Results 91 to 100 of about 3,243,882 (355)

Extracellular Matrix in Kidney Fibrosis: More Than Just a Scaffold

Journal of Histochemistry and Cytochemistry, 2019
Kidney fibrosis is the common histological end-point of progressive, chronic kidney diseases (CKDs) regardless of the underlying etiology. The hallmark of renal fibrosis, similar to all other organs, is pathological deposition of extracellular matrix ...
R. D. Bülow, P. Boor
semanticscholar   +1 more source

A unified model for Duchenne muscular dystrophy gene involvement in cancer: context‐dependent tumour suppression and oncogenicity

FEBS Open Bio, EarlyView.
We propose a context‐dependent model where the Duchenne muscular dystrophy (DMD) gene acts as a tumour suppressor in aggressive tumours and as an oncogene in less aggressive ones. We propose this model as a unified framework to explain the opposing survival associations with DMD expression and to guide experimental exploration of the dual role of DMD ...
Lee Machado, Leanne Jones, Sonika Divakar, Michael Naidoo, Karen Anthony   +4 more
wiley   +1 more source

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

FEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini, Nicolò Antonelli, Gianluca Molla   +2 more
wiley   +1 more source

Lactoferrin treatment activates acetylcholinesterase, decreasing acetylcholine levels in non‐small cell lung cancer (NSCLC) cell culture supernatants, inhibiting cell survival

FEBS Open Bio, EarlyView.
Representation of the suggested mode of action of lactoferrin (Lf) in nonsmall cell lung cancer (NSCLC) A549 cells. Lf induces activation of caspase‐3 by activating p53 and AChE leading to decreased ACh concentrations. In turn, ACh signaling leads to activation of VEGF and AKT and blocking of caspase‐3.
Stuti Goel, Caroline Wozniak, Aya Sabri, Ben Haddad, Brooke Lopo, Alvaro Cobos, Sarah Sarofim, Jeffrey Guthrie, Deborah Heyl, Hedeel Guy Evans   +9 more
wiley   +1 more source

Hic-5 antisense oligonucleotide inhibits advanced hepatic fibrosis and steatosis in vivo

JHEP Reports
Background & Aims: Chronic liver diseases, including metabolic dysfunction-associated steatohepatitis (MASH), pose a significant global health burden.
Masahito Noguchi, Aya Miyauchi, Yoshiaki Masaki, Masashi Sakaki, Xiao-Feng Lei, Momoko Kobayashi-Tanabe, Akira Miyazaki, Takeshi Aoki, Hitoshi Yoshida, Kohji Seio, Joo-ri Kim-Kaneyama   +10 more
doaj   +1 more source

The Role of the Extracellular Matrix in Cancer Stemness

Front. Cell Dev. Biol., 2019
As our understanding of cancer cell biology progresses, it has become clear that tumors are a heterogenous mixture of different cell populations, some of which contain so called “cancer stem cells” (CSCs).
S. Nallanthighal, J. P. Heiserman, Dong-Joo Cheon   +2 more
semanticscholar   +1 more source

Indoleamine 2,3‐dioxygenase 1 inhibition reverses cancer‐associated fibroblast‐mediated immunosuppression in high‐grade serous ovarian cancer

FEBS Open Bio, EarlyView.
CAF‐mediated immunosuppression in ovarian cancer is driven by IDO1, reducing T‐cell function. Inhibiting IDO1 restores T‐cell proliferation and cytotoxicity, increases cancer cell apoptosis, and may help overcome CAF‐induced immune suppression in high‐grade serous ovarian cancer. Targeting IDO1 may improve antitumor immunity.
Hyewon Lee, Jung Yoon Ho, In Sun Hwang, Youn Jin Choi   +3 more
wiley   +1 more source

The extracellular matrix: Structure, composition, age-related differences, tools for analysis and applications for tissue engineering

Journal of Tissue Engineering, 2014
The extracellular matrix is a structural support network made up of diverse proteins, sugars and other components. It influences a wide number of cellular processes including migration, wound healing and differentiation, all of which is of particular ...
Jaspreet K Kular, Shouvik Basu, Ram I Sharma   +2 more
doaj   +1 more source

Zearalenone-14-Glucoside Is Hydrolyzed to Zearalenone by β-Glucosidase in Extracellular Matrix to Exert Intracellular Toxicity in KGN Cells [PDF]

, 2022
Haonan Ruan, Yunyun Wang, Yong Hou, Jing Zhang, Jiashuo Wu, Fangqing Zhang, Ming Sui, Jiaoyang Luo, Meihua Yang   +8 more
openalex   +1 more source

The impact of decellularization methods on extracellular matrix derived hydrogels

Scientific Reports, 2019
Tissue-derived decellularized biomaterials are ideal for tissue engineering applications as they mimic the biochemical composition of the native tissue. These materials can be used as hydrogels for cell encapsulation and delivery.
Julia Fernández-Pérez, M. Ahearne
semanticscholar   +1 more source