Results 91 to 100 of about 1,653,621 (270)

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

A Multi-Center Time Study of Home Infusion Nurse Services During Therapy Initiation

Introduction Home infusion therapy is an established and growing model of care that allows patients to receive complex infusion treatments in the home setting.
Michelle Simpson, Danell Haines, Jennifer Charron   +2 more
core   +1 more source

New PK/PD profile improvement following cephalosporin extended infusion : a systematic review [PDF]

Antimicrobial resistance is a global problem that is currently experienced in various countries, both developed and developing countries. The lack of discovery of new antibiotics and the increasing incidence of Multidrug–Resistant Organisms (MDROs) have ...
Widyati, Widyati Widyati, Yasin, Nanang Munif, Nurani, Melisa Rizky   +2 more
core   +1 more source

Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research

FEBS Letters, EarlyView.
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley   +1 more source

Onboarding Home Infusion Anti-Infective Patients: A Descriptive Study of Nurse and Pharmacist Time

Introduction Home infusion anti-infective therapy is an important component of post-acute care, allowing patients to transition more quickly from facility-based treatment to home-based intravenous therapy.
Michelle Simpson, Danell Haines, Jennifer Charron   +2 more
core   +1 more source

Assessing the Extended In-Use Stability of the Infliximab Biosimilar PF-06438179/GP1111 Following Preparation for Intravenous Infusion

Drugs in R&D, 2019
Objective PF-06438179/GP1111 (PF-SZ-IFX) is an infliximab biosimilar. We evaluated the extended in-use physicochemical and biological stability of PF-SZ-IFX upon preparation for intravenous infusion. Methods Two batches of PF-SZ-IFX were reconstituted to
Maja Vimpolsek, Marie Gottar-Guillier, Emmanuel Rossy   +2 more
doaj   +1 more source

Safety of Extended Propofol Infusions in Critically Ill Pediatric Patients

Cureus
Introduction Propofol is a phenol agent with sedative and anesthetic properties that has been in use for decades, but with controversy in critically ill pediatric patients, given the concern for developing propofol-related infusion syndrome (PRIS). Our aim was to assess the risk of propofol infusions in the pediatric intensive care unit (PICU) at doses
Moas, Daniel, Aydin, Elber Y, Irazuzta, Jose, Filipp, Stephanie, Guthrie, Kourtney K, Manasco, Kalen, Pringle, Charlene   +6 more
openaire   +2 more sources

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Erratum: The OBTAINS study: A nationwide cross-sectional survey on the implementation of extended or continuous infusion of β-lactams and vancomycin among neonatal sepsis patients in China

Frontiers in Pharmacology, 2022
Frontiers Production Office
doaj   +1 more source

Effect of extended intravenous diclofenac infusions on brain tissue oxygenation in patients with acute brain injury

Intensive Care Medicine Experimental
Background Fever is associated with worse outcomes in patients with acute brain injury. Diclofenac, a non-steroidal anti-inflammatory drug, is commonly used as antipyretic therapy. As evidence emerged that short diclofenac infusions (
Julian Klug, David Cortier, Stefan Wolf, Emmanuel Carrera, Charles Cerf, Urs Pietsch   +5 more
doaj   +1 more source