Results 61 to 70 of about 302,924 (260)

Cell death and respiration inhibition of tobacco suspension cells under NaCl stress may be mediated by extracellular ATP

四川大学学报. 自然科学版, 2017
In the present work, by using BY-2 tobacco suspension cells, the effect of the extracellular ATP on the cell death and respiration inhibition induced by NaCl stress was studied.
BAI Jing-Yue, FENG Han-Qing, RONG Fu-Hu, LU Li-Na, WANG Qing-Wen, JIA Ling-Yun   +5 more
doaj  

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Acute lung inflammation and ventilator-induced lung injury caused by ATP via the P2Y receptors: an experimental study

Respiratory Research, 2008
Background Extracellular adenosine 5'-triphosphate (ATP) is an endogenous signaling molecule involved in multiple biological phenomena, including inflammation. The effects of extracellular ATP in the lung have not been fully clarified.
Shime Nobuaki, Mizuta Mitsuhiko, Beppu Satoru, Ueno Hiroshi, Hashimoto Soshi, Amaya Fumimasa, Matsuyama Hiroki, Ishizaka Akitoshi, Hashimoto Satoru   +8 more
doaj   +1 more source

Paxillin mediates ATP-induced activation of P2X7 receptor and NLRP3 inflammasome

BMC Biology, 2020
Background Extracellular adenosine triphosphate (ATP), a key danger-associated molecular pattern (DAMP) molecule, is released to the extracellular medium during inflammation by injured parenchymal cells, dying leukocytes, and activated platelets.
Wenbiao Wang, Dingwen Hu, Yuqian Feng, Caifeng Wu, Yunting Song, Weiyong Liu, Aixin Li, Yingchong Wang, Keli Chen, Mingfu Tian, Feng Xiao, Qi Zhang, Weijie Chen, Pan Pan, Pin Wan, Yingle Liu, Huiyao Lan, Kailang Wu, Jianguo Wu   +18 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

The role of extracellular ATP in regulating the functional activity of cells

Сибирский научный медицинский журнал
A search and analysis of scientific articles presented in the databases PubMed, ScienceDirect, Elsevier, eLibrary for 2000–2024 was carried out. The selection criterion was the presence in the articles of information on the concentration of extracellular
V. P. Patrakeeva
doaj   +1 more source

Vascular CD39/ENTPD1 Directly Promotes Tumor Cell Growth by Scavenging Extracellular Adenosine Triphosphate

Neoplasia: An International Journal for Oncology Research, 2011
Extracellular adenosine triphosphate (ATP) is known to boost immune responses in the tumor microenvironment but might also contribute directly to cancer cell death.
Lili Feng, Xiaofeng Sun, Eva Csizmadia, Lihui Han, Shu Bian, Takashi Murakami, Xin Wang, Simon C. Robson, Yan Wu   +8 more
doaj   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Possible Role of Extracellular Nucleotides in Ectopic Ossification of Human Spinal Ligaments

Journal of Pharmacological Sciences, 2008
To reveal the involvement of extracellular nucleotides in the ossification process in ossification of the posterior longitudinal ligament of the spine (OPLL), the mRNA expression profiles of P2 purinoceptors, mechanical stress-induced ATP release, and ...
Toshitada Sawada, Masaki Kishiya, Kouta Kanemaru, Kazuhiko Seya, Toru Yokoyama, Kazumasa Ueyama, Shigeru Motomura, Satoshi Toh, Ken-Ichi Furukawa   +8 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source