Results 121 to 130 of about 848,932 (314)
, 2016 Background: Epithelial–mesenchymal transition (EMT) is defined as a transformation of tubular epithelial cells into mesenchymal ones. These cells migrate through the extracellular matrix and change into active myofibroblasts, which are responsible for ...
Agnieszka Bargenda +2 more
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Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids
FEBS Open Bio, EarlyView.Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão +3 more
wiley +1 more source
Commentary: Distinct Domains in The Matricellular Protein, Lonely Heart, Are Crucial for Cardiac Extracellular Matrix Formation and Heart Function in Drosophila [PDF]
, 2018 It is well known that cardiovascular diseases are becoming the number one cause of mortality in developed countries1. Minimal differences in a wide range of biological pathways can lead to organ malfunction or failure.
Paululat, Achim, Post, Yanina
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Receptors for extracellular matrix components
, 1989 The extracellular matrix determines the shape and function of multicellular organisms and permits orderly repair after injury. Although the inherent self-assembly properties of many extracellular matrix components such as collagen and elastin foster ...
J. A. McDonald
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Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells
FEBS Open Bio, EarlyView.Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim +4 more
wiley +1 more source
Strengths and opportunities in research into extracellular matrix ageing: A consultation with the ECMage research community [PDF]
Ageing causes progressive decline in metabolic, behavioural, and physiological functions, leading to a reduced health span. The extracellular matrix (ECM) is the three-dimensional network of macromolecules that provides our tissues with structure and ...
Canty‐Laird, Elizabeth G. +11 more
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FEBS Open Bio, EarlyView.IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo +6 more
wiley +1 more source
FEBS Open Bio, EarlyView.The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley +1 more source
, 2009 Freitag S. Behavioral investigation of mice deficient for the extracellular matrix protein tenascin-R and investigation of the influence of maternal separation on the behavior of mice deficient for the cell recognition molecule CHL1. Bielefeld (Germany):
Freitag, Sandra
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