Results 61 to 70 of about 4,293 (244)

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Świadomość fenomenalna a problem intencjonalności. O intencjonalności fenomalnej (Phenomenal Consciousness and the Problem of Intentionality. About Phenomenal Intentionality) [PDF]

Analiza i Egzystencja, 2011
The article concerns the problem of how to understand the relationship between phenomenal consciousness and intentionality or mental content – an issue that, until recently, has been neglected by many analytic philosophers of mind. I distinguish two ways
Paweł Gładziejewski
doaj  

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Externalism about reasons and the problem of reasonable disagreement: a hybridist solution

Ethic@: an International Journal for Moral Philosophy
This paper investigates the challenges that externalism about reasons faces in accounting for the source of practical normativity, with particular emphasis on the problem of reasonable disagreement.
Lucas Mateus Dalsotto
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Towards an Enlightened Externalism: A Demystification of the Internalism Externalism debate [PDF]

, 2015
The Paper argues for the synthesis of the Internalism and Externalism theory of justification. It is the opinion of the paper that since both internalist and externalists legitimately seeks the epistemic quest for certainty, both are important ...
Oyekunle, Akinpelu Ayokunnu, Akinpelu Ayokunnu, Oyekunle   +1 more
core   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Evidential Externalism [PDF]

, 2018
It is widely accepted, amongst epistemologists, that evidence plays an important role in our epistemic life. Crucially, there is no agreement on what evidence is. Following Silins, we can cash out the disagreement around the notion of evidence in terms
Fratantonio, Giada
core