Results 71 to 80 of about 481,952 (302)

Simultaneous quantification of 12 different nucleotides and nucleosides released from renal epithelium and in human urine samples using ion-pair reversed-phase HPLC [PDF]

, 2012
Nucleotides and nucleosides are not only involved in cellular metabolism but also act extracellularly via P1 and P2 receptors, to elicit a wide variety of physiological and pathophysiological responses through paracrine and autocrine signalling pathways.
Alberto Contreras-Sanz, BD Gill, C Crawford, Claire M. Peppiatt-Wildman, DR Ferguson, DR Schneider, EM Schwiebert, EW Inscho, EW Inscho, FQ Yang, G Burnstock, G Burnstock, G Burnstock, G Manfredi, G Xu, HA Neufeld, HA Praetorius, HA Praetorius, Hardyal S. Gill, HM Liebich, I Kugelgen von, I Kugelgen von, J Czarnecka, James Malone-Lee, JC Mathies, Jennifer C. Jacoby, JM Buescher, JO Svensson, JR Gever, K Sugaya, Kevin M. G. Taylor, KH Schram, KR Kim, LA Birder, LC Rump, LD Todorov, M Cichna, M Katayama, MA Bailey, N Ozer, N Yamaoka, NS Zur, P Bodin, P Vinas, PD Wilson, R Corriden, RC Calvert, Rebecca E. Birch, RL Cordell, S Tatur, S Wiener, SA Levesque, Scott S. P. Wildman, Toby S. Scott-Ward, V Jankowski, V Kumar, W Yu, Y Cheng, Y Sun, Y Sun, Y Zheng   +60 more
core   +2 more sources

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

In vivo visualization of cardiac extracellular adenosine dynamics and its pharmacological modulation in zebrafish heart failure models

Scientific Reports
Heart failure (HF) remains a major clinical challenge with poor prognosis despite extensive research and established treatments. Extracellular ATP and adenosine (Ado), as damage-associated molecular patterns (DAMPs), contribute to HF pathogenesis through
Phurpa Phurpa, Magdeline E. Carrasco Apolinario, Ryohei Umeda, Shinichiro Kume, Hitoshi Teranishi, Nobuyuki Shimizu, Mengting Shan, Kenshiro Shikano, Tatsuki Kurokawa, Takatoshi Hikida, Toshikatsu Hanada, Yulong Li, Reiko Hanada   +12 more
doaj   +1 more source

Extracellular ATP reduces HIV-1 transfer from immature dendritic cells to CD4⁺ T lymphocytes

Retrovirology, 2008
Background Dendritic cells (DCs) are considered as key mediators of the early events in human immunodeficiency virus type 1 (HIV-1) infection at mucosal sites.
Barat Corinne, Gilbert Caroline, Imbeault Michael, Tremblay Michel J   +3 more
doaj   +1 more source

Activation of Extracellular-signal Regulated Kinase (ERK1/2) by Fluid Shear is Ca\u3csup\u3e2+\u3c/sup\u3e- and ATP-dependent in MC3T3-E1 Osteoblasts [PDF]

, 2008
To determine the role of Ca2+ signaling in activation of the Mitogen-Activated Protein Kinase (MAPK) pathway, we subjected MC3T3-E1 pre-osteoblastic cells to inhibitors of Ca2+ signaling during application of fluid shear stress (FSS).
Duncan, Randall L., Geist, Derik J., Genetos, Damian C., Ke, Hua Zhe, Li, Jiliang, Liu, Dawei, Shao, Ying, Turner, Charles H.   +7 more
core   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

ATP stimulates appetite by enhancing the expression of hypothalamic orexigenic neuropeptides

Molecular Brain
Hypothalamic neuropeptides play a pivotal role in regulating appetite and energy homeostasis. Extracellular ATP, a key signaling molecule in the hypothalamus, is associated with neuronal activity and metabolic processes.
Nayoun Kim, Eun-Kyoung Kim
doaj   +1 more source

Release of extracellular ATP by bacteria during growth [PDF]

BMC Microbiology, 2013
Abstract Background Adenosine triphosphate (ATP) is used as an intracellular energy source by all living organisms. It plays a central role in the respiration and metabolism, and is the most important energy supplier in many enzymatic reactions.
Mempin, Roberto, Tran, Helen, Chen, Connie, Gong, Hao, Kim Ho, Katharina, Lu, Sangwei   +5 more
openaire   +4 more sources

Role of physiological ClC-1 Cl- ion channel regulation for the excitability and function of working skeletal muscle. [PDF]

, 2016
Electrical membrane properties of skeletal muscle fibers have been thoroughly studied over the last five to six decades. This has shown that muscle fibers from a wide range of species, including fish, amphibians, reptiles, birds, and mammals, are all ...
Chen, Tsung-Yu, de Paoli, Frank Vincenzo, Nielsen, Ole Bækgaard, Pedersen, Thomas Holm, Riisager, Anders   +4 more
core   +1 more source