Results 31 to 40 of about 23,332 (236)

Second-line drug resistance among multidrug-resistant tuberculosis patients in Ethiopia: A laboratory-based surveillance

Journal of Global Antimicrobial Resistance
Objectives: To estimate the proportion of second-line anti-tuberculosis drug resistance among multidrug-resistant tuberculosis (MDR-TB) patients in Ethiopia.
Getu Diriba, Ayinalem Alemu, Bazezew Yenew, Betselot Zerihun Ayano, Michael Hailu, Bedo Buta, Amanuel Wondimu, Zigba Tefera, Abyot Meaza, Getachew Seid, Muluwork Getahun, Biniyam Dagne, Hilina Mollalign, Yeshiwork Abebaw, Melak Getu, Mengistu Tadesse, Tegegn Belhu, Ephrem Alemu, Minilik Demissie, Ashenafi Erresso, Getachew Aga, Andargachew Kumsa, Taye Letta, Saro Abdella, Shewki Moga, Mesay Hailu Dangisso, Getachew Tollera, Gemechu Tadesse   +27 more
doaj   +1 more source

Issues of Tuberculosis Drug-Resistance in Kharkiv Region and in Ukraine

Infusion & Chemotherapy, 2019
Background. Multidrug-resistant tuberculosis and extensively drug-resistant tuberculosis remain severe epidemic problems in the world. That’s why the purpose of our study was to investigate the dynamics of the incidence of multidrug-resistant and ...
O.S. Shevchenko, O.O. Pohorielova
doaj   +1 more source

AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury

, 2022
Hepatology, EarlyView.
Robert J. Fontana, Iris Liou, Adrian Reuben, Ayako Suzuki, M. Isabel Fiel, William Lee, Victor Navarro   +6 more
wiley   +1 more source

Extensively drug resistant tuberculosis in Mali: a case report

BMC Research Notes, 2017
Background Drug resistant tuberculosis presents a major public health challenge. Case presentation We present here the first two patients diagnosed with extensively drug resistant tuberculosis in Bamako, Mali.
Bassirou Diarra, Yacouba Toloba, Bakary Konate, Moumine Sanogo, Antieme Combo Georges Togo, Fatimata Camara, Gaoussou Berthe, Dianguina Soumaré, Bocar Baya, Drissa Goita, Yeya dit Sadio Sarro, Mamoudou Maiga, Michael Belson, Susan Orsega, Sounkalo Dao, Robert L. Murphy, Sophia Siddiqui, Bouke C. de Jong, Seydou Doumbia, Souleymane Diallo   +19 more
doaj   +1 more source

Culture conversion at six months in patients receiving bedaquiline- and delamanid-containing regimens for the treatment of multidrug-resistant tuberculosis

International Journal of Infectious Diseases, 2021
Rifampicin-resistant/multidrug-resistant (RR/MDR) and extensively drug-resistant (XDR) strains of M. tuberculosis (TB) are serious public health problem in Kazakhstan.
Shynar M. Maretbayeva, Anar S. Rakisheva, Malik M. Adenov, Lyazzat T. Yeraliyeva, Yerkebulan Zh. Algozhin, Assel T. Stambekova, Elmira A. Berikova, Askar Yedilbayev, Michael L. Rich, Kwonjune J. Seung, Assiya M. Issayeva   +10 more
doaj   +1 more source

Bacteria‐Responsive Nanostructured Drug Delivery Systems for Targeted Antimicrobial Therapy

Advanced Materials, EarlyView.
Bacteria‐responsive nanocarriers are designed to release antimicrobials only in the presence of infection‐specific cues. This selective activation ensures drug release precisely at the site of infection, avoiding premature or indiscriminate release, and enhancing efficacy.
Guillermo Landa, Gracia Mendoza, Silvia Irusta, Manuel Arruebo   +3 more
wiley   +1 more source

RNA Helicase DDX21 Controls CD4+ T Cell Proliferation and Promotes Inflammatory Bowel Disease via Translational Control

Advanced Science, EarlyView.
ABSTRACT Inflammatory bowel disease (IBD) is characterized by dysregulated T cell responses. RNA helicases, including DExD‐box helicase 21 (DDX21), are pivotal in RNA metabolism, but their role in T cell‐mediated pathology during IBD remains unclear. Here, we demonstrate that DDX21 expression in CD4+ T cells correlates with cell cycle and translation ...
Yujuan Zhang, Chen Kan, Xinhui Yang, Yajuan Hao, Xuemin Cai, Mei Yang, Qianqian Zhang, Zhengting Wang, Ning Jiang, Lei Wang, Hua‐Bing Li, Jing Zhou   +11 more
wiley   +1 more source

SERS Facemask for Rapid and Portable Sensing Mycobacterium Tuberculosis Antigens for TB Screening

Advanced Science, EarlyView.
Our study introduced an Au─Ag embedded covalent organic framework (U@COF) ‐mediated facemask for sensing TB antigen ESAT‐6/CFP‐10 complex in clinical droplet samples toward TB screening. Practical analysis of clinical samples demonstrated the availability of our facemask, which is capable of identifying the TB subjects (N = 17) from healthy candidates (
Lingzhi Chen, Jiaqi Yu, Jing Xu, Lingqi Chen, Ninghao Zhang, Wenrui Li, Runmin Zeng, Xiaomin Luo, Yiqun Chang, Jiayin Lai, Wenshi Huang, Xiaochen Liang, Ting Zhao, Shanze Chen, Huaihong Cai, Yanguang Cong, Pinghua Sun, Jiang Pi, Xueqin Huang, Haibo Zhou, Junxia Zheng   +20 more
wiley   +1 more source

Efficacy and safety data on pretomanid for drug-resistant TB

IJTLD Open
OBJECTIVE: To summarise the efficacy and safety of pretomanid (Pa) based regimens in patients with drug-resistant TB (DR-TB). METHODS: We included clinical trials, operational research and observational studies reporting the efficacy and safety of Pa ...
H.T.T. Thuy, C. Padmapriyadarsini, C. Chuchottaworn, S. Foraida, S. Hadigal, A.R. Birajdar   +5 more
doaj   +1 more source

Adverse treatment outcomes in multidrug resistant tuberculosis go beyond the microbe-drug interaction: Results of a multiple correspondence analysis.

Biomédica: revista del Instituto Nacional de Salud, 2020
Introduction: Multidrug-resistant tuberculosis treatment is effective in 50% of patients due to several factors including antibiotic susceptibility of the microorganism, adverse treatment reactions, social factors, and associated comorbidities ...
Ángela Tobón, Johana Rueda, Diego H. Cáceres, Gloria I. Mejía, Elsa M. Zapata, Fernando Montes, Antonio Ospina, Santiago Fadul, Lizeth Paniagua, Jaime Robledo   +9 more
doaj   +1 more source