Results 71 to 80 of about 5,853,415 (367)

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Reducing Extracellular Ca2+ Induces Adenosine Release via Equilibrative Nucleoside Transporters to Provide Negative Feedback Control of Activity in the Hippocampus

Frontiers in Neural Circuits, 2017
Neural circuit activity increases the release of the purine neuromodulator adenosine into the extracellular space leading to A1 receptor activation and negative feedback via membrane hyperpolarization and inhibition of transmitter release.
Rebecca Diez, Magnus J. E. Richardson, Mark J. Wall   +2 more
doaj   +1 more source

Dynamic contrast-enhanced magnetic resonance imaging of the lung reveals important pathobiology in idiopathic pulmonary fibrosis

ERJ Open Research, 2021
Introduction Evidence suggests that abnormalities occur in the lung microvasculature in idiopathic pulmonary fibrosis (IPF). We hypothesised that dynamic contrast-enhanced (DCE)-magnetic resonance imaging (MRI) could detect alterations in permeability ...
Sydney B. Montesi, Iris Y. Zhou, Lloyd L. Liang, Subba R. Digumarthy, Sarah Mercaldo, Nathaniel Mercaldo, Ravi T. Seethamraju, Bruce R. Rosen, Peter Caravan   +8 more
doaj   +1 more source

Assembly of the Inner Perivitelline Layer, a Homo log of the Mammalian Zona Pellucida: An Immunohistochemical and Ultrastructural Study [PDF]

, 2012
The avian inner perivitelline layer (IPVL), a homologous structure to the mammalian zona pellucida, is deposited between the granulosa cells and the oocyte cell membrane during folliculogenesis. The glycoprotein meshwork of the IPVL forms a 3-dimensional
Bausek N., Bramwell R.K., Callebaut I., Daniela Rodler, Dunbar B.S., Epifano O., Fred Sinowatz, Goudet G., Jovine L., Jovine L., King A.S., Kinoshita M., Lefievre L., Litscher E.S., Menkhorst E., Mori M., Mugnier S., Pan J., Rahman M.A., Rahman M.A., Richardson K.C., Sasanami T., Sasanami T., Sasanami T., Sasanami T., Sato T., Sinowatz F., Smith J., Spargo S.C., Stewart S.G., Takeuchi Y., Tomohiro Sasanami, Waclawek M., Wassarman P.M., Wassarman P.M., Wassarman P.M., Wyburn G.M., Wyburn G.M.   +37 more
core   +1 more source

A brief history of nearly EV‐erything – The rise and rise of extracellular vesicles

Journal of Extracellular Vesicles, 2021
Extracellular vesicles (EVs) are small cargo‐bearing vesicles released by cells into the extracellular space. The field of EVs has grown exponentially over the past two decades; this growth follows the realisation that EVs are not simply a waste disposal
Y. Couch, E. Buzás, D. D. Vizio, Y. Gho, P. Harrison, A. Hill, J. Lötvall, G. Raposo, P. Stahl, C. Théry, K. Witwer, David Carter   +11 more
semanticscholar   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

In vivo hydrogen peroxide diffusivity in brain tissue supports volume signaling activity

Redox Biology, 2022
Hydrogen peroxide is a major redox signaling molecule underlying a novel paradigm of cell function and communication. A role for H2O2 as an intercellular signaling molecule and neuromodulator in the brain has become increasingly apparent, with evidence ...
A. Ledo, E. Fernandes, A. Salvador, J. Laranjinha, R.M. Barbosa   +4 more
doaj   +1 more source

Morphogen Transport in Epithelia

, 2006
We present a general theoretical framework to discuss mechanisms of morphogen transport and gradient formation in a cell layer. Trafficking events on the cellular scale lead to transport on larger scales. We discuss in particular the case of transcytosis
B. Houchmandzadeh, D. A. Lauffenburger, F. Jülicher, H. Meinhardt, K. Kruse, M. González-Gaitán, P. Pantazis, S. Morimura, T. Bollenbach   +8 more
core   +1 more source

The involvement of actin, calcium channels and exocytosis proteins in somato-dendritic oxytocin and vasopressin release [PDF]

, 2012
Hypothalamic magnocellular neurons release vasopressin and oxytocin not only from their axon terminals into the blood, but also from their somata and dendrites into the extracellular space of the brain, and this can be regulated independently ...
Leng, Gareth, Ludwig, Mike, Tobin, Vicky
core   +2 more sources

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source