Results 71 to 80 of about 4,149 (184)

EXT1 and NCAM1-associated membranous lupus nephritis in a cohort of patients undergoing repeat kidney biopsies [PDF]

, 2022
Paul Miller, Tiffany Caza, Christopher P. Larsen, Vivek Charu   +3 more
openalex   +1 more source

A broad spectrum of genomic changes in latinamerican patients with EXT1/EXT2-CDG [PDF]

Scientific Reports, 2014
Multiple osteochondromatosis (MO), or EXT1/EXT2-CDG, is an autosomal dominant O-linked glycosylation disorder characterized by the formation of multiple cartilage-capped tumors (osteochondromas). In contrast, solitary osteochondroma (SO) is a non-hereditary condition.
Delgado, M. A., Martinez-Domenech, G., Sarrión Pérez-Caballero, Patricia, Urreizti, Roser, Zecchini, L., Robledo, H. H., Segura, F., Dodelson de Kremer, Raquel, Balcells Comas, Susana, Grinberg Vaisman, Daniel Raúl, Asteggiano, Carla   +10 more
openaire   +6 more sources

STC1‐Based Activation of NF‐κB Signaling Pathway Induces Epthithelial–Mesenchymal Transition Thus Promotes Progression and Temozolomide Resistance of Glioblastoma

The FASEB Journal, Volume 39, Issue 19, 15 October 2025.
Glioblastoma (GBM), a neuroepithelial‐derived lethal malignancy, remains incurable due to its intrinsic heterogeneity, necessitating molecular biomarkers for precision therapeutics. STC1 promotes GBM progression and temozolomide (TMZ) resistance by activating the NF‐κB signaling pathway, which drives epithelial–mesenchymal transition (EMT) and enhances
Jia Wang, Beichen Zhang, Haoyu Zhou, Bin Liu, Xiaobin Bai, Wei Wu, Ruichun Li, Wanfu Xie   +7 more
wiley   +1 more source

Exploration of dilated cardiomyopathy for biomarkers and immune microenvironment: evidence from RNA-seq

BMC Cardiovascular Disorders, 2022
Background The pathogenic mechanism of dilated cardiomyopathy (DCM) remains to be defined. This study aimed to identify hub genes and immune cells that could serve as potential therapeutic targets for DCM.
Chenggang Fang, Zhan Lv, Zhimin Yu, Kexin Wang, Chengkai Xu, Yixuan Li, Yanggan Wang   +6 more
doaj   +1 more source

Heterogeneity of Extracellular Vesicles and Non‐Vesicular Nanoparticles in Glioblastoma

Journal of Extracellular Vesicles, Volume 14, Issue 10, October 2025.
ABSTRACT It is increasingly clear that intercellular communication is largely mediated by lipid‐bilayer, membrane‐bound extracellular vesicles (EVs) and amembranous, non‐vesicular extracellular particles (NVEPs), including exomeres and the recently identified supermeres.
Tuoye Xu, Joao A. Paulo, Piyan Zhang, Xinyue Liu, Alya Nguyen, Yuanhua Cheng, Clark Massick, Yanhong Zhang, Dennis K. Jeppesen, Qin Zhang, James N. Higginbotham, Oleg S. Tutanov, Anna M. Krichevsky, Daniel T. Chiu, Steve P. Gygi, Kasey C. Vickers, Jeffrey L. Franklin, Robert J. Coffey, Al Charest   +18 more
wiley   +1 more source

The Pathophysiological Functions of Heparanases: From Evolution, Structural and Tissue‐Specific Perspectives

The FASEB Journal, Volume 39, Issue 17, 15 September 2025.
Heparanase 1 (HPSE1) and Heparanase 2 (HPSE2) exhibit opposing expression patterns and functions in pathological contexts, such as cancer. Here, we describe their specific expression in immune cells and their implications in skin diseases. Although they are structurally similar and considered to be ‘cousins’, we found no common ancestor and that HPSE2 ...
Elham Vahdatahar, Clément Daviaud, Hugo Main, Rachel Havret, Claire Debarnot, Laure Favot‐Laforge, Jean‐François Jégou, Ingrid Fruitier‐Arnaudin, Antoine Dufour, Romain Vivès, Franck Morel, Yves Bourne, Kévin Baranger   +12 more
wiley   +1 more source

Targeting transglutaminase 2 mediated exostosin glycosyltransferase 1 signaling in liver cancer stem cells with acyclic retinoid

Cell Death and Disease, 2023
Transglutaminase 2 (TG2) is a multifunctional protein that promotes or suppresses tumorigenesis, depending on intracellular location and conformational structure.
Xian-Yang Qin, Yutaka Furutani, Kento Yonezawa, Nobutaka Shimizu, Miyuki Kato-Murayama, Mikako Shirouzu, Yali Xu, Yumiko Yamano, Akimori Wada, Luc Gailhouste, Rajan Shrestha, Masataka Takahashi, Jeffrey W. Keillor, Ting Su, Wenkui Yu, Shinya Fujii, Hiroyuki Kagechika, Naoshi Dohmae, Yohei Shirakami, Masahito Shimizu, Takahiro Masaki, Tomokazu Matsuura, Harukazu Suzuki, Soichi Kojima   +23 more
doaj   +1 more source

Maximizing Efficacy of Cancer Nanovaccines and Immune Cells Landscape in Responders and Non‐Responders to Immunotherapy

Advanced Science, Volume 12, Issue 35, September 18, 2025.
To maximize the efficacy of cancer vaccines, adjuvants, collection, lysis, purification, oxidation, loading sites, and sizes, etc., are investigated. The optimized cancer nanovaccines loading whole tumor antigens can cure all or most tumor‐bearing mice in multiple mouse cancer models.
Xiangxiang Xu, Lu Diao, Jin Wang, Ao Zhu, Xianlan Chen, Yan Zheng, Yuhan Liu, Kang Hu, Jiashan Zhu, Cheng Ding, Chang Li, Yunzhi Pan, Jun Zhao, Mi Liu   +13 more
wiley   +1 more source

Protective mechanisms against Alzheimer's disease in APOE3‐Christchurch homozygous astrocytes

Alzheimer's &Dementia, Volume 21, Issue 9, September 2025.
Abstract INTRODUCTION Alzheimer's disease (AD) is characterized by tau pathology, leading to neurodegeneration. Astrocytes regulate central nervous system homeostasis and influence AD progression. The APOE3‐Christchurch (APOE3‐Ch) variant is linked to AD resilience, but its protective mechanisms remain unclear.
Xinran Tian, Erica Keane Rivera, Inyoung Hwang, Arina A. Nikitina, Jennifer A. Smith, Youngsuh J. Cho, Julia Sala‐Jarque, Austin DuBose, Clare Andriola, Toby Gollan‐Myers, Kenneth S. Kosik   +10 more
wiley   +1 more source

Hereditary Multiple Exostoses: Current Insights

Orthopedic Research and Reviews, 2019
Antonio D’Arienzo, Lorenzo Andreani, Federico Sacchetti, Simone Colangeli, Rodolfo Capanna Department of Translational Research on New Surgical and Medical Technologies, University of Pisa, Pisa, ItalyCorrespondence: Federico SacchettiDepartment of
D'Arienzo A, Andreani L, Sacchetti F, Colangeli S, Capanna R   +4 more
doaj