Results 21 to 30 of about 5,853,415 (367)

Microglia as hackers of the matrix: sculpting synapses and the extracellular space. [PDF]

Cell Mol Immunol, 2021
Microglia shape the synaptic environment in health and disease, but synapses do not exist in a vacuum. Instead, pre- and postsynaptic terminals are surrounded by extracellular matrix (ECM), which together with glia comprise the four elements of the ...
Crapser JD, Arreola MA, Tsourmas KI, Green KN.   +3 more
europepmc   +2 more sources

Near-Infrared Carbon Nanotube Tracking Reveals the Nanoscale Extracellular Space around Synapses. [PDF]

Nano Lett, 2022
We provide evidence of a local synaptic nano-environment in the brain extracellular space (ECS) lying within 500 nm of postsynaptic densities. To reveal this brain compartment, we developed a correlative imaging approach dedicated to thick brain tissue ...
Paviolo C, Ferreira JS, Lee A, Hunter D, Calaresu I, Nandi S, Groc L, Cognet L.   +7 more
europepmc   +2 more sources

Extracellular Space [PDF]

Definitions, 2020
openaire   +2 more sources

Extracellular space and extracellular matrix

Radiopaedia.org, 2020
J. Feger
openaire   +2 more sources

An Isotonic Model of Neuron Swelling Based on Co-Transport of Salt and Water

Membranes, 2023
Neurons spend most of their energy building ion gradients across the cell membrane. During energy deprivation the neurons swell, and the concomitant mixing of their ions is commonly assumed to lead toward a Donnan equilibrium, at which the concentration ...
Reinoud Maex
doaj   +1 more source

Chronic alcohol consumption alters extracellular space geometry and transmitter diffusion in the brain. [PDF]

Sci Adv, 2020
The alcohol-induced inflammatory response increases the diffusion range of small molecules in the extracellular brain parenchyma. Already moderate alcohol consumption has detrimental long-term effects on brain function.
De Santis S, Cosa-Linan A, Garcia-Hernandez R, Dmytrenko L, Vargova L, Vorisek I, Stopponi S, Bach P, Kirsch P, Kiefer F, Ciccocioppo R, Sykova E, Moratal D, Sommer WH, Canals S.   +14 more
europepmc   +2 more sources

Extracellular volume fraction using contrast-enhanced CT is useful in differentiating intrahepatic cholangiocellular carcinoma from hepatocellular carcinoma

Frontiers in Oncology, 2023
ObjectivesTo evaluate whether tumor extracellular volume fraction (fECV) on contrast-enhanced computed tomography (CT) aids in the differentiation between intrahepatic cholangiocarcinoma (ICC) and hepatocellular carcinoma (HCC).MethodsIn this ...
T. Honda, H. Onishi, H. Fukui, K. Yano, K. Kiso, A. Nakamoto, T. Tsuboyama, T. Ota, M. Tatsumi, S. Tahara, S. Kobayashi, H. Eguchi, N. Tomiyama   +12 more
doaj   +1 more source

New Insights into Alzheimer’s Disease: Novel Pathogenesis, Drug Target and Delivery

Pharmaceutics, 2023
Alzheimer’s disease (AD), the most common type of dementia, is characterized by senile plaques composed of amyloid β protein (Aβ) and neurofilament tangles derived from the hyperphosphorylation of tau protein.
Haishu Chen, Jinan Xu, Hanyuan Xu, Tiancheng Luo, Yihao Li, Ke Jiang, Yangping Shentu, Zhiqian Tong   +7 more
doaj   +1 more source

Unconventional Pathways of Protein Secretion: Mammals vs. Plants

Frontiers in Cell and Developmental Biology, 2022
In eukaryotes, many proteins contain an N-terminal signal peptide that allows their translocation into the endoplasmic reticulum followed by secretion outside the cell according to the classical secretory system. However, an increasing number of secreted
Elisa Maricchiolo, Eleonora Panfili, Andrea Pompa, Francesca De Marchis, Michele Bellucci, Maria Teresa Pallotta   +5 more
doaj   +1 more source

Exploring the Dynamics of Brain Extracellular Space. [PDF]

Biophys J, 2019
Pajevic S.
europepmc   +4 more sources