Results 21 to 30 of about 344,575 (257)

Response of volume and osmoregulatory kidney function to infusion loading in patients with dopamine-dependent compensation of sepsis-induced hypotension

Zaporožskij Medicinskij Žurnal, 2017
Objective. To study the response of volume and osmoregulatory kidney function to increased volume of extracellular space (IVECS) with dopamine-dependent compensation of sepsis-induced hypotension. Materials and methods. The inclusion criteria involved
V. M. Konovchuk, A. V. Andrushchak
doaj   +1 more source

The Association of Heart Failure and Liver T1 Mapping in Cardiac Magnetic Resonance Imaging

Diagnostics
Background/Objectives: The objective of this study was to investigate the association between congestive heart failure (CHF) and T1 mapping in both liver lobes using cardiac MRI.
Adrian T. Huber, Joanna Bartkowiak, Robin Seitz, Benedikt Bernhard, Martina Boscolo Berto, Giancarlo Spano, Benedikt Wagner, Verena C. Obmann, Lukas Ebner, Inga A. S. Todorski, Michael P. Brönnimann, Kady Fischer, Dominik P. Guensch, Andreas Christe, Annalisa Berzigotti, Lorenz Räber, Tobias Reichlin, Thomas Pilgrim, Fabien Praz, Christoph Gräni, Nicholas Brugger, Alan A. Peters   +21 more
doaj   +1 more source

Test of the 'glymphatic' hypothesis demonstrates diffusive and aquaporin-4-independent solute transport in rodent brain parenchyma

eLife, 2017
Transport of solutes through brain involves diffusion and convection. The importance of convective flow in the subarachnoid and paravascular spaces has long been recognized; a recently proposed ‘glymphatic’ clearance mechanism additionally suggests that ...
Alex J Smith, Xiaoming Yao, James A Dix, Byung-Ju Jin, Alan S Verkman   +4 more
doaj   +1 more source

Altered Tracer Distribution and Clearance in the Extracellular Space of the Substantia Nigra in a Rodent Model of Parkinson's Disease

Frontiers in Neuroscience, 2017
The relationship between extracellular space (ECS) diffusion parameters and brain drug clearance is not well-studied, especially in the context of Parkinson's disease (PD). Therefore, we used a rodent model of PD to explore the distribution and clearance
Yuan Fang, Yanchao Dong, Tao Zheng, Dan Du, Jiexia Wen, Dawei Gao, Lanxiang Liu   +6 more
doaj   +1 more source

Formation of Extracellular Traps - the Effective Mechanism of Organism Protection from Pathogen

Проблемы особо опасных инфекций, 2012
Summarized and analyzed are modern literature data on capability of cells (neutrophils, eosinophils and labrocytes) realizing the mechanisms of innate immunity, to form extracellular traps that capture and kill pathogens by secretion of DNA and ...
A. L. Kravtsov
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Studying the extracellular contribution to the double wave vector diffusion-weighted signal

Current Directions in Biomedical Engineering, 2015
The use of two independent diffusion periods between excitation and acquisition, known as double wave vector (DWV) diffusion-weighting or double diffusion encoding, was proven to yield structural information that it is otherwise not easily available in ...
Ulloa Patricia, Wottschel Viktor, Koch Martin A.   +2 more
doaj   +1 more source

Tumor interstitial fluid formation, characterization and clinical implications

Frontiers in Oncology, 2015
The interstitium, situated between the blood and lymph vessels and the cells, consists of a solid or matrix phase and a fluid phase, together constituting the tissue microenvironment.
Marek eWagner, Helge eWiig
doaj   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Cysteine Cathepsins and Their Extracellular Roles: Shaping the Microenvironment

Cells, 2019
For a long time, cysteine cathepsins were considered primarily as proteases crucial for nonspecific bulk proteolysis in the endolysosomal system. However, this view has dramatically changed, and cathepsins are now considered key players in many important
Eva Vidak, Urban Javoršek, Matej Vizovišek, Boris Turk   +3 more
doaj   +1 more source