Results 121 to 130 of about 2,626,097 (306)

The extracellular matrix: Structure, composition, age-related differences, tools for analysis and applications for tissue engineering

Journal of Tissue Engineering, 2014
The extracellular matrix is a structural support network made up of diverse proteins, sugars and other components. It influences a wide number of cellular processes including migration, wound healing and differentiation, all of which is of particular ...
Jaspreet K Kular, Shouvik Basu, Ram I Sharma   +2 more
doaj   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Production and degradation of extracellular matrix in reversible glomerular lesions in rat model of habu snake venom-induced glomerulonephritis [PDF]

, 2012
We investigated the mechanism of development and repair process of glomerular injury in a rat model of habu snake (Trimeresurus flavoviridis) venom (HSV)-induced glomerulonephritis. Glomerulonephritis was induced in rats by intravenously injecting HSV at
Miyazaki, Masanobu, Nishino, Tomoya, Furusu, Akira, Kohno, Shigeru, Abe, Katsushige, Koji, Takehiko, Obata, Yoko, Kawazu, Tayo   +7 more
core   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Imbalance in extracellular matrix degradation in urethral stricture

, 2018
Johannes C Prihadi,1 Suwandi Sugandi,2 Nuryati C Siregar,3 Gunanti Soejono,4 Alida Harahap5 1Department of Surgery, Faculty of Medicine, Atma Jaya Catholic University, Jakarta, Indonesia; 2Department of Urology, Faculty of Medicine, Universitas ...
Prihadi JC, Sugandi S, Harahap A, Siregar NC, Soejono G   +4 more
core  

Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk

Molecular Oncology, EarlyView.
Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Verhaltensbiologische Untersuchung Tenascin-R-defizienter Mäuse und Untersuchung des Einflusses einer maternalen Separation auf das Verhalten CHL1-defizienter Mäuse [PDF]

, 2009
Freitag S. Behavioral investigation of mice deficient for the extracellular matrix protein tenascin-R and investigation of the influence of maternal separation on the behavior of mice deficient for the cell recognition molecule CHL1. Bielefeld (Germany):
Freitag, Sandra
core  

Murine model of high bone mass osteogenesis imperfecta exhibits bone matrix hyper-mineralization, misaligned mineral crystals, and altered osteoblast differentiation

Bone Research
Osteogenesis imperfecta (OI), characterized by bone fragility and low bone mass, is predominantly caused by mutations in type I collagen. High bone mass OI (HBM OI) is a rare form caused by heterozygous missense mutations at the type I procollagen C ...
Aileen M. Barnes, M. Helen Rajpar, Joseph E. Perosky, Stéphane Blouin, Basma Khoury, MaryAnn Weis, Theresa Hefferan, Alberta Derkyi, Gali Guterman-Ram, Ghazal Hedjazi, Kiersten Campbell, Chris Stephan, David R. Eyre, Ryan K. Dale, Peter Fratzl, Kenneth M. Kozloff, Nadja Fratzl-Zelman, Joan C. Marini   +17 more
doaj   +1 more source

Engineering a 3D platform for testis bioengineering: generation and proteomic profiling of decellularized fish testicular scaffolds

Frontiers in Bioengineering and Biotechnology
Decellularization represents a robust strategy for generating biologically derived scaffolds that retain the native architecture and biochemical complexity of the extracellular matrix (ECM), thereby providing a conducive microenvironment for germ cell ...
Ivana Felipe Rosa, Ivana Felipe Rosa, Ivana Felipe Rosa, Beatriz Marques Souza, Lucas Benites Doretto, Lucas Benites Doretto, Maira da Silva Rodrigues, Caroline Nascimento Barquilha, Matheus Naia Fioretto, Luiz Marcos Frediani Portela, José Carlos Souza Vieira, Luis Antonio Justulin, Pedro de Magalhães Padilha, Changwei Shao, Changwei Shao, Rafael Henrique Nóbrega   +15 more
doaj   +1 more source