Results 1 to 10 of about 3,714,644 (355)
Effects of extracellular matrix viscoelasticity on cellular behaviour
Nature, 2020 Ovijit Chaudhuri +2 more
exaly +2 more sources
Remodelling the extracellular matrix in development and disease
Nature Reviews Molecular Cell Biology, 2014 Jonathan Chou, Zena Werb
exaly +2 more sources
A Role of Myocardin Related Transcription Factor-A (MRTF-A) in Scleroderma Related Fibrosis. [PDF]
, 2015 In scleroderma (systemic sclerosis, SSc), persistent activation of myofibroblast leads to severe skin and organ fibrosis resistant to therapy. Increased mechanical stiffness in the involved fibrotic tissues is a hallmark clinical feature and a cause of ...
Abraham, D +11 more
core +14 more sources
Removal of extracellular human amyloid beta aggregates by extracellular proteases in C. elegans
eLife, 2023 The amyloid beta (Aβ) plaques found in Alzheimer’s disease (AD) patients’ brains contain collagens and are embedded extracellularly. Several collagens have been proposed to influence Aβ aggregate formation, yet their role in clearance is unknown.
Elisabeth Jongsma +3 more
doaj +1 more source
Molecular Cancer, 2023 The malignant tumor is a multi-etiological, systemic and complex disease characterized by uncontrolled cell proliferation and distant metastasis. Anticancer treatments including adjuvant therapies and targeted therapies are effective in eliminating ...
Zhennan Yuan +8 more
semanticscholar +1 more source
The extracellular matrix and the immune system: A mutually dependent relationship
Science, 2023 For decades, immunologists have studied the role of circulating immune cells in host protection, with a more recent appreciation of immune cells resident within the tissue microenvironment and the intercommunication between nonhematopoietic cells and ...
T. Sutherland, D. Dyer, J. Allen
semanticscholar +1 more source
The Role of the Extracellular Matrix (ECM) in Wound Healing: A Review
Biomimetics, 2022 The extracellular matrix (ECM) is a 3-dimensional structure and an essential component in all human tissues. It is comprised of varying proteins, including collagens, elastin, and smaller quantities of structural proteins.
Robert B. Diller, A. Tabor
semanticscholar +1 more source
Targeting extracellular matrix stiffness and mechanotransducers to improve cancer therapy
Journal of Hematology & Oncology, 2022 Cancer microenvironment is critical for tumorigenesis and cancer progression. The extracellular matrix (ECM) interacts with tumor and stromal cells to promote cancer cells proliferation, migration, invasion, angiogenesis and immune evasion.
Yangfu Jiang +5 more
semanticscholar +1 more source
Antibiotics, 2021 The interaction between bacteriophages and integrins has been reported in different cancer cell lines, and efforts have been undertaken to understand these interactions in tumor cells along with their possible role in gene alterations, with the aim to ...
Swapnil Ganesh Sanmukh +9 more
doaj +1 more source
Nature Communications, 2022 Matrigel, a mouse tumor extracellular matrix protein mixture, is an indispensable component of most organoid tissue culture. However, it has limited the utility of organoids for drug development and regenerative medicine due to its tumor-derived origin ...
Suran Kim +10 more
semanticscholar +1 more source