Results 101 to 110 of about 18,849,427 (268)

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Multilevel structured low-density parity-check codes for AWGN and Rayleigh channels

, 2010
We propose a novel class of protograph low-density parity-check (LDPC) codes having a combinatorial rather than a random structure, which are termed multilevel-structured (MLS) LDPC codes. It is demonstrated that they posses a strikingly simple structure
Chen, Sheng, Bonello, Nicholas, Hanzo, Lajos   +2 more
core   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Development of Reduced Order Model for Steady State Flow Field in Two-dimensional Lower Plenum

Yuanzineng kexue jishu
In the field of reactor thermal-hydraulics, system thermal-hydraulic codes have been widely employed to quickly determine the global response characteristics of the primary system.
SHANG He1, PENG Minjun1, 2, XIA Genglei1, 2, , ZHANG Shiqi1, ZHU Shijie1
doaj   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Advanced Model with a Trajectory Tracking Stabilisation System and Feasible Solution of the Optimal Control Problem

Mathematics
In this study, we consider the extended optimal control problem and search for a control function in the class of feasible functions for a real control object. Unlike the classical optimal control problem, the control function should depend on the state,
Askhat Diveev, Elena Sofronova, Nurbek Konyrbaev, Oralbek Abdullayev   +3 more
doaj   +1 more source

The extended codes of some linear codes

The classical way of extending an [n,k,d] linear code C is to add an overall parity-check coordinate to each codeword of the linear code C. This extended code, denoted by C‾(−1) and called the standardly extended code of C, is a linear code with ...
Ding, Cunsheng, Sun, Zhonghua, Chen, Tingfang   +2 more
core   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Exploring Jalisco's water quality: A comprehensive web tool for limnological and phytoplankton data

Geoscience Data Journal
This study presents a comprehensive dataset of hydrological information gathered from five key eastern basins in Jalisco, Mexico. The dataset encompasses approximately 50 limnological variables and phytoplankton counts specifically for one of these ...
Cristofer Camarena‐Orozco, Eduardo Juárez Carrillo, Martha Alicia Lara González, Edlin Guerra‐Castro   +3 more
doaj   +1 more source

Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk

Molecular Oncology, EarlyView.
Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley   +1 more source