Synucleinopathy alters nanoscale organization and diffusion in the brain extracellular space through hyaluronan remodeling [PDF]
Nature Communications, 2020 The nanoscale organisation of the brain extracellular space can be studied in vivo. Here, the authors investigate how it changes in response to α-synuclein pathology, and identify interactions between microglia and the extracellular matrix.
Federico N. Soria +11 more
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Diffusion in Brain Extracellular Space [PDF]
Physiological Reviews, 2008 Diffusion in the extracellular space (ECS) of the brain is constrained by the volume fraction and the tortuosity and a modified diffusion equation represents the transport behavior of many molecules in the brain. Deviations from the equation reveal loss of molecules across the blood-brain barrier, through cellular uptake, binding, or other mechanisms ...
Eva, Syková, Charles, Nicholson
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Extracellular space preservation aids the connectomic analysis of neural circuits
eLife, 2015 Dense connectomic mapping of neuronal circuits is limited by the time and effort required to analyze 3D electron microscopy (EM) datasets. Algorithms designed to automate image segmentation suffer from substantial error rates and require significant ...
Marta Pallotto +4 more
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Purinergic signaling in cochlear supporting cells reduces hair cell excitability by increasing the extracellular space [PDF]
eLife, 2020 Neurons in developing sensory pathways exhibit spontaneous bursts of electrical activity that are critical for survival, maturation and circuit refinement.
Travis A Babola +3 more
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Oligomeric states of ASC specks regulate inflammatory responses by inflammasome in the extracellular space. [PDF]
Cell Death Discov, 2023 Yu TG +8 more
europepmc +3 more sources
Diffusion in the extracellular space in brain and tumors [PDF]
Physical Biology, 2013 Diffusion of solutes and macromolecules in the extracellular space (ECS) in brain is important for non-synaptic intercellular communication, extracellular ionic buffering, and delivery of drugs and metabolites. Diffusion in tumor ECS is important for delivery of anti-tumor drugs.
A. Verkman
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Rapid volume pulsation of the extracellular space coincides with epileptiform activity in mice and depends on the NBCe1 transporter. [PDF]
J Physiol, 2021 Colbourn R +5 more
europepmc +3 more sources
Unassembled cell wall proteins form aggregates in the extracellular space of Chlamydomonas reinhardtii strain UVM4. [PDF]
Appl Microbiol Biotechnol, 2022 Barolo L +7 more
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Extracellular space diffusion and extrasynaptic transmission
Physiological Research, 2008 The diffusion of neuroactive substances in the extracellular space (ECS) plays an important role in short- and long-distance communication between nerve cells and is the underlying mechanism of extrasynaptic (volume) transmission. The diffusion properties of the ECS are described by three parameters: 1. ECS volume fraction alpha (alpha=ECS volume/total
Lýdia Vargová, Eva Syková
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Modeling Extracellular Field Potentials and the Frequency-Filtering Properties of Extracellular Space [PDF]
Biophysical Journal, 2004 Extracellular local field potentials (LFP) are usually modeled as arising from a set of current sources embedded in a homogeneous extracellular medium. Although this formalism can successfully model several properties of LFPs, it does not account for their frequency-dependent attenuation with distance, a property essential to correctly model ...
Claude Bedard +5 more
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