Results 121 to 130 of about 38,609 (257)

High response rate with extended dosing of cemiplimab in advanced cutaneous squamous cell carcinoma

Journal for ImmunoTherapy of Cancer
Background Cemiplimab (Libtayo®), a human monoclonal immunoglobulin G4 antibody to the programmed cell death-1 receptor, is approved for the treatment of patients with advanced cutaneous squamous cell carcinoma (CSCC), who are not candidates for curative
Dirk Schadendorf, Thomas K Eigentler, Israel Lowy, Apostolos Papachristos, Samantha Bowyer, Friedegund Meier, Brigitte Dreno, Danny Rischin, Michael R Migden, Annette M Lim, Chrysalyne D Schmults, Brett G M Hughes, Axel Hauschild, Brian Stein, Emmanuel Okoye, Jocelyn Booth, Matthew G Fury, Alexander Guminski, Sophie Dalac, Frank Seebach, Marie Beylot-Barry, Suk-Young Yoo, Nicole Basset-Séguin, Sabiha Trabelsi Messai, Victoria Casado Echarren, Anne J Paccaly, Jenny-Hoa Nguyen   +26 more
doaj   +1 more source

Use of a Molecular Signature Response Classifier to Inform Treatment Selection Improves Clinical Disease Activity Among Patients with Rheumatoid Arthritis Initiating a Biologic or Targeted Synthetic Disease‐Modifying Antirheumatic Drug

Arthritis Care &Research, EarlyView.
Objective We assessed the effectiveness of PrismRA to improve clinical outcomes among patients with rheumatoid arthritis (RA) initiating treatment with a biologic or targeted synthetic disease‐modifying antirheumatic drug (b/tsDMARD). Methods PrismRA incorporated 19 gene expression features and four clinical features to assess a patient's likelihood of
Fenglong Xie, Timothy Beukelman, Nicholas P. McCormick, Jeffrey R. Curtis   +3 more
wiley   +1 more source

A real-world study on the safety profile of extended-interval dosing of immune checkpoint inhibitors for melanoma: a single-center analysis in Japan. [PDF]

Front Med (Lausanne), 2023
Ito T, Kaku-Ito Y, Ohno F, Nakahara T.
europepmc   +1 more source

Risk of Retinopathy Associated with Long‐Term Use of Hydroxychloroquine in Patients with Rheumatic Diseases: A Systematic Review and Meta‐Analysis

Arthritis Care &Research, EarlyView.
Objective We aimed to estimate the prevalence and cumulative incidence of hydroxychloroquine retinopathy (HCQ‐R) and its risk factors among patients receiving long‐term HCQ with rheumatic diseases through a systematic review and meta‐analysis of observational studies that used spectral‐domain optical coherence tomography (SD‐OCT) for screening ...
Narsis Daftarian, Chloe Yue, Steve D Levasseur, Hui Xie, J. Antonio Avina‐Zubieta   +4 more
wiley   +1 more source

Clinical Significance of Therapeutic Drug Level Monitoring for Mycophenolate in Patients With Extrarenal Systemic Lupus Erythematosus—A Systematic Review and Meta‐Analysis

Arthritis Care &Research, EarlyView.
Objective Clinical response to mycophenolic acid (MPA) is highly heterogeneous; thus, therapeutic drug level monitoring (TDM) may help improve treatment efficacy. This systematic review and meta‐analysis examined therapeutic ranges for MPA levels associated with better outcomes and safety in patients with systemic lupus erythematosus (SLE ...
Zahraa Qamhieh, Dalia Sriwi, Callie Saric, Tripti Singh, Christie M. Bartels, Shivani Garg   +5 more
wiley   +1 more source

Optimization of hemophilia B treatment via population PK modeling of rIX-FP, including a 3-week regimen

Frontiers in Pediatrics
BackgroundRecombinant factor IX–albumin fusion protein (rIX-FP) enables extended-interval prophylaxis for hemophilia B. While higher trough levels with reduced dosing frequency have been shown vs.
Naoki Terasaka, William Mckeand
doaj   +1 more source

A National Survey of Antimicrobial Dosing Strategies at Pediatric Institutions

, 2014
Background: Ideal antimicrobial utilization includes dosing strategies that serve to optimize pharmacokinetic and pharmacodynamic properties, such as the use of extended-interval dosing of aminoglycosides and extended-infusion dosing of ß-lactam ...
Kaminsky, Bonnie, Hubbard, Jaclyn
core  

Assessing the Sensitivity and the Clinical Impact of the 2023 American College of Rheumatology/EULAR Classification Criteria in Obstetric Antiphospholid Syndrome: Findings From a Multicenter Italian Cohort With a Long‐Term Follow‐Up

Arthritis Care &Research, EarlyView.
Objective The aim of this study was to evaluate the sensitivity of the 2023 American College of Rheumatology (ACR)/EULAR classification criteria for antiphospholipid syndrome (APS) in a real‐world cohort of women diagnosed with primary obstetric APS (oAPS) and to assess their ability to identify patients at risk of future pregnancy complications ...
Francesca Ruffilli, Cecilia Nalli, Francesca Crisafulli, Carlo Garaffoni, Marcello Govoni, Giulia Voltarel, Alba C. Pozzi, Beatrice Maranini, Ettore Silvagni, Alessandra Bortoluzzi, Angela Tincani   +10 more
wiley   +1 more source

Contribution of Trough Concentration Data in the Evaluation of Multiple-Dose Pharmacokinetics for Drugs with Delayed Distributional Equilibrium and Long Half-Life

Drug Design, Development and Therapy, 2020
Suein Choi,1,2 Sangil Jeon,3 Dong-Seok Yim,1,2 Seunghoon Han1,2 1Pharmacometrics Institute for Practical Education and Training (PIPET), College of Medicine, The Catholic University of Korea, Seoul, Korea; 2Department of Pharmacology, College of Medicine,
Choi S, Jeon S, Yim DS, Han S
doaj  

Parameters for successful monthly extended dosing of darbepoetin-a in patients under going hemodialysis

, 2009
Aim: To document the feasibility and report the results of dosing darbepoetin-a at extended intervals up to once monthly (QM) in a large dialysis patient population.
Martin, P.-Y., Glück, Z., J. Trachsler, Gauthier, T., P.-Y. Martin, Trachsler, J, Wahl, C, C. Wahl, Dickenmann, M, Wüthrich, R P., Burnier, M., R.P. Wüthrich, M. Dickenmann, Martin, P Y, Wüthrich, R. P., Wahl, C., M. Burnier, Gauthier, T, Z. Glück, Wüthrich, R P, Trachsler, J., T. Gauthier, Glück, Z, Dickenmann, M., Martin, Pierre-Yves, Brünisholz, M., M. Brünisholz, Brunier, M, Brünisholz, M   +28 more
core   +1 more source