Results 131 to 140 of about 130,553 (304)

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Digitalizing Bank Branches with a New Multichannel Standard to Address Office Closures in Europe

The growing phenomenon of bank branch closures, driven by rising operational costs and the need to meet specific KPIs, is reducing access to banking services, especially in remote areas.
MERICO, B. M., VERGALLO, Roberto, CAIONE, A., MAINETTI, Luca, MATINO, Sara   +4 more
core  

NEXUS : Mixed Reality Experiments with Embodied Intentional Agents

, 2013
17th Annual Conference on Computer Animation and Social Agents (CASA2004), 7th-9th July, University of Geneva, SwitzerlandThis paper seeks to erode the traditional boundaries that exist between the physical and the virtual world.
Duffy, Brian R., O'Hare, G. M. P. (Greg M. P.), Campbell, Abraham G., O\u27Hare, G. M. P. (Greg M. P.)   +3 more
core  

The EXPERIENCE Project: Automatic virtualization of "extended personal reality" through biomedical signal processing and explainable artificial intelligence [Applications Corner] [PDF]

[EN] The transformation of communication media has revolutionized social interactions, incorporating audio and video into our lives. Despite the recent availability of virtual reality (VR) technology, its widespread adoption faces obstacles ...
Dudnik, G, Valenza, G, Rossi, S, Alcaniz, M, Provinciale, Jaime Guixeres, Gentili, C, Rossi, Simone, Valenza, Gaetano, Carli, Vladimir, Carli, V,, Toschi, N, Alcañiz Raya, Mariano Luis, Dudnik, Gabriela, Provinciale, JG, Toschi, Nicola, Gentili, Claudio, van, Wassenhove V, van Wassenhove, Virginie   +17 more
core   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

X-NR: Towards An Extended Reality-Driven Human Evaluation Framework for Neural-Rendering

The joint usage of Extended Reality (XR) and Artificial Intelligence (AI) has enabled different Metaverse-related use cases. Such paradigms were recently adopted for immersive content creation, particularly considering Neural Rendering (NR) techniques to
Pierdicca, Roberto, Paolanti, Marina, Frontoni, Emanuele, Gorgoglione, Lucrezia, Stacchio, Lorenzo, Balloni, Emanuele   +5 more
core   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source