Results 121 to 130 of about 2,634,864 (332)
Molecular Oncology, EarlyView.This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani +14 more
wiley +1 more source
THE EXTRACELLULAR RELEASE OF ECHINOCHROME [PDF]
Journal of General Physiology, 1946 A study was made of the diffusion of the red pigment echinochrome from the eggs of the sea urchin, Arbacia punctulata, into sea water. Unfertilized eggs retained their pigment, over periods of hours. Outward diffusion of pigment from unfertilized eggs normally is entirely negligible, or does not occur at all.
openaire +4 more sources
Molecular Oncology, EarlyView.This study investigates gene expression differences between two major pediatric acute lymphoblastic leukemia (ALL) subtypes, B‐cell precursor ALL, and T‐cell ALL, using a data‐driven approach consisting of biostatistics and machine learning methods. Following analysis of a discovery dataset, we find a set of 14 expression markers differentiating the ...
Mona Nourbakhsh +8 more
wiley +1 more source
PKQuest: PBPK modeling of highly lipid soluble and extracellular solutes
ADMET and DMPK, 2019 One of the primary objectives of physiologically based pharmacokinetics (PBPK) is the prediction of a drug’s pharmacokinetics just from knowledge of its physicochemical structure.
David G. Levitt
doaj +1 more source
Extracellular Matrix (ECM) [PDF]
, 2012 The region of space at the periphery of cyanobacterial cells is the interface between the environment and intracellular processes. This metaspace may include a structure appressed to the outer wall and membrane, such as an extracellular polysaccharide (EPS), a structural and/or physiological discontinuity in the control of flow metabolites, as well as ...
Helm R.F., Potts M.
openaire +4 more sources
Molecular Oncology, EarlyView.The pan‐HDAC inhibitor belinostat increases the expression of the pro‐apoptotic proteins Bim, Puma, and Noxa and induces apoptosis in ovarian cancer cell lines and patient‐derived tumor organoids when used at high concentrations. Moreover, inhibiting the anti‐apoptotic proteins Bcl‐xL or Mcl‐1 sensitizes these preclinical models to the cytotoxic effect
Cécilia Thomine +10 more
wiley +1 more source
Molecular Oncology, EarlyView.The COMBAT classification system, developed through multi‐omics integration, stratifies adult patients with B‐cell acute lymphoblastic leukemia(B‐ALL) into three molecular subtypes with distinct surface antigen patterns, immune landscape, methylation patterns, biological pathways and prognosis.
Yang Song +11 more
wiley +1 more source
Metabolites, 2019 Cyanobacteria have many defence strategies to overcome harmful ultraviolet (UV) stress including the production of secondary metabolites. Metabolomics can be used to investigate this altered metabolism via targeted and untargeted techniques.
Bethan Kultschar +3 more
doaj +1 more source
BLOOD AND EXTRACELLULAR FLUID STUDIES IN CHRONIC MALNUTRITION IN INFANCY 12 [PDF]
, 1948 Frank Gollan
openalex +1 more source