Results 11 to 20 of about 344,575 (257)
An Isotonic Model of Neuron Swelling Based on Co-Transport of Salt and Water
Membranes, 2023 Neurons spend most of their energy building ion gradients across the cell membrane. During energy deprivation the neurons swell, and the concomitant mixing of their ions is commonly assumed to lead toward a Donnan equilibrium, at which the concentration ...
Reinoud Maex
doaj +1 more source
New Insights into Alzheimer’s Disease: Novel Pathogenesis, Drug Target and Delivery
Pharmaceutics, 2023 Alzheimer’s disease (AD), the most common type of dementia, is characterized by senile plaques composed of amyloid β protein (Aβ) and neurofilament tangles derived from the hyperphosphorylation of tau protein.
Haishu Chen +7 more
doaj +1 more source
Unconventional Pathways of Protein Secretion: Mammals vs. Plants
Frontiers in Cell and Developmental Biology, 2022 In eukaryotes, many proteins contain an N-terminal signal peptide that allows their translocation into the endoplasmic reticulum followed by secretion outside the cell according to the classical secretory system. However, an increasing number of secreted
Elisa Maricchiolo +5 more
doaj +1 more source
Frontiers in Oncology, 2023 ObjectivesTo evaluate whether tumor extracellular volume fraction (fECV) on contrast-enhanced computed tomography (CT) aids in the differentiation between intrahepatic cholangiocarcinoma (ICC) and hepatocellular carcinoma (HCC).MethodsIn this ...
T. Honda +12 more
doaj +1 more source
Frontiers in Neurology, 2021 Interictal spikes (IISs) may result from a disturbance of the intimate functional balance between various neuronal (synaptic and non-synaptic), vascular, and metabolic compartments.
Cristian Arnal-Real +4 more
doaj +1 more source
The Lysosomal Sequestration of Tyrosine Kinase Inhibitors and Drug Resistance
Biomolecules, 2019 The Lysosomal sequestration of weak-base anticancer drugs is one putative mechanism for resistance to chemotherapy but it has never been directly proven. We addressed the question of whether the lysosomal sequestration of tyrosine kinase inhibitors (TKIs)
Eliska Ruzickova +4 more
doaj +1 more source
Thimet Oligopeptidase—A Classical Enzyme with New Function and New Form
Immuno, 2021 Peptidases generate bioactive peptides that can regulate cell signaling and mediate intercellular communication. While the processing of peptide precursors is initiated intracellularly, some modifications by peptidases may be conducted extracellularly ...
Yu Liu +3 more
doaj +1 more source
Extracellular space preservation aids the connectomic analysis of neural circuits
eLife, 2015 Dense connectomic mapping of neuronal circuits is limited by the time and effort required to analyze 3D electron microscopy (EM) datasets. Algorithms designed to automate image segmentation suffer from substantial error rates and require significant ...
Marta Pallotto +4 more
doaj +1 more source
Promotion of Lung Cancer Metastasis by SIRT2‐Mediated Extracellular Protein Deacetylation
Advanced Science, 2023 Acetylation of extracellular proteins has been observed in many independent studies where particular attention has been given to the dynamic change of the microenvironmental protein post‐translational modifications.
Meng Wu +24 more
doaj +1 more source
Frontiers in Cell and Developmental Biology, 2022 Macrophages have a vital role in the immune system through elimination of cell debris and microorganisms by phagocytosis. The activation of macrophages by tumour necrosis factor-α induces expression of extracellular cell-surface vimentin and promotes ...
Divyendu Goud Thalla +6 more
doaj +1 more source