Results 151 to 160 of about 1,944,890 (372)
Molecular Oncology, EarlyView.Pancreatic ductal adenocarcinoma (PDAC) is a disease with very poor prognosis due to therapeutic limitations. We investigated the antitumor effects of cystatin A (CSTA) in PDAC murine models. We are first to confirm that CSTA enhances T helper type 1‐mediated antitumor effects through promotion of dendritic cells and M1 macrophage activity. CSTA can be
Alessandro Nasti +8 more
wiley +1 more source
Extracellular-to-intracellular signal transfer via G-proteins [PDF]
arXiv, 2005 We look at the problem of signal transduction by extracellular agonist binding to a receptor protein at the membrane (sensor) via binding of G-proteins (effectors) to a highly integrative target molecule, such as the second messenger cAMP (target). We explore the effects of binding times, effector assignment and effector pool size on the shape of the ...
arxiv
Extracellular vesicles and nanoparticles: emerging complexities.
Trends in Cell Biology, 2023 Dennis K. Jeppesen +3 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.Prostate cancer is a leading malignancy with significant clinical heterogeneity in men. An 11‐gene signature derived from dysregulated epithelial cell markers effectively predicted biochemical recurrence‐free survival in patients who underwent radical surgery or radiotherapy.
Zhuofan Mou, Lorna W. Harries
wiley +1 more source
The assimilation of amino-acids by bacteria. 13. The effect of certain amino-acids on the accumulation of free glutamic acid by Staphylococcus aureus: extracellular peptide formation [PDF]
, 1951 E. F. Gale, Marguerite B. Van Halteren
openalex +1 more source
The role of extracellular vesicles in cancer
Cell, 2023 R. Kalluri, Kathleen M. McAndrews
semanticscholar +1 more source
Clinical significance of stratifying prostate cancer patients through specific circulating genes
Molecular Oncology, EarlyView.We tested a specific panel of genes representative of luminal, neuroendocrine and stem‐like cells in the blood of prostate cancer patients, showing predictive value from diagnosis to late stages of disease. This approach allows monitoring of treatment responses and outcomes at specific time points in trajectories.
Seta Derderian +12 more
wiley +1 more source
A press-to-contact acoustic sensor for measuring elasticity and ageing of extracellular matrix [PDF]
arXiv, 2018 We report an acoustic approach to measure the elastic properties of an extracellular matrix (ECM). This approach uses a short range evanescent waves to inject sound into the test material over a short distance using an electroded quartz crystal, also known as a quartz crystal microbalance (QCM).
arxiv
Molecular Oncology, EarlyView.MET variants in the N‐lobe of the kinase domain, found in hereditary papillary renal cell carcinoma, require ligand stimulation to promote cell transformation, in contrast to other RTK variants. This suggests that HGF expression in the microenvironment is important for tumor growth in such patients. Their sensitivity to MET inhibitors opens the way for
Célia Guérin +14 more
wiley +1 more source
Global existence results for complex hyperbolic models of bacterial chemotaxis [PDF]
arXiv, 2006 Bacteria are able to respond to environmental signals by changing their rules of movement. When we take into account chemical signals in the environment, this behaviour is often called chemotaxis. At the individual-level, chemotaxis consists of several steps. First, the cell detects the extracellular signal using receptors on its membrane.
arxiv