Results 111 to 120 of about 1,499,695 (288)

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Study on extended reality enhancement technology in 5G-Advanced

Dianxin kexue
With the rise of the metauniverse, extended reality has become the multimedia application technology vigorously promoted by the industry. To realize extended reality, it is necessary to enhance the existing wireless network technology to meet the ...
XIAO Yang
doaj   +2 more sources

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Model Identification and Non-unique Structure [PDF]

Identification is an essential attribute of any model's parameters, so we consider its three aspects of 'uniqueness', 'correspondence to reality' and 'interpretability'.
David Hendry, Grayham E. Mizon, Maozu Lu
core  

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Extended Reality-Aware Wireless Communication Networks: A Systematic Literature Review

IEEE Open Journal of the Communications Society
Extended Reality (XR), encompassing virtual, augmented, and mixed reality systems, rapidly evolves across gaming, education, healthcare, and industry, with increasing reliance on wireless communications.
Esraa M. Ghourab, Mohamed Azab, Denis Gracanin, Omar Alhussein, Mahmoud Al-Qutayri, Sami Muhaidat   +5 more
doaj   +1 more source

Extended Reality & Virtual Reality for Return-to-Sports Screening

2024 IEEE Gaming, Entertainment, and Media Conference (GEM)
Anterior cruciate ligament (ACL) injuries are common in sports such as soccer, often requiring extensive rehabilitation post-surgery. Return-to-sport (RTS) rehabilitation protocols typically involve clinical and kinematic evaluations to ensure safety. This study investigates the added value of non-immersive (Extended Reality XR) and immersive (Virtual ...
Van Wallendael, Glenn, Artois, Julie, Mareen, Hannes, Capelleman, Robbe, Schuermans, Joke, Wezenbeek, Evi, Lambert, Peter   +6 more
openaire   +2 more sources

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

The bibliometric analysis of extended reality in surgical training: Global and Chinese perspective

Heliyon
Objectives: The prospect of extended reality (XR) being integrated with surgical training curriculum has attracted scholars. However, there is a lack of bibliometric analysis to help them better understand this field.
Wei Li, Siyuan Ma, Lei Zhou, Lars Konge, Junjun Pan, Jialiang Hui   +5 more
doaj   +1 more source