Results 261 to 270 of about 80,278 (294)

Neutrophil extracellular traps in cancer

Seminars in Cancer Biology, 2022
Beyond their well-known functions in the acute phases of the immune response, neutrophils play important roles in the various phases of tumor initiation and progression, through the release of their stored or newly synthesized mediators. In addition to reactive oxygen species, cytokines, chemokines, granule proteins and lipid mediators, neutrophil ...
Leonardo Cristinziano, Luca Modestino, Alessandro Antonelli, Gianni Marone, Hans-Uwe Simon, Gilda Varricchi, Maria Rosaria Galdiero   +6 more
openaire   +3 more sources

Rethinking neutrophil extracellular traps

International Immunopharmacology, 2023
Neutrophils are a major subset of leukocytes in human circulating blood. In some circumstances, neutrophils release neutrophil extracellular traps (NETs). lnitially, NETs were considered to have a strong antibacterial capacity. However, currently, NETs have been shown to have a pivotal impact on various diseases.
Yi Liu, Yu-hua Ma, Jian-wei Yang, Jiang-wei Man, Hua-bin Wang, Yi Li, Cheng Liang, Jin-long Cao, Si-yu Chen, Kun-peng Li, Li Yang   +10 more
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Neutrophil Extracellular Traps Kill Bacteria

Science, 2004
Neutrophils engulf and kill bacteria when their antimicrobial granules fuse with the phagosome. Here, we describe that, upon activation, neutrophils release granule proteins and chromatin that together form extracellular fibers that bind Gram-positive and -negative bacteria. These neutrophil extracellular traps (NETs) degrade virulence factors and kill
Brinkmann, V., Reichard, U., Goosmann, C., Fauler, B., Uhlemann, Y., Weiss, D., Weinrauch, Y., Zychlinsky, A.   +7 more
openaire   +4 more sources

Extracellular neutrophil traps in periodontitis

Journal of Periodontal Research, 2009
Background and Objective:  Chronic periodontitis, the chronic inflammatory disease of the periodontium, is caused by bacteria and is characterized by an influx of neutrophils into the gingival crevice. Recently, a ‘new’ extracellular neutrophil defense mechanism – neutrophil extracellular traps – has been described. However, their role in periodontitis
L, Vitkov, M, Klappacher, M, Hannig, W D, Krautgartner   +3 more
openaire   +2 more sources

Eosinophils: Focus on DNA extracellular traps

Life Sciences, 2022
Eosinophils are multitasking granulocytes with implications for allergies, host response to helminths and, more recently, described roles in immunomodulation, homeostasis and tissue remodeling. Eosinophils secrete their preformed granule proteins by different pathways, especially piecemeal degranulation and cytolysis with granule release.
Glaucia A, Thompson-Souza, Claudia Regina Isaías, Vasconcelos, Josiane S, Neves   +2 more
openaire   +2 more sources

Extracellular traps in kidney disease

Kidney International, 2018
During the past decade the formation of neutrophil extracellular traps (NETs) has been recognized as a unique modality of pathogen fixation (sticky extracellular chromatin) and pathogen killing (cytotoxic histones and proteases) during host defense, as well as collateral tissue damage.
Nakazawa, Daigo, Marschner, Julian A., Platen, Louise, Anders, Hans-Joachim   +3 more
openaire   +2 more sources

Neutrophil Extracellular Traps in Sepsis

Shock, 2014
Sepsis is the leading cause of death in critically ill patients in intensive care units. Early recognition of sepsis and proper therapy are essential to reduce patient mortality. Moreover, treatment options for this deleterious inflammatory response to infection are limited.
Camicia, Gabriela Lorena, Pozner, Roberto Gabriel, de Larrañaga, Gabriela Fernanda   +2 more
openaire   +3 more sources

Neutrophil extracellular traps inhibit osteoclastogenesis

Biochemical and Biophysical Research Communications
Neutrophil extracellular traps (NETs) released by neutrophils upon inflammation or infection, act as an innate immune defense against pathogens. NETs also influence inflammatory responses and cell differentiation in host cells. Osteoclasts, which are derived from myeloid stem cells, are critical for the bone remodeling by destroying bone.
Kento Numazaki, Hiroyuki Tada, Takashi Nishioka, Eiji Nemoto, Kenji Matsushita, Itaru Mizoguchi, Shunji Sugawara   +6 more
openaire   +2 more sources

Neutrophil Extracellular Trap in Human Diseases

2012
NETosis is a unique death pathway that differs from apoptosis and necrosis and depends on the generation of reactive oxygen species (ROS) by NADPH oxidase. During this process, neutrophil extracellular traps (NETs) are created. NETs are extracellular structures composed of chromatin and variety of proteins from cells granules that bind and kill ...
Magdalena, Arazna, Michal P, Pruchniak, Katarzyna, Zycinska, Urszula, Demkow   +3 more
openaire   +2 more sources