Results 1 to 10 of about 706,858 (272)

The Role of Cell-Matrix Interactions in Connective Tissue Mechanics [PDF]

, 2021
Living tissue is able to withstand large stresses in everyday life, yet it also actively adapts to dynamic loads. This remarkable mechanical behaviour emerges from the interplay between living cells and their non-living extracellular environment. Here we review recent insights into the biophysical mechanisms involved in the reciprocal interplay between
arxiv   +1 more source

Cells exploit a phase transition to mechanically remodel the fibrous extracellular matrix [PDF]

Journal of the Royal Society Interface 18: 20200823 2021, 2019
Through mechanical forces, biological cells remodel the surrounding collagen network, generating striking deformation patterns. Tethers-tracts of high densification and fiber alignment-form between cells, thinner bands emanate from cell clusters. While tethers facilitate cell migration and communication, how they form is unclear.
arxiv   +1 more source

Multiphase modeling and qualitative analysis of the growth of tumor cords [PDF]

Netw. Heterog. Media, 3(1):43-83, 2008, 2009
In this paper a macroscopic model of tumor cord growth is developed, relying on the mathematical theory of deformable porous media. Tumor is modeled as a saturated mixture of proliferating cells, extracellular fluid and extracellular matrix, that occupies a spatial region close to a blood vessel whence cells get the nutrient needed for their vital ...
arxiv   +1 more source

Mechanical and Systems Biology of Cancer [PDF]

Computational and Structural Biotechnology Journal 2018; vol: 16; pp: 237-245, 2018
Mechanics and biochemical signaling are both often deregulated in cancer, leading to cancer cell phenotypes that exhibit increased invasiveness, proliferation, and survival. The dynamics and interactions of cytoskeletal components control basic mechanical properties, such as cell tension, stiffness, and engagement with the extracellular environment ...
arxiv   +1 more source

Existence and uniqueness of global classical solutions to a two species cancer invasion haptotaxis model [PDF]

, 2017
We consider a haptotaxis cancer invasion model that includes two families of cancer cells. Both families, migrate on the extracellular matrix and proliferate. Moreover the model describes an epithelial-to-mesenchymal-like transition between the two families, as well as a degradation and a self-reconstruction process of the extracellular matrix.
arxiv   +1 more source

The End-to-End Molecular Communication Model of Extracellular Vesicle-based Drug Delivery [PDF]

arXiv, 2022
A closer look at nature has recently brought more interest in exploring and utilizing intra-body communication networks composed of cells as intrinsic, perfectly biocompatible infrastructures to deliver therapeutics. Naturally occurring cell-to-cell communication systems are being manipulated to release, navigate, and take up soluble cell-derived ...
arxiv  

Mechanical cell-matrix feedback explains pairwise and collective endothelial cell behavior in vitro [PDF]

PLoS Comput Biol 10(8): e1003774, 2014, 2013
In vitro cultures of endothelial cells are a widely used model system of the collective behavior of endothelial cells during vasculogenesis and angiogenesis. When seeded in an extracellular matrix, endothelial cells can form blood vessel-like structures, including vascular networks and sprouts.
arxiv   +1 more source

Convergence and positivity of finite element methods for a haptotaxis model of tumoral invasion [PDF]

arXiv, 2020
In this paper, we consider a mathematical model for the invasion of host tissue by tumour cells in a $d$-dimensional bounded domain, $d\leq 3$. This model consists of a system of differential equations describing the evolution of cancer cell density, the extracellular matrix protein density and the matrix degrading enzyme concentration.
arxiv  

Toward a Designable Extracellular Matrix: Molecular Dynamics Simulations of an Engineered Laminin-mimetic, Elastin-like Fusion Protein [PDF]

Biomacromolecules, 2016, 2016
Native extracellular matrices (ECMs), such as those of the human brain and other neural tissues, exhibit networks of molecular interactions between specific matrix proteins and other tissue components. Guided by these naturally self-assembling supramolecular systems, we have designed a matrix-derived protein chimera that contains a laminin globular ...
arxiv   +1 more source

Cell contraction induces long-ranged stress stiffening in the extracellular matrix [PDF]

, 2017
Animal cells in tissues are supported by biopolymer matrices, which typically exhibit highly nonlinear mechanical properties. While the linear elasticity of the matrix can significantly impact cell mechanics and functionality, it remains largely unknown how cells, in turn, affect the nonlinear mechanics of their surrounding matrix.
arxiv   +1 more source