Results 171 to 180 of about 1,664,773 (248)

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

Bibliometric analysis of extracellular vesicles in osteoarthritis [PDF]

Ga Liao, Huixu Xie, Lin Kang, Lin Zhao, Weikun Meng   +4 more
openalex   +1 more source

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

Aging and Cancer, EarlyView.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey, Murilo Ramos Rocha, Cheyenne Palm, Vania Wang, Denys Balandin, Ethan Black, Kevin Y. Zhang, Fan Huang, Daniel J. Zabransky, Yash Chhabra, Mareike Peters, Gabriel Ghiaur, Ashani Weeraratna   +12 more
wiley   +1 more source

Editorial to the special issue on extracellular vesicles and mitochondria in CNS function and disease. [PDF]

J Cereb Blood Flow Metab
Hayakawa K, Hermann DM.
europepmc   +1 more source

The Aging Blood: Cellular Origins, Circulating Drivers, and Therapeutic Potential

Aging and Cancer, EarlyView.
As a conduit linking all organs, the blood system both reflects and actively drives systemic aging. This review highlights how circulating pro‐aging and antiaging factors and age‐associated hematopoietic stem cell dysfunction contribute to immunosenescence and multi‐organ decline, positioning the hematopoietic system as a target for aging intervention.
Hanqing He, Jianwei Wang
wiley   +1 more source

Extracellular Vesicles and the Gartner Hype Cycle. [PDF]

J Extracell Biol
Salehi M, Torabi S, Seydi H, Shekari F, Vosough M.   +4 more
europepmc   +1 more source

Systemic administration of induced pluripotent stem cell-derived mesenchymal stem cells improves cardiac function through extracellular vesicle-mediated tissue repair in a rat model of ischemic cardiomyopathy

Ryo Kawasumi, Takuji Kawamura, Kizuku Yamashita, Yuji Tominaga, Akima Harada, Emiko Ito, Maki Takeda, Shunbun Kita, Iichiro Shimomura, Shigeru Miyagawa   +9 more
openalex   +1 more source

Extracellular vesicles from long COVID patients promote RUNX2-mediated cellular stress via dysregulated miR-204 and p53 pathway activation [PDF]

Luca Dalle Carbonare, Arianna Minoia, Sharazed Zouari, Michele Braggio, Mattia Cominacini, Salvatore Calogero Gaglio, Francesca Cristiana Piritore, Pamela Lorenzi, Mirko Meneghel, Kevin Dervishi, Andrea Corsi, Anna Pedrinolla, Gaia Giuriato, Alessandra Fiore, Adriana Celesia, Laura Guerricchio, Massimo Venturelli, Federico Schena, Massimo Donadelli, Monica Mottes, Maria Grazia Romanelli, Massimiliano Perduca, Daniele Guardavaccaro, Ernesto Crisafulli, Donato Zipeto, Lucio Barile, Maria Teresa Valenti   +26 more
openalex   +1 more source

Cancer Cell Derived Small Extracellular Vesicles Contribute to Recipient Cell Metastasis Through Promoting HGF/c-Met Pathway* [PDF]

, 2019
Zhi Qiao, Yan Zhang, Maolin Ge, Sha Liu, Xiaoteng Jiang, Zhi Shang, Han Liu, Chengxi Cao, Hua Xiao   +8 more
openalex   +1 more source

Visual Recovery Reflects Cortical MeCP2 Sensitivity in Rett Syndrome

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Rett syndrome (RTT) is a devastating neurodevelopmental disorder with developmental regression affecting motor, sensory, and cognitive functions. Sensory disruptions contribute to the complex behavioral and cognitive difficulties and represent an important target for therapeutic interventions.
Alex Joseph Simon, Nathalie Picard, Valeria d'Andrea, Enchi Chang, Joseph Leffler, Eleonora Centofante, Matthew Taylor, Francesca Bardi, Francesca Cavicchiolo, Takao K. Hensch, Stefano Panzeri, Chinfei Chen, Michela Fagiolini   +12 more
wiley   +1 more source