Results 91 to 100 of about 38,609 (257)

Optimization of individualized faricimab dosing for patients with diabetic macular edema: Protocol for the SWAN open-label, single-arm clinical trial.

PLoS ONE
PurposeIn patients with diabetic macular edema (DME) from YOSEMITE/RHINE, dual angiopoietin-2/vascular endothelial growth factor-A (VEGF-A) inhibition with faricimab resulted in visual/anatomic improvements with extended dosing.
Takao Hirano, Toshinori Murata, Shintaro Nakao, Masahiko Shimura, Miho Nozaki, Kiyoshi Suzuma, Taiji Nagaoka, Masahiko Sugimoto, Yoshihiro Takamura, Tomoaki Murakami, Keisuke Iwasaki, Jun Tsujimura, Shigeo Yoshida   +12 more
doaj   +1 more source

“Extended” Antipsychotic Dosing in the Maintenance Treatment of Schizophrenia

, 2010
Objective: In the treatment of schizophrenia, all currently available oral antipsychotics are administered at least once daily, with strict adherence strongly encouraged to minimize risk of relapse.
Mann, Steve, Shammi, Chekkera, Alan Feingold, Gary Remington, Shitij Kapur, Philip Seeman, Feingold, Alan, Seeman, Philip, Steve Mann, Chekkera Shammi, Remington, Gary, Kapur, Shitij   +11 more
core   +1 more source

No difference in radiologic outcomes for natalizumab patients treated with extended interval dosing compared with standard interval dosing: Real-world evidence from MS PATHS

, 2022
BACKGROUND: Extended interval dosing (EID; average dosing interval approximately every 6 weeks) of natalizumab is associated with significantly lower risk of progressive multifocal leukoencephalopathy than standard interval dosing (SID; every 4 weeks) in
Williams, James R, Liao, Shirley, Ryerson, Lana Zhovtis, Campbell, Nolan, Charvet, Leigh E, Fisher, Elizabeth, Krupp, Lauren B, Naismith, Robert T, de Moor, Carl   +8 more
core   +1 more source

ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan, Yan Jiang, Yuxuan Yong, Tianshuo Zhang, Niannian Zhang, Qianqian Zeng, Xue Gong, Li Meng, Fangfang Bi, Yongmin Liu   +9 more
wiley   +1 more source

[18F]Fluorodeprenyl‐D2 PET as a Tool to Monitor Disease Activity in GAD65‐Ab Autoimmune Encephalitis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To evaluate [18F]fluorodeprenyl‐D2 ([18F]F‐DED) positron‐emission tomography (PET) imaging as a biomarker of disease activity in autoimmune encephalitis (AIE) associated with glutamic acid decarboxylase 65 (GAD65) antibodies. Methods [18F]F‐DED PET was performed in 25 GAD65‐AIE patients and 8 controls using dynamic (0–60 min) and ...
Julia S. Dorneich, Jonathan A. Gernert, Hanna Zimmermann, Lisa Tagnin, Marianthi Zeinaki, Laura Sanzo, Letizia Vogler, Elisabeth Kaufmann, Justina Dargvainiene, Frank Leypoldt, Gérard N. Bischof, Robert Perneczky, Boris‐Stephan Rauchmann, Simon Lindner, Günter U. Höglinger, Rudolf A. Werner, Martin Kerschensteiner, Tania Kümpfel, Matthias Brendel, Franziska S. Thaler   +19 more
wiley   +1 more source

Treatment Patterns and Characteristics of Patients with Hereditary Angioedema Treated with Lanadelumab: A US Retrospective Chart Review

Drugs - Real World Outcomes
Background and Objective Hereditary angioedema presents as recurrent, unpredictable, and often debilitating attacks of cutaneous/submucosal swelling.
Maureen Watt, Rose Chang, Louise Huafeng Yu, Louise Clear, Maral DerSarkissian   +4 more
doaj   +1 more source

Improved antibody breadth with an extended primary dose interval of COVID-19 vaccine is overcome by boosters

Frontiers in Immunology
IntroductionDuring rollout of mRNA-based COVID-19 vaccines, several jurisdictions extended the interval between the first and second doses to prioritize wider population access to limited vaccine supply.
Jessica I. Ahmed, Samantha J. Krosta, Mandy N. Reimer, Winnie Cheung, Christine Mesa, Carmen Lopez, Rayeil J. Chua, Farah Alsattari, Alyssia Robinson, Kathy Manguiat, Naima Jahan, Bernard Abrenica, Angela Harris, Karla Cachero, Rissa Fabia, Jonathan Walker, Myo Minn Oo, Derek Stein, Derek Stein, Hezhao Ji, Hezhao Ji, Ruey-Chyi Su, Ruey-Chyi Su, Paul J. McLaren, Paul J. McLaren, Lyle R. McKinnon, Lyle R. McKinnon, Lyle R. McKinnon, T Blake Ball, T Blake Ball, Heidi Wood, John Kim, Sandra A. Kiazyk, Sandra A. Kiazyk, Catherine M. Card, Catherine M. Card   +35 more
doaj   +1 more source

Ofatumumab in Myelin Oligodendrocyte Glycoprotein Antibody–Associated Disease: A Comparison With Rituximab

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To evaluate the efficacy and safety of ofatumumab in patients with myelin oligodendrocyte glycoprotein antibody–associated disease (MOGAD), and compare it with rituximab. Methods We conducted a single–center, observational study including 22 MOGAD patients treated with ofatumumab and 21 treated with rituximab.
Yuxin Fan, Lei Zhou, Jingzi ZhangBao, Hongmei Tan, Zhouzhou Wang, Chao Quan   +5 more
wiley   +1 more source

Extended-Interval Gentamicin Dosing in Achieving Therapeutic Concentrations in Malaysian Neonates

The Journal of Pediatric Pharmacology and Therapeutics, 2015
OBJECTIVE: To evaluate the usefulness of extended-interval gentamicin dosing practiced in neonatal intensive care unit (NICU) and special care nursery (SCN) of a Malaysian hospital. METHODS: Cross-sectional observational study with pharmacokinetic analysis of all patients aged ≤28 days who received gentamicin treatment in NICU/SCN ...
Yee Shan, Low, Sin Li, Tan, Angeline Sl, Wan   +2 more
openaire   +3 more sources

White Matter Hyperintensity Burden and Short‐Interval Change Associated With Sleep Apnoea in the UK Biobank

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background and Purpose White matter hyperintensities (WMH) are a core neuroimaging marker of cerebral small vessel disease (CSVD). Sleep apnoea (SA) is a recognized vascular risk factor, but its associations with regional WMH burden, short‐interval WMH change and cognitive performance in population‐based cohorts remain incompletely defined. We
Peng Cheng, Diego Z. Carvalho, Shahid Karim, Anwar Chahal, Virend K. Somers   +4 more
wiley   +1 more source