Results 131 to 140 of about 28,000 (215)

Turning Cold Tumors Into Hot Tumors: Implications for Cancer Therapy

MedComm, Volume 7, Issue 8, August 2026.
Barrier‐defined strategies for cold‐to‐hot tumor conversion. Cold tumors include immune‐desert and immune‐excluded states marked by poor antigen visibility, limited T‐cell priming, stromal or vascular exclusion, metabolic stress and suppressive immune programs.
Xiao Ge, Dong Han, Jing Wang, Xinyu Dai, Chen Ma, Feihong Chen   +5 more
wiley   +1 more source

Amino Acid and Lipid Metabolism in Cancer: Mechanisms and Therapeutic Opportunities

MedComm, Volume 7, Issue 8, August 2026.
Amino Acid and lipid metabolism in cancer: (A) Regulation of Amino acid transportation and metabolism in cancer. (B) The core organization of lipid metabolic reprogramming in cancer and their functional consequences. ABSTRACT Metabolic reprogramming is a defining feature of cancer and a major contributor to immune escape.
Zixu Wang, Xin Fu, Jingchao Bai, Yanguo Liu, Kai Huang   +4 more
wiley   +1 more source

Type 2 Diabetes Mellitus: Molecular Pathogenesis and Therapeutic Interventions

MedComm, Volume 7, Issue 8, August 2026.
This graphical summary illustrates the multiorgan therapeutic landscape for Type 2 diabetes mellitus (T2D), integrating molecular pathogenesis with modern treatment strategies. It depicts how current interventions, including SGLT2 inhibitors, GLP‐1 receptor agonists, and insulin secretagogues, target key organs—kidney, pancreas, gastrointestinal tract,
Shinuan Fei, Xiyue Xiong, Lu Zhang, Jian Zhang, Lawrence W. C. Chan, Hong Jiang, Qingqing Xiong, Changtao Hu, Jie Chen, Sijun Yang   +9 more
wiley   +1 more source

Endocytotic uptake of HPMA-based polymers by different cancer cells: impact of extracellular acidosis and hypoxia. [PDF]

Int J Nanomedicine, 2017
Gündel D, Allmeroth M, Reime S, Zentel R, Thews O.   +4 more
europepmc   +1 more source

Preclinical 1H MRS Study of a Porcine Model Shows Evidence and Mechanisms for Acute Neuronal Injury in Neonatal Cardiopulmonary Bypass (CPB) Surgery

Magnetic Resonance in Medicine, Volume 96, Issue 2, Page 557-567, August 2026.
ABSTRACT Purpose Congenital heart disease affects 1% of US births, with some infants requiring cardiothoracic surgery under cardiopulmonary bypass (CPB). Optimal surgical parameters to minimize neuronal injury are unknown. We used serial 1H MRS in a neonatal CPB porcine model to assess acute neuronal damage and associated injury mechanisms.
Aaron Omon, Meng Gu, Ralph Hurd, Kirk Riemer, Frank Hanley, Daniel Spielman   +5 more
wiley   +1 more source

Metal‐Based Materials for Redox Modulation in Biomedicine

Rare Metals, Volume 45, Issue 8, August 2026.
ABSTRACT Metal materials have become increasingly important in modulating biological redox networks for therapeutic and diagnostic purposes, owing to their distinctive electronic properties and adaptable reactivity. This review synthesizes recent developments across various metal‐based materials, including elemental metals, metal oxides, coordination ...
Yan Fan, Jing Zhang, Ning Sun, Mengjie Chen, Li Sun, Jie Lin, Kang Chen, Haishan Zhang   +7 more
wiley   +1 more source

Microenvironment‐Responsive Drug Delivery Systems for Ocular Surface Diseases: Mechanisms, Applications, and Translational Challenges

Small Science, Volume 6, Issue 8, August 2026.
Microenvironment‐responsive drug delivery systems overcome ocular physiological barriers by responding to temperature, pH, ions, reactive oxygen species, and enzymes. This review bridges material design, performance evaluation, and clinical translation, offering actionable insights for treating dry eye disease, infectious keratitis, and corneal ...
Jiamin Liu, Liangbo Chen, Yao Fu, Siyi Zhang   +3 more
wiley   +1 more source

Ammonia Metabolism in the Aging Liver: Emerging Mechanistic Insights

Aging Cell, Volume 25, Issue 8, August 2026.
Liver aging may weaken ammonia‐detoxification reserve by disrupting mitochondrial ureagenesis, GS‐mediated scavenging, glutamine metabolism, and metabolic zonation. This emerging framework links impaired nitrogen handling to potential hepatic stress amplification and systemic crosstalk, while highlighting the need for direct validation in physiological
Heng Zhang, Guangyu Liang, Anding Liu
wiley   +1 more source

Priming of labor with tafoxiparin in nulliparous term pregnant women with unripe cervix—Proof‐of‐concept and dose‐finding results from a randomized controlled trial

Acta Obstetricia et Gynecologica Scandinavica, Volume 105, Issue 8, Page 1566-1577, August 2026.
This study shows that tafoxiparin 300 mg can increase the rate of cervical ripening and the likelihood of spontaneous onset of labor, while also reducing the duration of labor in women achieving spontaneous onset of labor. The favorable safety profile of tafoxiparin suggests suitability for routine clinical use, including home administration.
Gunvor Ekman‐Ordeberg, Maria Jonsson, Marie Blomberg, Malin Melin, Ylva Stjernholm‐Vladic, Sebastian B. Gidlöf, Dag Wide‐Swensson, Kati Tihtonen, Inge C. Olsen, Lena Degling‐Wikingsson, Per Blom, Leena Rahkonen   +11 more
wiley   +1 more source

Levetiracetam inhibits the Na+ HCO3− transporter Ncbe/NBCn2 (Slc4a10) in the choroid plexus of mice

Acta Physiologica, Volume 242, Issue 8, August 2026.
ABSTRACT Aim The Na+‐dependent Cl−/HCO3− exchanger Ncbe/NBCn2 (Slc4a10) constitutes a major basolateral HCO3− uptake pathway in the choroid plexus and contributes to cerebrospinal fluid secretion and pH regulation. This study examined whether levetiracetam inhibits Ncbe/NBCn2‐mediated transport and alters cerebrospinal fluid acid–base balance ...
Laura Øllegaard Johnsen, Lasse Messell Desdorf, Nicoline Stærke Jensen, Jeppe Praetorius, Helle Hasager Damkier   +4 more
wiley   +1 more source