Results 71 to 80 of about 11,159 (315)
AAA+ protein unfoldases—the Moirai of the proteome
FEBS Letters, EarlyView.AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley +1 more source
Luka eksplanacyjna a pojęcia własności fenomenalnych stanowisko Josepha Levine’a ( Explanatory gap and the concept of phenomenal properties: Joseph Levine’s view) [PDF]
Analiza i Egzystencja, 2012 The explanatory gap problem arises in the context of the mind-body relation, and especially the phenomenal concepts-physical concepts relation. It is posed as a question about the method which is appropriate for the reduction of consciousness to physical
Adriana Schetz
doaj
Necessity and Liability: On an Honour-Based Justification for Defensive Harming [PDF]
, 2016 This paper considers whether victims can justify what appears to be unnecessary defensive harming by reference to an honour-based justification. I argue that such an account faces serious problems: the honour-based justification cannot permit, first ...
Bowen, Joseph
core +1 more source
, 2009 We initiate the study of sublinear-time algorithms in the external memory model [1]. In this model, the data is stored in blocks of a certain size B , and the algorithm is charged a unit cost for each block access. This model is well-studied, since it reflects the computational issues occurring when the (massive) input is stored on a disk.
Andoni, Alexandr +3 more
openaire +3 more sources
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
AGAINST PHENOMENAL EXTERNALISM
Crítica, 2017 We maintain that no extant argument in favor of phenomenal external- ism (PE) is really convincing. PE is the thesis that the phenomenal properties of our experiences must be individuated widely insofar as they are constituted by worldly properties.
ELISABETTA SACCHI, ALBERTO VOLTOLINI
doaj
Felsefe ArkiviScientism is a philosophical approach that asserts that the scientific method is the only way to acquire knowledge. Since the scientific method only assumes material reality, scientism is inherently a materialistic and naturalistic philosophy that ...
Alper Gürkan
doaj +1 more source
O pensamento sem estaca zero (A mentalidade externalista e as razões nossas de cada dia)
Kriterion, 2004 O reconhecimento de uma autoridade (de fatos, de observações compartilhadas, de princípios comumente aceitos etc.) por parte de quem se convence é o que buscamos quando nos engajamos em uma prática de oferecer razões para um pensamento ou uma ação ...
Hilan Bensusan
doaj +1 more source
FEBS Letters, EarlyView.Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure +3 more
wiley +1 more source