Results 81 to 90 of about 1,191,682 (356)

Extracellular matrix composition in COPD [PDF]

European Respiratory Journal, 2012
Extracellular matrix (ECM) composition has an important role in determining airway structure. We postulated that ECM lung composition of chronic obstructive pulmonary disease (COPD) patients differs from that observed in smoking and nonsmoking subjects without airflow obstruction.We determined the fractional areas of elastic fibres, type-I, -III and ...
Annoni, R., Lancas, T., Tanigawa, R.Y., Matsushita, M.D., Fernezlian, S.D., Bruno, A., Silva, L.F.F. da, Roughley, P.J., Battaglia, S., Dolhnikoff, M., Hiemstra, P.S., Sterk, P.J., Rabe, K.F., Mauad, T.   +13 more
openaire   +6 more sources

Pyrone-based inhibitors of metalloproteinase types 2 and 3 may work as conformation-selective inhibitors. [PDF]

, 2011
Matrix metalloproteinases are zinc-containing enzymes capable of degrading all components of the extracellular matrix. Owing to their role in human disease, matrix metalloproteinase have been the subject of extensive study.
de Oliveira, César AF, Durrant, Jacob D, McCammon, J Andrew   +2 more
core   +1 more source

Dose‐dependent induction of epithelial‐mesenchymal transition in 3D melanoma models by non‐thermal plasma treatment

Molecular Oncology, EarlyView.
Non‐thermal plasma treatment of melanoma cells induced epithelial‐mesenchymal transition (EMT) in a dose‐dependent fashion. This report highlights the critical need to further investigate potential adverse effects of non‐thermal plasma for cancer therapy and to optimize treatment parameters for clinical translation. Despite the promising results of non‐
Eline Biscop, Edgar Cardenas De La Hoz, Hanne Verswyvel, Joey De Backer, Ho Wa Lau, Angela Privat‐Maldonado, Wim Vanden Berghe, Steve Vanlanduit, Evelien Smits, Annemie Bogaerts, Abraham Lin   +10 more
wiley   +1 more source

Prognostic value of NT-proANP levels on major cardiovascular outcomes in a 31-year follow-up study depends on baseline morbidity

Scientific Reports
In subjects with cardiovascular disease (CVD), higher N-terminal proatrial natriuretic peptide (NT-proANP) are associated with major cardiovascular outcomes, while in subjects without CVDs longitudinal data is largely lacking. Our aim was to assess cross-
Samuli Sakko, Juha Perkiömäki, Antti Ylitalo, Heikki Huikuri, Olavi Ukkola, Peppi Koivunen, Joona Tapio   +6 more
doaj   +1 more source

Analysis of cancer cell line and tissue RNA sequencing data reveals an essential and dark matrisome

Matrix Biology Plus
Extracellular matrix remodeling is a hallmark of tissue development, homeostasis, and disease. The processes that mediate remodeling, and the consequences of such, are the topic of extensive focus in biomedical research.
Joshua A. Rich, Yu Fan, Qingrong Chen, Daoud Meerzaman, William G. Stetler-Stevenson, David Peeney   +5 more
doaj   +1 more source

Evidence that an RGD-dependent receptor mediates the binding of oligodendrocytes to a novel ligand in a glial-derived matrix. [PDF]

, 1988
A simple adhesion assay was used to measure the interaction between rat oligodendrocytes and various substrata, including a matrix secreted by glial cells. Oligodendrocytes bound to surfaces coated with fibronectin, vitronectin and a protein component of
Cardwell, MC, Rome, LH
core  

Fibronectin and Cyclic Strain Improve Cardiac Progenitor Cell Regenerative Potential In Vitro. [PDF]

, 2016
Cardiac progenitor cells (CPCs) have rapidly advanced to clinical trials, yet little is known regarding their interaction with the microenvironment. Signaling cues present in the microenvironment change with development and disease.
Bhutani, Srishti, Christman, Karen L, Davis, Michael E, Fierro, Marcos J, French, Kristin M, Ghosh-Choudhary, Shohini, Johnson, Todd D, Maxwell, Joshua T, Taylor, W Robert   +8 more
core   +2 more sources

Tumor clusters with divergent inflammation and human retroelement expression determine the clinical outcome of patients with serous ovarian cancer

Molecular Oncology, EarlyView.
Analysis of treatment‐naïve high‐grade serous ovarian carcinoma (HGSOC) and control tissues for ERVs, LINE‐1 (L1), inflammation, and immune checkpoints identified five clusters with diverse patient recurrence‐free survivals. An inflammation score was calculated and correlated with retroelement expression, where one novel cluster (Triple‐I) with high ...
Laura Glossner, Markus Eckstein, Christoph Mark, Matthias W. Beckmann, Arndt Hartmann, Pamela L. Strissel, Reiner Strick   +6 more
wiley   +1 more source

HIF2α-dependent Dock4/Rac1-signaling regulates formation of adherens junctions and cell polarity in normoxia

Scientific Reports
Hypoxia-inducible factors (HIF) 1 and 2 regulate similar but distinct sets of target genes. Although HIFs are best known for their roles in mediating the hypoxia response accumulating evidence suggests that under certain conditions HIFs, particularly ...
I. Raykhel, V.-P. Ronkainen, J. Myllyharju, A. Manninen   +3 more
doaj   +1 more source

Interactions between Germ Cells and Extracellular Matrix Glycoproteins during Migration and Gonad Assembly in the Mouse Embryo [PDF]

, 1997
Cells are known to bind to individual extracellular matrix glycoproteins in a complex and poorly understood way. Overall strength of adhesion is thought to be mediated by a combinatorial mechanism, involving adhesion of a cell to a variety of binding ...
Alvarez-Buylla, Chiquoine, Cooke, De Felici, DeFelici, DiMilla, Donovan, ffrench-Constant, Fujimoto, García-Castro, Ginsburg, Gomperts, Goodman, Heasman, Lallier, McClay, McKay, Ozdzenski, Skubitz, Tomaselli, Urven, Wylie, Yurchenco   +22 more
core   +5 more sources