Results 51 to 60 of about 41,221 (142)

Improved antibody breadth with an extended primary dose interval of COVID-19 vaccine is overcome by boosters

Frontiers in Immunology
IntroductionDuring rollout of mRNA-based COVID-19 vaccines, several jurisdictions extended the interval between the first and second doses to prioritize wider population access to limited vaccine supply.
Jessica I. Ahmed, Samantha J. Krosta, Mandy N. Reimer, Winnie Cheung, Christine Mesa, Carmen Lopez, Rayeil J. Chua, Farah Alsattari, Alyssia Robinson, Kathy Manguiat, Naima Jahan, Bernard Abrenica, Angela Harris, Karla Cachero, Rissa Fabia, Jonathan Walker, Myo Minn Oo, Derek Stein, Derek Stein, Hezhao Ji, Hezhao Ji, Ruey-Chyi Su, Ruey-Chyi Su, Paul J. McLaren, Paul J. McLaren, Lyle R. McKinnon, Lyle R. McKinnon, Lyle R. McKinnon, T Blake Ball, T Blake Ball, Heidi Wood, John Kim, Sandra A. Kiazyk, Sandra A. Kiazyk, Catherine M. Card, Catherine M. Card   +35 more
doaj   +1 more source

Extended-Interval Gentamicin Dosing in Achieving Therapeutic Concentrations in Malaysian Neonates

The Journal of Pediatric Pharmacology and Therapeutics, 2015
OBJECTIVE: To evaluate the usefulness of extended-interval gentamicin dosing practiced in neonatal intensive care unit (NICU) and special care nursery (SCN) of a Malaysian hospital. METHODS: Cross-sectional observational study with pharmacokinetic analysis of all patients aged ≤28 days who received gentamicin treatment in NICU/SCN ...
Yee Shan, Low, Sin Li, Tan, Angeline Sl, Wan   +2 more
openaire   +3 more sources

Population pharmacokinetics and optimized dosing of piperacillin-tazobactam in hematological patients with febrile neutropenia

Antimicrobial Agents and Chemotherapy
Hematological patients with febrile neutropenia receiving piperacillin-tazobactam may experience pharmacokinetic alterations that compromise drug exposure.
Julia Laporte-Amargos, Marta Ulldemolins, María Patricia Hernández-Mitre, Jason A. Roberts, Raul Rigo-Bonnin, Francisco Carmona-Torre, Maria Huguet, Pedro Puerta-Alcalde, Montserrat Arnan, Jose Luis del Pozo, Anna Torrent, Carolina García-Vidal, Anna Sureda, Alba Bergas, Enric Sastre-Escolà, Jordi Carratalà, Carlota Gudiol   +16 more
doaj   +1 more source

Subcutaneous injections of penicillin (SCIP): Convenient and effective treatment for Māori, Pacific Peoples and their families in preventing rheumatic heart disease.

PLOS Global Public Health
Acute rheumatic fever (ARF) and rheumatic heart disease (RHD) remain significant health issues for Māori and Pacific communities in Aotearoa New Zealand (NZ).
Julie Cooper, Monleigh Muliaumasealii, Dhevindri Moodley, Jacqui Ulugia, Anneka Anderson, Julie Bennett   +5 more
doaj   +1 more source

Extension of Dupilumab Injection Intervals in Chronic Rhinosinusitis with Nasal Polyps: A Real-World Study

Pharmaceuticals
Background/Objectives: Dupilumab is an effective long-term treatment for chronic rhinosinusitis with nasal polyps (CRSwNP), but continuous biweekly (Q2W) treatment is associated with high costs, cumulative drug exposure, and treatment burden.
Michael Habenbacher, Ulrich Moser, Angelika Lang, Ahmed Abaira, Jakob Pock, Thomas Lampl, Alexandros Andrianakis   +6 more
doaj   +1 more source

Safety and efficacy of extended versus standard interval dosing of anti-CD20 therapy in multiple sclerosis – A meta-analysis

Multiple Sclerosis Journal - Experimental, Translational and Clinical
Background Anti-CD20 therapy is a highly effective multiple sclerosis (MS) disease-modifying therapy, but may be complicated by infections, which has led to the utilization of different extended interval dosing (EID) regimens.
Mahmoud Elkhooly, Rhea Jacob, Torge Rempe   +2 more
doaj   +1 more source

Clinical implications of natalizumab Fab-arm exchange in patients with multiple sclerosis

Frontiers in Immunology
Natalizumab, a monoclonal antibody used to treat multiple sclerosis, can undergo Fab-arm exchange (FAE) with endogenous IgG4, resulting in a monovalent form with reduced avidity and presumed lower potency than the parental bivalent form.
Liza M.Y. Gelissen, Stefan P.H. van den Berg, Alyssa A. Toorop, Martijn T. Wijburg, Emma C. Tallantyre, Emma C. Tallantyre, Ninotska I.L. Derksen, Floris C. Loeff, Joep Killestein, Theo Rispens, Theo Rispens, Theo Rispens, Zoé L.E. van Kempen, the NEXT-MS study group   +13 more
doaj   +1 more source

Six‐Month Benralizumab Maintenance for Relapsing Chronic Eosinophilic Pneumonia Guided by Eosinophil Kinetics

Respirology Case Reports
Idiopathic chronic eosinophilic pneumonia (ICEP) often relapses upon corticosteroid tapering. Biologics targeting interleukin‐5 (IL‐5) are effective, but optimal dosing intervals remain unclear. We report a case of relapsing ICEP in a patient in her 50s.
Toshiyuki Sumi, Taiki Ishigooka, Kazuya Takeda, Taeka Naraoka, Naoki Shijubou, Yuichi Yamada, Hirofumi Chiba   +6 more
doaj   +1 more source

SARS-CoV-2 vaccination strategies: Should the extended dosing interval strategy be implemented in future pandemics?

Travel Medicine and Infectious Disease, 2023
Sandra Valderrama-Beltrán, Juliana Cuervo-Rojas, Samuel Martinez-Vernaza, Carlos A. Alvarez-Moreno, Alfonso J. Rodriguez-Morales   +4 more
doaj   +1 more source

High response rate with extended dosing of cemiplimab in advanced cutaneous squamous cell carcinoma

Journal for ImmunoTherapy of Cancer
Background Cemiplimab (Libtayo®), a human monoclonal immunoglobulin G4 antibody to the programmed cell death-1 receptor, is approved for the treatment of patients with advanced cutaneous squamous cell carcinoma (CSCC), who are not candidates for curative
Dirk Schadendorf, Thomas K Eigentler, Israel Lowy, Apostolos Papachristos, Samantha Bowyer, Friedegund Meier, Brigitte Dreno, Danny Rischin, Michael R Migden, Annette M Lim, Chrysalyne D Schmults, Brett G M Hughes, Axel Hauschild, Brian Stein, Emmanuel Okoye, Jocelyn Booth, Matthew G Fury, Alexander Guminski, Sophie Dalac, Frank Seebach, Marie Beylot-Barry, Suk-Young Yoo, Nicole Basset-Séguin, Sabiha Trabelsi Messai, Victoria Casado Echarren, Anne J Paccaly, Jenny-Hoa Nguyen   +26 more
doaj   +1 more source