Results 191 to 200 of about 1,013 (224)

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

ESO-Based Non-Singular Terminal Filtered Integral Sliding Mode Backstepping Control for Unmanned Surface Vessels. [PDF]

Sensors (Basel)
Yuan J, Chai Z, Chen Q, Dong Z, Wan L.
europepmc   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

Simulation control analysis of a magnetic levitation flywheel rotor system based on a fuzzy PID control algorithm. [PDF]

Sci Rep
Dong W, Zhang B, Luo J.
europepmc   +1 more source

Active Disturbance Rejection Control for an automotive suspension system based on parameter tuning using a fuzzy technique. [PDF]

PLoS One
Nguyen TA.
europepmc   +1 more source

Target-tracking control method for autonomous vehicles based on hyperbolic-tangent line-of-sight guidance and odometry error compensation. [PDF]

PLoS One
Liu X, Zhu H, Shan Z, Lu Q, He L.
europepmc   +1 more source

A double closed loop digital hydraulic cylinder position system based on switching active disturbance rejection control. [PDF]

Sci Rep
Jiang S, Zhao G, Huang F, Liu W, Chen Y, Zhang L.   +5 more
europepmc   +1 more source

Design and Development of a Precision Spraying Control System for Orchards Based on Machine Vision Detection. [PDF]

Sensors (Basel)
Luo Y, He X, Shi H, Yang SX, Song L, Li P.   +5 more
europepmc   +1 more source

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The research of the novel bearingless levitation system based on Extended State Observer (ESO)

2011 International Conference on Electrical Machines and Systems, 2011
At present, the classical control strategy of PID is widely adopted in the bearingless levitation system. However, it is hard to realize high performance of levitation control, due to the influence of disturbance, parameters perturbation etc. Aiming at the problem above, the novel bearingless levitation system based on Extended State Observer (ESO) is ...
Peng He, Xiaolin Wang
openaire   +1 more source