Results 81 to 90 of about 3,243,882 (355)

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

HIF2α-dependent Dock4/Rac1-signaling regulates formation of adherens junctions and cell polarity in normoxia

Scientific Reports
Hypoxia-inducible factors (HIF) 1 and 2 regulate similar but distinct sets of target genes. Although HIFs are best known for their roles in mediating the hypoxia response accumulating evidence suggests that under certain conditions HIFs, particularly ...
I. Raykhel, V.-P. Ronkainen, J. Myllyharju, A. Manninen   +3 more
doaj   +1 more source

α3 Chains of type V collagen regulate breast tumour growth via glypican-1

Nature Communications, 2017
Collagen has a role in cancer and is particularly important for breast cancer. Here the authors show that the expression of α3 type V collagen and one of its receptors- glipican-1- in the same cell, contributes to a deregulated growth of breast cancer ...
Guorui Huang, Gaoxiang Ge, Valerio Izzi, Daniel S. Greenspan   +3 more
doaj   +1 more source

Macrophage-extracellular matrix interactions: Perspectives for tissue engineered heart valve remodeling [PDF]

, 2022
Nikolaos Poulis, Marcy Martin, Simon P. Hoerstrup, Maximilian Y. Emmert, Emanuela S. Fioretta   +4 more
openalex   +1 more source

Extracellular Matrix Alterations in Metastatic Processes

International Journal of Molecular Sciences, 2019
The extracellular matrix (ECM) is a complex network of extracellular-secreted macromolecules, such as collagen, enzymes and glycoproteins, whose main functions deal with structural scaffolding and biochemical support of cells and tissues. ECM homeostasis
M. Paolillo, S. Schinelli
semanticscholar   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Regulation of pituitary hormones and cell proliferation by components of the extracellular matrix

Brazilian Journal of Medical and Biological Research, 2005
The extracellular matrix is a three-dimensional network of proteins, glycosaminoglycans and other macromolecules. It has a structural support function as well as a role in cell adhesion, migration, proliferation, differentiation, and survival.
M. Paez-Pereda, F. Kuchenbauer, E. Arzt, G.K. Stalla   +3 more
doaj   +1 more source

Integrins Modulate Extracellular Matrix Organization to Control Cell Signaling during Hematopoiesis [PDF]

, 2020
Rohan J. Khadilkar, Kevin Y.L. Ho, Bhavya Venkatesh, Guy Tanentzapf   +3 more
openalex   +1 more source

Severe Muscle Deconditioning Triggers Early Extracellular Matrix Remodeling and Resident Stem Cell Differentiation into Adipocytes in Healthy Men [PDF]

, 2022
Corentin Guilhot, Théo Fovet, Pierre Delobel, Manon Dargegen, Bernard J. Jasmin, Thomas Brioche, Angèle Chopard, Guillaume Py   +7 more
openalex   +1 more source