Results 91 to 100 of about 11,026 (316)

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source

Internalism as Methodology

Biolinguistics, 2009
This paper scrutinizes the recent proposal made by Lassiter (2008) that the dichotomy between Chomskyan internalism and Dummett-type externalism is misguided and should be overcome by an approach that incorporates sociolinguistic concepts such as ...
Terje Lohndal, Hiroki Narita
doaj   +1 more source

Review of Rob Wilson’s Boundaries of the Mind: The Individual in the Fragile Sciences: Cognition [PDF]

, 2006
Review of Rob Wilson’s Boundaries of the Mind: The Individual in the Fragile Sciences ...
Marsh, Leslie
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YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma

Molecular Oncology, EarlyView.
The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy, Samuel Hartzler, Paula A. Vargas Carranza, Shyaman Jayasundara, Madison E. Yates, Nimod D. Janson, Bozhi Liu, Annaleigh Benton, Majid Kazemian, Jason A. Hanna   +9 more
wiley   +1 more source

Hilary Putnam (1926-2016): A Lifetime Quest to Understand the Relationship between Mind, Language, and Reality [PDF]

, 2016
This is an extended intellectual obituary for Hilary ...
Anderson, David Leech
core  

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Luka eksplanacyjna a pojęcia własności fenomenalnych stanowisko Josepha Levine’a ( Explanatory gap and the concept of phenomenal properties: Joseph Levine’s view) [PDF]

Analiza i Egzystencja, 2012
The explanatory gap problem arises in the context of the mind-body relation, and especially the phenomenal concepts-physical concepts relation. It is posed as a question about the method which is appropriate for the reduction of consciousness to physical
Adriana Schetz
doaj  

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

A Critical Evaluation on the Epistemological Externalist Ground of Scientism in the Context of Epistemic Concern

Felsefe Arkivi
Scientism is a philosophical approach that asserts that the scientific method is the only way to acquire knowledge. Since the scientific method only assumes material reality, scientism is inherently a materialistic and naturalistic philosophy that ...
Alper Gürkan
doaj   +1 more source

Justification [PDF]

, 2018
In the most general sense, the term“justification” refers to the act of providing reasons for the validity, legitimacy, and defensibility of (1) an action, (2) a belief, and/or (3) a social arrangement.
Susen, S.
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