Results 51 to 60 of about 1,191,682 (356)

Smad4 regulates growth plate matrix production and chondrocyte polarity. [PDF]

, 2017
Smad4 is an intracellular effector of the TGFβ family that has been implicated in Myhre syndrome, a skeletal dysplasia characterized by short stature, brachydactyly and stiff joints.
Alliston, Tamara, Berthet, Ellora, Cantu, Andrea, Laird, Diana J, Whitaker, Amanda T   +4 more
core   +3 more sources

From lactation to malignancy: A comparison between healthy and cancerous breast gland at single‐cell resolution reveals new issues for tumorigenesis

FEBS Letters, EarlyView.
Single‐cell RNA sequencing reveals an opposite role of SLPI in basal tumors based on metastatic spread, along with shared activation of specific regulons in cancer cells and mature luminal lactocytes, as well as downregulation of MALAT1 and NEAT1 in the latter.
Pietro Ancona, Carlo M. Bergamini, Carlo Ferrari, Stefano Volinia, Nicoletta Bianchi   +4 more
wiley   +1 more source

Higher hemoglobin levels are associated with adverse heart rate variability in a middle‐aged birth cohort

Physiological Reports
High hemoglobin (Hb) levels within normal variation range are considered beneficial. However, lower Hb levels within normal variation range are associated with healthier cardiovascular traits. Heart rate variability (HRV) and baroreflex sensitivity (BRS)
Samuli Sakko, Mikko. P. Tulppo, Peppi Koivunen, Joona Tapio   +3 more
doaj   +1 more source

Substrate stiffness and VE-cadherin mechano-transduction coordinate to regulate endothelial monolayer integrity. [PDF]

, 2017
The vascular endothelium is subject to diverse mechanical cues that regulate vascular endothelial barrier function. In addition to rigidity sensing through integrin adhesions, mechanical perturbations such as changes in fluid shear stress can also ...
Andresen Eguiluz, Roberto C, Kaylan, Kerim B, Leckband, Deborah E, Underhill, Gregory H   +3 more
core   +1 more source

Imeglimin attenuates liver fibrosis by inhibiting vesicular ATP release from hepatic stellate cells

FEBS Letters, EarlyView.
Imeglimin, at clinically relevant concentrations, inhibits vesicular ATP accumulation and release from hepatic stellate cells, thereby attenuating purinergic signaling and reducing fibrogenic activation. This mechanism reveals a newly identified antifibrotic action of imeglimin beyond glycemic control.
Seiji Nomura, Lixiang Wang, Nao Hasuzawa, Ayako Nagayama, Sawako Moriyama, Kenji Ashida, Yoshinori Moriyama, Masatoshi Nomura, Ken Yamamoto   +8 more
wiley   +1 more source

Tensin links energy metabolism to extracellular matrix assembly. [PDF]

, 2017
The regulation of integrin function is key to fundamental cellular processes, including cell migration and extracellular matrix (ECM) assembly. In this issue, Georgiadou et al. (2017. J. Cell Biol.
Calderwood, Emmanuel Dornier, Hardie, Hardie, Horton, Jim C. Norman, McCleverty, Muranen, Pankov, Rainero, Rantala, Rowe, Schiller, Singh, Van Obberghen-Schilling, Yamada   +15 more
core   +3 more sources

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Effect of Maternal Hyperglycemia on Fetal Pancreatic Islet Development

Biology
Hyperglycemia during fetal development disturbs extracellular matrix (ECM) synthesis and deposition patterns, which disrupts organogenesis and adult organ function. Although the ECM cooperates in pancreas development, little is known about the effects of
Carina Pereira Dias, Michel Raony Teixeira Paiva de Moraes, Fernanda Angela Correia Barrence, Camila Stephanie Balbino da Silva, Basilio Smuckzec, Fernanda Ortis, Telma Maria Tenório Zorn   +6 more
doaj   +1 more source

Synthesis of extracellular matrix components by human ciliary muscle cells in culture [PDF]

, 1992
The production and spatial organization of connective tissue components in ciliary muscle cell cultures was studied with immunohistochemical and ultrastructural methods.
Baur, A., Lütjen-Drecoll, E., Tamm, Ernst R.   +2 more
core   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source