Results 41 to 50 of about 38,609 (257)

A Meta-Analysis of Extended-Interval Dosing Versus Multiple Daily Dosing of Aminoglycosides [PDF]

Clinical Infectious Diseases, 1997
We conducted a meta-analysis of 22 randomized, controlled trials in which extended-interval dosing of aminoglycosides was compared with multiple daily dosing. When we classified intermediate outcomes as successes, we found that patients receiving extended-interval dosing were at significantly reduced risk of clinical treatment failure (risk difference,
T C, Bailey, J R, Little, B, Littenberg, R M, Reichley, W C, Dunagan   +4 more
openaire   +2 more sources

Healthcare resource utilization and costs for extended interval dosing of natalizumab in multiple sclerosis

, 2022
Aims: Natalizumab is approved as an infusion every 4 weeks (standard-interval dosing [SID]) in relapsing-remitting multiple sclerosis (MS). Extended-interval dosing (EID) reduces risk of progressive multifocal leukoencephalopathy (PML) compared with SID,
Lanzillo, Roberta, Carotenuto, Antonio, Morra, Vincenzo Brescia, Affinito, Giuseppina, Palladino, Raffaele, Moccia, Marcello, Loperto, Ilaria, Santoni, Laura, Masera, Silvia, Triassi, Maria   +9 more
core   +1 more source

Effectiveness of lanreotide autogel 120 mg at extended dosing intervals for acromegaly [PDF]

Endocrine, 2020
Abstract Purpose Recent data indicate that extended dosing intervals (EDIs) with lanreotide autogel 120 mg are effective and well-received among patients with acromegaly who have achieved biochemical control with monthly injections of long-acting somatostatin analogues (SSAs).
Ignacio Bernabéu, Carmen Fajardo, Mónica Marazuela, Fernando Cordido, Eva María Venegas, Pedro de Pablos-Velasco, Gonzalo Piedrola Maroto, María Pilar Olvera, Isabel Pavón de Paz, Davide Carvalho, Carme Romero, Guillermo De la Cruz, Cristina Álvarez Escolá   +12 more
openaire   +9 more sources

Immunogenicity of Alternative Dosing Schedules for HPV Vaccines among Adolescent Girls and Young Women: A Systematic Review and Meta-Analysis

Vaccines, 2020
Alternative dosing schedules for licensed human papilloma virus (HPV) vaccines, particularly single dose and extended intervals between doses (>12 months), are being considered to address vaccine shortages and improve operational flexibility. We searched
Andrew M. Secor, Matthew Driver, Brenda Kharono, Dianna Hergott, Gui Liu, Ruanne V. Barnabas, Peter Dull, Stephen E. Hawes, Paul K. Drain   +8 more
doaj   +1 more source

Flexibility of oral cholera vaccine dosing-a randomized controlled trial measuring immune responses following alternative vaccination schedules in a cholera hyper-endemic zone. [PDF]

PLoS Neglected Tropical Diseases, 2015
BACKGROUND:A bivalent killed whole cell oral cholera vaccine has been found to be safe and efficacious for five years in the cholera endemic setting of Kolkata, India, when given in a two dose schedule, two weeks apart.
Suman Kanungo, Sachin N Desai, Ranjan Kumar Nandy, Mihir Kumar Bhattacharya, Deok Ryun Kim, Anuradha Sinha, Tanmay Mahapatra, Jae Seung Yang, Anna Lena Lopez, Byomkesh Manna, Barnali Bannerjee, Mohammad Ali, Mandeep Singh Dhingra, Ananga Mohan Chandra, John D Clemens, Dipika Sur, Thomas F Wierzba   +16 more
doaj   +1 more source

The immunogenicity of an extended dosing interval of BNT162b2 against SARS-CoV-2 Omicron variant among healthy school-aged children, a randomized controlled trial

International Journal of Infectious Diseases, 2023
Objectives: To evaluate the immunogenicity of an extended interval regimen of BNT162b2 among healthy school-age children. Methods: A randomized-control trial conducted among healthy Thai children aged 5-11 years.
Napaporn Chantasrisawad, Chonnamet Techasaensiri, Pope Kosalaraksa, Wanatpreeya Phongsamart, Auchara Tangsathapornpong, Peera Jaru-Ampornpan, Jiratchaya Sophonphan, Piyarat Suntarattiwong, Thanyawee Puthanakit   +8 more
doaj   +1 more source

Covid-19 vaccination: What’s the evidence for extending the dosing interval?

BMJ, 2021
On 30 December the four UK chief medical officers announced that the second doses of the covid vaccines should be given towards the end of 12 weeks rather than in the previously recommended 3-4 weeks.
Iacobucci, Gareth, Mahase, Elisabeth
openaire   +2 more sources

Time Toxicity in Wilms Tumor: Quantifying the Burden of Healthcare Interaction in the First Year After Diagnosis

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Wilms tumor (WT) treatment imposes a significant time burden on patients and their families. Time toxicity is a patient‐centered metric that quantifies the burden of healthcare interaction. We sought to define time toxicity in the first year after diagnosis of WT and hypothesized that it would increase as tumor stage and treatment ...
Caleb Q. Ashbrook, Veerain Gupta, Nicholas J. Clark, Vijay Rings, Lauren E. Corona, Douglass B. Clayton, Daniel J. Benedetti   +6 more
wiley   +1 more source

Time-dependent pharmacodynamics of amikacin on Mycobacterium abscessus growth and resistance emergence

Microbiology Spectrum
Mycobacterium abscessus pulmonary disease is increasing in prevalence globally, particularly for individuals with cystic fibrosis. These infections are challenging to treat due to a high rate of resistance.
Joy E. Gibson, Nishant Nandanwar, Michael N. Neely   +2 more
doaj   +1 more source

From injection therapies to natalizumab: views on the treatment of multiple sclerosis

Therapeutic Advances in Neurological Disorders, 2012
Discoveries of the mechanisms that underlie the pathogenesis of multiple sclerosis have been acquired at an impressive rate over the last few decades and, as a consequence, a growing number of treatments are becoming available for this disease.
Roberto Bomprezzi, Darin T. Okuda, Yazan J. Alderazi, Olaf Stüve, Elliot M. Frohman   +4 more
doaj   +1 more source