Results 81 to 90 of about 11,026 (316)

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Davidson's Externalism and Swampman's Troublesome Biography

Principia: An International Journal of Epistemology, 2005
After the seminal works of Putnam (1975), Burge (1979), and Kripke (1982), the next important contribution to externalism is certainly Davidson’s (mainly 1987, 1988, 1989, 2001).
André Leclerc
doaj  

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Hierarchy Theory of Evolution and the Extended Evolutionary Synthesis: Some Epistemic Bridges, Some Conceptual Rifts [PDF]

, 2018
Contemporary evolutionary biology comprises a plural landscape of multiple co-existent conceptual frameworks and strenuous voices that disagree on the nature and scope of evolutionary theory.
A Etxeberria, A Fuentes, A Parravicini, A Vianello, A Wagner, AC Love, Alejandro Fábregas-Tejeda, AV Badyaev, B Bocxlaer Van, BS Lieberman, BS Lieberman, D Noble, D Sepkoski, D Sloan-Wilson, DD Turner, DJ Depew, DJ Futuyma, DJ Nicholson, DL Hull, DM Walsh, DR Piperno, DT Campbell, E Danchin, E Jablonka, E Jablonka, E Jablonka, E Mayr, E Mayr, E Serrelli, E Szathmáry, EI Svensson, ES Vrba, ES Vrba, ES Vrba, F Suman, F Vergara-Silva, FJ Odling-Smee, FJ Odling-Smee, Francisco Vergara-Silva, GB Müller, GB Müller, GG Simpson, GJ Cooper, GP Wagner, GP Wagner, I Tëmkin, I Tëmkin, I Tëmkin, J Beatty, J Griesemer, J Griesemer, J Odling-Smee, J Odling-Smee, JJ Welch, JW Pepper, K Laland, K Laland, K Stotz, KN Laland, KN Laland, KN Laland, KN Laland, M Bertolaso, M Blute, M Lynch, M Martínez, M Nei, M Pavličev, M Pigliucci, M Pigliucci, MD Laubichler, MJ Denton, MW Kirschner, N Eldredge, N Eldredge, N Eldredge, N Eldredge, N Eldredge, N Eldredge, N Eldredge, N Eldredge, P Alberch, P Bateson, P Godfrey-Smith, PJ Bowler, R Amundson, R Amundson, R Riedl, R Sansom, RG Delisle, RG Winther, S Caianiello, S Okasha, S Okasha, S Oyama, S Sultan, SF Gilbert, SJ Gould, SJ Gould, T Ingold, T Ingold, T Pievani, T Pievani, T Pievani, T Pievani, TA Grantham, TS Kemp, TS Kemp, U Dieckmann, W Miller III, W Miller III, WB Provine, WD Allmon, WE Reif   +113 more
core   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

Structuralism as a Response to Skepticism [PDF]

, 2018
Cartesian arguments for global skepticism about the external world start from the premise that we cannot know that we are not in a Cartesian scenario such as an evil-demon scenario, and infer that because most of our empirical beliefs are false in such a
Chalmers, David J.
core  

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira, Anna Skwarska, Karolina Chwialkowska, Agnieszka Ostrowska, Gabriela Sokolowska, Anna Zeller, Anna Erol, Andrzej Eljaszewicz, Bartosz Hanczaruk, Anna Michalska‐Falkowska, Agnieszka Tarasik, Joanna Reszec‐Gielazyn, Pawel Knapp, Marcin Moniuszko, Adam Kretowski   +14 more
wiley   +1 more source

Les gestes dans l’environnement numérique : la ponctuation des affects

Revue Française des Sciences de l’Information et de la Communication, 2017
Through the prism of an anthropological approach inspired by the externalist Theory, I propose to study the way digital tools have an impact on the morphology and rhythms of affects.
Peppe Cavallari
doaj   +1 more source

External adjustment [PDF]

Review of World Economics, 2004
Gross stocks of foreign assets have increased rapidly relative to national outputs since 1990, and the short-run capital gains and losses on those assets can amount to significant fractions of GDP. These fluctuations in asset values render the national income and product account measure of the current account balance increasingly inadequate as a ...
openaire   +3 more sources