Results 1 to 10 of about 718,961 (267)

Removal of extracellular human amyloid beta aggregates by extracellular proteases in C. elegans

eLife, 2023
The amyloid beta (Aβ) plaques found in Alzheimer’s disease (AD) patients’ brains contain collagens and are embedded extracellularly. Several collagens have been proposed to influence Aβ aggregate formation, yet their role in clearance is unknown.
Elisabeth Jongsma, Anita Goyala, José Maria Mateos, Collin Yvès Ewald   +3 more
doaj   +1 more source

Exposure to Bacteriophages T4 and M13 Increases Integrin Gene Expression and Impairs Migration of Human PC-3 Prostate Cancer Cells

Antibiotics, 2021
The interaction between bacteriophages and integrins has been reported in different cancer cell lines, and efforts have been undertaken to understand these interactions in tumor cells along with their possible role in gene alterations, with the aim to ...
Swapnil Ganesh Sanmukh, Nilton J. Santos, Caroline Nascimento Barquilha, Sérgio Alexandre Alcantara dos Santos, Bruno Oliveira Silva Duran, Flávia Karina Delella, Andrei Moroz, Luis Antonio Justulin, Hernandes F. Carvalho, Sérgio Luis Felisbino   +9 more
doaj   +1 more source

Bacteriophages M13 and T4 Increase the Expression of Anchorage-Dependent Survival Pathway Genes and Down Regulate Androgen Receptor Expression in LNCaP Prostate Cell Line

Viruses, 2021
Wild-type or engineered bacteriophages have been reported as therapeutic agents in the treatment of several types of diseases, including cancer. They might be used either as naked phages or as carriers of antitumor molecules.
Swapnil Ganesh Sanmukh, Nilton José dos Santos, Caroline Nascimento Barquilha, Maira Smaniotto Cucielo, Márcio de Carvalho, Patricia Pintor dos Reis, Flávia Karina Delella, Hernandes F. Carvalho, Sérgio Luis Felisbino   +8 more
doaj   +1 more source

Longevity-Promoting Pathways and Transcription Factors Respond to and Control Extracellular Matrix Dynamics During Aging and Disease

Frontiers in Aging, 2022
Aging is one of the largest risk factors for cancer, type 2 diabetes, osteoarthritis, cardiovascular diseases, and other age-related pathologies. Here, we give a detailed description of the interplay of chronic age-related pathologies with the remodeling
Tinka Vidović, Collin Y. Ewald
doaj   +1 more source

Acellular Extracellular Matrix Scaffolds in Regenerative Medicine: Advances in Decellularization and Clinical Applications. [PDF]

J Funct Biomater
Jin C, Zhang X, Jin Y, Chien PN, Heo CY.
europepmc   +2 more sources

A chronic moderate methionine administration induced hyperhomocysteinemia associated with cardiovascular disease phenotype in the sand rat Psammomys obesus

Folia Histochemica et Cytobiologica, 2022
INTRODUCTION: Cardiovascular diseases were defined as coronary artery, cerebrovascular, or peripheral arterial disease. Hyperhomocysteinemia (Hhcy) is an independent risk factor of cardiovascular diseases, including atherosclerosis.
Fouzia Zerrouk, Billel Chaouad, Adel Ghoul, Naima Chalour, Anissa Moulahoum, Zineb Khiari, Mohamed el Hadi Cherifi, Souhila Aouichat, Karim Houali, Yasmina Benazzoug   +9 more
doaj   +1 more source

Whole organism profiling of the Timp gene family

Matrix Biology Plus, 2023
Tissue inhibitor of metalloproteinases (TIMPs/Timps) are an endogenous family of widely expressed matrisome-associated proteins that were initially identified as inhibitors of matrix metalloproteinase activity (Metzincin family proteases).
David Peeney, Yu Fan, Sadeechya Gurung, Carolyn Lazaroff, Shashikala Ratnayake, Andrew Warner, Baktiar Karim, Daoud Meerzaman, William G. Stetler-Stevenson   +8 more
doaj   +1 more source

Longevity interventions temporally scale healthspan in Caenorhabditis elegans

iScience, 2022
Summary: Human centenarians and longevity mutants of model organisms show lower incidence rates of late-life morbidities than the average population.
Cyril Statzer, Peter Reichert, Jürg Dual, Collin Y. Ewald   +3 more
doaj   +1 more source

MCAM contributes to the establishment of cell autonomous polarity in myogenic and chondrogenic differentiation

Biology Open, 2017
Cell polarity has a fundamental role in shaping the morphology of cells and growing tissues. Polarity is commonly thought to be established in response to extracellular signals.
Artal Moreno-Fortuny, Laricia Bragg, Giulio Cossu, Urmas Roostalu   +3 more
doaj   +1 more source

Dissecting the phenotypic variability of osteogenesis imperfecta

Disease Models & Mechanisms, 2022
Osteogenesis imperfecta (OI) is a heterogeneous family of collagen type I-related diseases characterized by bone fragility. OI is most commonly caused by single-nucleotide substitutions that replace glycine residues or exon splicing defects in the COL1A1
Nadia Garibaldi, Roberta Besio, Raymond Dalgleish, Simona Villani, Aileen M. Barnes, Joan C. Marini, Antonella Forlino   +6 more
doaj   +1 more source