Results 21 to 30 of about 531,252 (314)

Diffusion in the extracellular space in brain and tumors [PDF]

Physical Biology, 2013
Diffusion of solutes and macromolecules in the extracellular space (ECS) in brain is important for non-synaptic intercellular communication, extracellular ionic buffering, and delivery of drugs and metabolites. Diffusion in tumor ECS is important for delivery of anti-tumor drugs.
A. S. Verkman
openaire   +6 more sources

THE EXTRACELLULAR SPACE IN BRAIN TUMOURS [PDF]

Brain, 1970
Louis Bakay
openaire   +4 more sources

An Isotonic Model of Neuron Swelling Based on Co-Transport of Salt and Water

Membranes, 2023
Neurons spend most of their energy building ion gradients across the cell membrane. During energy deprivation the neurons swell, and the concomitant mixing of their ions is commonly assumed to lead toward a Donnan equilibrium, at which the concentration ...
Reinoud Maex
doaj   +1 more source

Unconventional Pathways of Protein Secretion: Mammals vs. Plants

Frontiers in Cell and Developmental Biology, 2022
In eukaryotes, many proteins contain an N-terminal signal peptide that allows their translocation into the endoplasmic reticulum followed by secretion outside the cell according to the classical secretory system. However, an increasing number of secreted
Elisa Maricchiolo, Eleonora Panfili, Andrea Pompa, Francesca De Marchis, Michele Bellucci, Maria Teresa Pallotta   +5 more
doaj   +1 more source

Extracellular volume fraction using contrast-enhanced CT is useful in differentiating intrahepatic cholangiocellular carcinoma from hepatocellular carcinoma

Frontiers in Oncology, 2023
ObjectivesTo evaluate whether tumor extracellular volume fraction (fECV) on contrast-enhanced computed tomography (CT) aids in the differentiation between intrahepatic cholangiocarcinoma (ICC) and hepatocellular carcinoma (HCC).MethodsIn this ...
T. Honda, H. Onishi, H. Fukui, K. Yano, K. Kiso, A. Nakamoto, T. Tsuboyama, T. Ota, M. Tatsumi, S. Tahara, S. Kobayashi, H. Eguchi, N. Tomiyama   +12 more
doaj   +1 more source

New Insights into Alzheimer’s Disease: Novel Pathogenesis, Drug Target and Delivery

Pharmaceutics, 2023
Alzheimer’s disease (AD), the most common type of dementia, is characterized by senile plaques composed of amyloid β protein (Aβ) and neurofilament tangles derived from the hyperphosphorylation of tau protein.
Haishu Chen, Jinan Xu, Hanyuan Xu, Tiancheng Luo, Yihao Li, Ke Jiang, Yangping Shentu, Zhiqian Tong   +7 more
doaj   +1 more source

Nanoscale and functional heterogeneity of the hippocampal extracellular space.

Cell Rep, 2023
Summary: The extracellular space (ECS) and its constituents play a crucial role in brain development, plasticity, circadian rhythm, and behavior, as well as brain diseases.
Grassi D, Idziak A, Lee A, Calaresu I, Sibarita JB, Cognet L, Nägerl UV, Groc L.   +7 more
europepmc   +2 more sources

What Triggers the Interictal Epileptic Spike? A Multimodal Multiscale Analysis of the Dynamic of Synaptic and Non-synaptic Neuronal and Vascular Compartments Using Electrical and Optical Measurements

Frontiers in Neurology, 2021
Interictal spikes (IISs) may result from a disturbance of the intimate functional balance between various neuronal (synaptic and non-synaptic), vascular, and metabolic compartments.
Cristian Arnal-Real, Mahdi Mahmoudzadeh, Mana Manoochehri, Mina Nourhashemi, Fabrice Wallois   +4 more
doaj   +1 more source

Modeling extracellular field potentials and the frequency-filtering properties of extracellular space [PDF]

, 2003
Extracellular local field potentials (LFP) are usually modeled as arising from a set of current sources embedded in a homogeneous extracellular medium.
Alain Destexhe, Amzica, Basser, Braitenberg, Bremer, Bremer, Claude Bédard, Creutzfeldt, Creutzfeldt, Destexhe, Destexhe, Destexhe, Eccles, Helmut Kröger, Hille, Hines, Hodgkin, Johnston, Klee, Klee, Koch, Koch, Miller, Nunez, Peters, Press, Protopapas, Rall, Ranck   +28 more
core   +4 more sources

Imaging of the Entry Pathway of a Cell-Penetrating Peptide-DNA Complex From the Extracellular Space to Chloroplast Nucleoids Across Multiple Membranes in Arabidopsis Leaves. [PDF]

Front Plant Sci, 2021
Each plant cell has hundreds of copies of the chloroplast genome and chloroplast transgenes do not undergo silencing. Therefore, chloroplast transformation has many powerful potential agricultural and industrial applications.
Oikawa K, Tateishi A, Odahara M, Kodama Y, Numata K.   +4 more
europepmc   +2 more sources