &Dementia, Volume 21, Issue 9, September 2025.
Abstract INTRODUCTION Alzheimer's disease (AD) is characterized by tau pathology, leading to neurodegeneration. Astrocytes regulate central nervous system homeostasis and influence AD progression. The APOE3‐Christchurch (APOE3‐Ch) variant is linked to AD resilience, but its protective mechanisms remain unclear.
Xinran Tian, Erica Keane Rivera, Inyoung Hwang, Arina A. Nikitina, Jennifer A. Smith, Youngsuh J. Cho, Julia Sala‐Jarque, Austin DuBose, Clare Andriola, Toby Gollan‐Myers, Kenneth S. Kosik   +10 more
wiley   +1 more source

Hereditary Multiple Exostoses: Clinical, Molecular and Radiologic Survey in 9 Families

Prague Medical Report, 2017
Hereditary multiple exostoses (HME) represents a heterogeneous group of diseases often associated with progressive skeletal deformities. Most frequently, mutations in EXT1 and EXT2 genes with autosomal dominant inheritance are responsible for HME. In our
Karel Medek, Jiří Zeman, Tomáš Honzík, Hana Hansíková, Štěpánka Švecová, Kamila Beránková, Vendula Kučerová Vidrová, Miloslav Kuklík, Jiří Chomiak, Markéta Tesařová   +9 more
doaj   +1 more source