Results 21 to 30 of about 38,609 (257)

Evaluating the impact of extended dosing intervals on mRNA COVID-19 vaccine effectiveness in adolescents [PDF]

BMC Medicine
Background Extending the dosing interval of a primary series of mRNA COVID-19 vaccination has been employed to reduce myocarditis risk in adolescents, but previous evaluation of impact on vaccine effectiveness (VE) is limited to risk after second dose ...
Tim K. Tsang, Sheena G. Sullivan, Yu Meng, Francisco Tsz Tsun Lai, Min Fan, Xiaotong Huang, Yun Lin, Liping Peng, Chengyao Zhang, Bingyi Yang, Kylie E. C. Ainslie, Benjamin J. Cowling   +11 more
doaj   +2 more sources

Safety and clinical outcomes of pembrolizumab standard-interval dosing versus extended-interval dosing in patients with breast cancer. [PDF]

Oncologist
Abstract Introduction Extended-interval (EI) dosing of pembrolizumab (400 mg IV every 6 weeks) was approved across all solid tumors based on pharmacokinetic modeling and exposure-response analyses.
LeVee A, Kordic A, Ruel N, Mortimer J, Kang I, McArthur H, Lechner MG, Tsai K.   +7 more
europepmc   +3 more sources

Predictive performance of gentamicin dosing nomograms

Drug Design, Development and Therapy, 2014
Jieon Lee,1 Seonghae Yoon,1 Donghoon Shin,1 HyeKyung Han,1 Hyungmi An,1,2 Jongtae Lee,1 Kyoung Soo Lim,3 Kyung-Sang Yu,1 Howard Lee11Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Hospital, Seoul ...
Lee J, Yoon S, Shin D, Han H, An H, Lee J, Lim KS, Yu KS, Lee H   +8 more
doaj   +1 more source

Extended-Interval Dosing Strategy of Immune Checkpoint Inhibitors in Lung Cancer: Will it Outlast the COVID-19 Pandemic? [PDF]

Frontiers in Oncology, 2020
Patients with lung cancer are particularly vulnerable to complications from coronavirus disease-2019 (COVID-19). Recurrent hospital visits and hospital admission are potential risk factors for acquiring infection with its causative pathogen, severe acute
Kartik Sehgal, Kartik Sehgal, Daniel B. Costa, Deepa Rangachari   +3 more
doaj   +2 more sources

Extended interval dosing of natalizumab: More evidence in support. [PDF]

Neurotherapeutics
Toljan K, Conway DS.
europepmc   +3 more sources

Modeling the Efficacy of Natalizumab in Multiple Sclerosis Patients Who Switch From Every‐4‐Week Dosing to Extended‐Interval Dosing [PDF]

Journal of Clinical Pharmacology, 2021
Kumar Kandadi Muralidharan, Pei-Ran Ho
exaly   +2 more sources

Comparison of clinical safety between standard versus extended interval dosing of immune checkpoint inhibitors: a real-world retrospective cohort study [PDF]

ESMO Open, 2023
J Colard-Thomas, Alexandre Thibault Jacques Maria, Jean-Luc Faillie   +2 more
exaly   +2 more sources

Optimizing dosing frequencies for bisphosphonates in the management of postmenopausal osteoporosis: patient considerations

Clinical Interventions in Aging, 2008
John SunyeczMenopauseRx, Inc., Hopwood, PA, USAAbstract: Postmenopausal osteoporosis is common and underrecognized among elderly women. Osteoporotic fractures cause disability and disfigurement and threaten patients’ mobility, independence, and ...
John Sunyecz
doaj   +1 more source

Extended interval dosing strategies in multiple sclerosis: insights from natalizumab and ocrelizumab trials. [PDF]

J Neurol
Recent advances in the treatment of relapsing multiple sclerosis (RRMS) have seen the emergence of a wide range of high efficacy disease-modifying therapies (DMTs) including natalizumab and ocrelizumab, which are now well embedded in routine clinical ...
Zid Y, Robertson NP.
europepmc   +2 more sources

Pharmacokinetics of aminoglycoside antibiotics. Based on population pharmacokinetic data determination of the loading dose, maintenance dose and dosage interval [PDF]

Farmacja Polska, 2021
Aminoglycosides are natural or semisynthetic antibiotics derived from actinomycetes. They bind to the bacterial ribosome, leading to inhibition of protein synthesis.
Arkadiusz Gruchlik, Marcin Kochan
doaj   +1 more source