Results 211 to 220 of about 302,924 (260)
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Extracellular ATP, P2 receptors, and inflammation
Drug Development Research, 2003AbstractOver the past few years, P2 receptors have emerged as new potential players in the early phases of inflammation in their function of chemotactic receptors, triggers of proinflammatory cytokine release, and cytotoxic molecules. However, more recent data suggest that the role of P2 receptors in immunity is much more widespread and touches the ...
Di Virgilio F. +6 more
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Assessment of Extracellular ATP Concentrations
2009Most cells release ATP to the extracellular milieu. Extracellular ATP plays important signaling roles by activating a score of broadly distributed cell surface purinergic receptors (purinoceptors). Biological responses regulated by purinergic receptors include neurotransmission, smooth muscle relaxation and contraction, epithelial cell ion transport ...
Lucia, Seminario-Vidal +2 more
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Extracellular ATP and adenosine: The Yin and Yang in immune responses?
Molecular Aspects of Medicine, 2017Extracellular adenosine 5'-triphosphate (ATP) and adenosine molecules are intimately involved in immune responses. ATP is mostly a pro-inflammatory molecule and is released during hypoxic condition and by necrotic cells, as well as by activated immune cells and endothelial cells.
Faas, M., Sáez, Tamara, De Vos, P.
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Extracellular ATP signaling and clinical relevance
Clinical Immunology, 2018Since purinergic signaling was discovered in the early 1970s, it has been shown that extracellular nucleotides, and their derivative nucleosides, are released in a regulated or unregulated manner by cells in various challenging settings and then bind defined purinergic receptors to activate intricate signaling networks.
Lei Dou +3 more
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Modulation of myocardial activity by extracellular ATP
Trends in Cardiovascular Medicine, 1994Extracellular ATP, at micromolar concentration, induces multiple functional changes in cardiac cells. Stimulation of P(2) purinoceptors is associated with Ca current increase and positive inotropic effect. On rapid application, ATP triggers membrane depolarization by activating a Cl conductance and by inducing an acidification following Cl-HCO(3 ...
G, Vassort, M, Pucéat, F, Scamps
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Effects of Extracellular ATP on Mononuclear Phagocytes
Annals of the New York Academy of Sciences, 1990Vedi ...
Steinberg TH +4 more
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Intensification of ciliary motility by extracellular ATP
Biorheology, 1988Ciliary metachronism and motility were examined optically in tissue cultures from frog palate e:Rithelium as. a func.tion of extracellular ATP concentration in the range of 10−7–10−3M. The main findings were: a) upon addition of ATP the metachronal wavelength increased by a factor of up to 2.
D, Ovadyahu, D, Eshel, Z, Priel
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Identification of a Plant Receptor for Extracellular ATP
Science, 2014ATP Receptor in Arabidopsis As well as its role as an intracellular energy source, extracellular adenosine triphosphate (ATP) has diverse functions as a signaling molecule.
Jeongmin, Choi +7 more
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Apyrases, extracellular ATP and the regulation of growth
Current Opinion in Plant Biology, 2011Although no definitive receptor for extracellular ATP (eATP) has been identified in plants, there is now stronger physiological evidence that the effects of eATP on plant growth are mediated by a receptor, or, as in animals, by multiple receptors. Recent papers clarify how extracellular nucleotides induce changes in [Ca(2+)](cyt), and the production of
Greg, Clark, Stanley J, Roux
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Mechanism of human sperm activation by extracellular ATP
American Journal of Physiology-Cell Physiology, 1996We have identified the mechanism whereby extracellular ATP (ATPe) triggers the acrosome reaction in human spermatozoa. This nucleotide opens a ligand-gated ion channel expressed on the sperm plasma membrane. ATPe threshold and 50% effective concentration calculated on the total added ATPe are 0.1 and 2 mM, respectively, corresponding to a free ATP ...
FORESTA, CARLO +3 more
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