Results 141 to 150 of about 28,000 (215)

Diltiazem N‐oxide, a novel ischaemia‐activated prodrug, prevents ischaemia‐induced ventricular fibrillation without off‐target adverse effects

British Journal of Pharmacology, Volume 183, Issue 16, Page 4646-4662, August 2026.
Abstract Background and Purpose Ventricular fibrillation (VF) in coronary heart disease accounts for up to 70% of sudden cardiac death. We examined whether diltiazem N‐oxide (DNO) has ischaemia‐selective antiarrhythmic activity. Experimental Approach Randomised and blinded experiments were performed in rat isolated hearts and in anaesthetised rats to ...
Louise M. Hesketh, Gabriel A. Watson, Francesca Mazzacuva, Zoe Hoare, Thomas R. Eykyn, Michael J. Curtis   +5 more
wiley   +1 more source

Altered Skeletal Muscle Phosphate Metabolism After Muscle Damage Is Associated With Elevated Effort Perception During Exercise in Humans

Scandinavian Journal of Medicine &Science in Sports, Volume 36, Issue 8, August 2026.
ABSTRACT It remains unclear why exercising damaged muscles is perceived as disproportionately more effortful. Given the known role of inorganic phosphate (Pi) in fatigue and afferent sensory signaling, we tested whether muscle damage disrupts phosphate metabolism and whether this is associated with heightened ratings of perceived exertion (RPE ...
Jamie Stewart McPhee, Aneurin James Kennerley, Jean‐Christophe Lagacé, James McStravick, Susan Pinner, Fabio Zambolin   +5 more
wiley   +1 more source

Brain sparing in fetal growth restriction: The double‐edged sword of fetal hypoxaemia

The Journal of Physiology, Volume 604, Issue 15, Page 6259-6280, 1 August 2026.
Abstract figure legend The double‐edged sword of brain sparing. Fetal hypoxaemia triggers a coordinated adaptive response characterised by redistribution of cardiac output toward essential organs, including the brain, and a reduction in overall metabolic activity to preserve oxygen supply.
Beth J. Allison, Tegan A. White, Emily J. Camm, Suzanne L. Miller   +3 more
wiley   +1 more source

Sphingosine-1-Phosphate Promotes FOS Activation in Osteosarcoma Under Tumor Acidosis. [PDF]

Acta Physiol (Oxf)
Bozzini N, Cortini M, Righi A, Grigoriadis AE, Dack M, Ilieva E, Torricelli F, Manicardi V, Baldini N, Avnet S.   +9 more
europepmc   +1 more source

Amino acid homeostasis in the kidney: Physiological roles and pathological dysregulation

Physiological Reports, Volume 14, Issue 15, August 2026.
Abstract Amino acids are fundamental to life as protein building blocks and key regulators of metabolism and signaling. The kidney plays a critical, yet underappreciated, role in amino acid homeostasis through three interconnected pillars: selective glomerular filtration, efficient tubular reabsorption, and metabolic processing, which includes de novo ...
Shuo Liu, Caifeng Shi, Yang Zhou, Chunsun Dai   +3 more
wiley   +1 more source

Intracellular lactic acidosis reprograms glycolysis and mitochondrial anaplerosis in cancer cells. [PDF]

J Biol Chem
Jin C, Zeng S, Wu H, Hu X.
europepmc   +1 more source

Investigating the Inhibitory Properties of Diazo and Pyrazole‐Carboxamide‐Linked Benzenesulfonamides Against Carbonic Anhydrase Isoforms I, II, IX, and XII

ChemMedChem, Volume 21, Issue 13, 14 July 2026.
Hybrid diazo‐ and pyrazole‐carboxamide benzenesulfonamides emerge as highly potent and selective inhibitors of tumor‐associated carbonic anhydrases. A 3,4‐dichloro‐substituted derivative achieves sub‐2 nM inhibition of hCA IX and displays promising anticancer activity, revealing a valuable scaffold for the development of next‐generation cancer‐targeted
Suleyman Akocak, Nebih Lolak, Andrea Ammara, Gökçenur Gürbüz, Ibrahim Bozgeyik, Demet Taşdemir, Hamada Hashem, Stefan Bräse, Claudiu T. Supuran   +8 more
wiley   +1 more source

Acidosis Regulates Microtubule Dynamics via the β1 Integrin/RhoA/CRMP-2 Axis. [PDF]

J Am Chem Soc
Lachowski D, Cortes E, Mykuliak V, Fernandez-de la Torre M, Bastida Urkiza A, Muñoz-Barrutia A, Garcia-Gonzalez D, Hytönen V, Del Rio Hernandez A.   +8 more
europepmc   +1 more source

Tumor Microenvironment Acidosis and Alkalization-Oriented Interventions in Advanced Solid Tumors: A Narrative Review and Science-Based Medicine Perspective on Long-Tail Survival. [PDF]

Cancers (Basel)
Suzuki K, Kachi S, Wada H.
europepmc   +1 more source

Acid-Base Dysregulation Links Aging Metabolism to Frailty. [PDF]

Aging Cell
Liao WH, Langhans W, Henneberg M.
europepmc   +1 more source