Results 111 to 120 of about 848,932 (314)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Pathogenic hypothalamic extracellular matrix promotes metabolic disease

Metabolic diseases such as obesity and type 2 diabetes are marked by insulin resistance1,2. Cells within the arcuate nucleus of the hypothalamus (ARC), which are crucial for regulating metabolism, become insulin resistant during the progression of ...
Montgomery, Magdalene K, Karagiannis, Chris, Beddows, Cait A, Dalal, Sagar, Gregorevic, Paul, Ling, Chang-Chun, Packer, Nicolle H, Loh, Kim, Cho, Ellie, Watt, Matthew J, Yong, V Wee, Shi, Feiyue, Horton, Anna L, Zhang, Ping, et al., Rose, Adam J   +15 more
core   +1 more source

Murine model of high bone mass osteogenesis imperfecta exhibits bone matrix hyper-mineralization, misaligned mineral crystals, and altered osteoblast differentiation

Bone Research
Osteogenesis imperfecta (OI), characterized by bone fragility and low bone mass, is predominantly caused by mutations in type I collagen. High bone mass OI (HBM OI) is a rare form caused by heterozygous missense mutations at the type I procollagen C ...
Aileen M. Barnes, M. Helen Rajpar, Joseph E. Perosky, Stéphane Blouin, Basma Khoury, MaryAnn Weis, Theresa Hefferan, Alberta Derkyi, Gali Guterman-Ram, Ghazal Hedjazi, Kiersten Campbell, Chris Stephan, David R. Eyre, Ryan K. Dale, Peter Fratzl, Kenneth M. Kozloff, Nadja Fratzl-Zelman, Joan C. Marini   +17 more
doaj   +1 more source

Engineering a 3D platform for testis bioengineering: generation and proteomic profiling of decellularized fish testicular scaffolds

Frontiers in Bioengineering and Biotechnology
Decellularization represents a robust strategy for generating biologically derived scaffolds that retain the native architecture and biochemical complexity of the extracellular matrix (ECM), thereby providing a conducive microenvironment for germ cell ...
Ivana Felipe Rosa, Ivana Felipe Rosa, Ivana Felipe Rosa, Beatriz Marques Souza, Lucas Benites Doretto, Lucas Benites Doretto, Maira da Silva Rodrigues, Caroline Nascimento Barquilha, Matheus Naia Fioretto, Luiz Marcos Frediani Portela, José Carlos Souza Vieira, Luis Antonio Justulin, Pedro de Magalhães Padilha, Changwei Shao, Changwei Shao, Rafael Henrique Nóbrega   +15 more
doaj   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

Metal ions and the extracellular matrix in tumor migration

, 2019
In this review, we explore the roles of divalent metal ions in structure and function within the extracellular matrix (ECM), specifically, their interaction with glycosaminoglycans (GAGs) during tumor progression.
Stelling, MP, Johnson, WE, Nicholas P. Farrell, Farrell, NP, Mashid, M, Marjon Mashid, Wyatt E. Johnson, Mauro S. Pavão, Juliana M. Motta, Mariana P. Stelling, Pavão, MS, Motta, JM   +11 more
core   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

Function of Proteoglycans in the Extracellular Matrix.

THE JOURNAL OF THE STOMATOLOGICAL SOCIETY,JAPAN, 1993
Proteoglycans are glycosylated proteins which have cova‐lently attached highly anionic glycosaminoglycans. Many forms of proteoglycans are present In virtually all extracellular matrices of connective tissues. The major biological function of proteoglycans derives from the physicochemical characteristics of the glycosaminoglycan component of the ...
openaire   +4 more sources

Hydrostatic pressure activates HIF‐1α via β‐catenin to promote stemness in breast cancer cells

FEBS Open Bio, EarlyView.
To mimic the elevated intestinal fluid pressure in breast cancers, we loaded human breast cancer cells (MCF‐7, MDA‐MB‐453, and BT‐474) to 50 mmHg hydrostatic pressure. Hydrostatic pressure exposure upregulated HIF‐1α and induced stemness in MCF‐7 and BT‐474 cells.
Da Zhai, Yong Xu, Jingjing Ma, Ratchanee Duangrat, Chen Yan, Jingyan Liang, Hua Wei, Bin Jiang, Tao‐Sheng Li   +8 more
wiley   +1 more source