Results 251 to 260 of about 784,857 (332)

TRIM47 Regulates Energy Metabolism via Glycolytic Reprogramming to Drive Hepatocellular Carcinoma Progression and Represents an Efficient Therapeutic Target

Advanced Science, EarlyView.
This study identifies TRIM47 as a key driver of liver cancer progression by promoting glycolysis through ubiquitin‐mediated degradation of the gluconeogenic enzyme FBP1. TRIM47 enhances glucose uptake, lactate and ATP production, and tumor growth and metastasis.
Weijie Sun, Yihang Yuan, Qian Qiu, Kexuan Tan, Xutong Li, Haotian Li, Luyang Kang, Yuting Gu, Ziheng Zhang, Jiayu He, Jiali Li, Junjie Lin, Zihan Xie, Kexing Han, Jiabin Li, Yang Zhang, Ting Wu, Yufeng Gao   +17 more
wiley   +1 more source

Digital Catalysts for Noncommunicable Disease Prevention Serious Games and Gamified Applications: Framework Design Study.

JMIR Serious Games
Aigner C, Baranyi R, Grechenig T.
europepmc   +1 more source

An adaptive dynamics framework for microbial ecology and evolution. [PDF]

Sci Rep
Karlsson CJ, Gerlee P, Rowlett J.
europepmc   +1 more source

Midbrain PAG Astrocytes Modulate Mouse Defensive and Panic‐Like Behaviors

Advanced Science, EarlyView.
Astrocytes in the midbrain periaqueductal gray (PAG) dynamically encode threat intensity and shape defensive action selection in mice. Real‐time Ca2+ imaging reveals robust astrocytic activation during predator odor and CO2 exposure. Aberrant astrocytic Ca2+ overactivation disrupts goal‐directed escape, biases behavior toward freezing, and induces ...
Ellane Barcelon, Kyungchul Noh, Minkyu Hwang, Yoon‐Jung Kim, Unjin Lee, Yeon Joo Ryu, Je‐Kyung Ryu, Sang Beom Jun, Se‐Young Choi, Woo‐Hyun Cho, Sung Joong Lee   +10 more
wiley   +1 more source

The effect of organizational differentiation in football training on young football players. [PDF]

Front Psychol
Størdal O, Dalen T, Lagestad P.
europepmc   +1 more source

Modifying Glucose Metabolism Reverses Memory Defects of Alzheimer's Disease Model at Late Stages

Advanced Science, EarlyView.
Using spatial transcriptomics, we show that ferul enanthate (SL‐ZF‐01) reverses episodic‐like memory deficits in aged, but not young, Alzheimer’s disease (AD) mice. SL restores glucose metabolism and Glucose Transporter 1/3 expression via an ‘Aging‐AD‐Rescue’ pattern, rescuing deficits seen in aged AD mice.
Fang Liu, Yiyu‐Li Tang, Zong‐Bo Zhang, Ya‐Hong Tan, Si‐Hui Lin, Ni‐Ya Wang, Jin‐Nan Li, Zhi‐Jie Pan, Jian‐Feng Li, Jing‐Fei Huang, Yu‐Qiang Ding, Chun‐Ming Guo, Lin Xu, Cheng Peng, Qi‐Xin Zhou   +14 more
wiley   +1 more source

The Relationship Between the Functional Head Impulse Test (F-HIT) and Digital Gaming Addiction in Adolescents. [PDF]

Children (Basel)
Cengiz DU, Çolak SC, Kay MA, Kurtcu B, Sağlam M, Duran M, Çelik OT.   +6 more
europepmc   +1 more source

Cost-effectiveness analysis of the MYO Armband^® device in combination with specifically designed video games for upper limb rehabilitation in people with multiple sclerosis. [PDF]

J Neuroeng Rehabil
Marcos-Antón S, Cano-de-la-Cuerda R, Aranda-Reneo I, Jardón-Huete A, Oña-Simbaña ED, Oliva-Moreno J.   +5 more
europepmc   +1 more source

Insomnia severity and its association with gaming behavior and perceived health in autistic adults. [PDF]

BMC Psychol
Bouder S, K McNulty L, Lee D.
europepmc   +1 more source

Ethical aspects of the application of artificial intelligence in psychiatry. [PDF]

Postep Psychiatr Neurol
Stępień M, Silczuk A.
europepmc   +1 more source