Results 281 to 290 of about 319,764 (352)

YKT6 Promotes Bladder Cancer Progression by Stabilizing β‐catenin Through USP7‐Mediated Deubiquitination

Advanced Science, EarlyView.
The SNARE protein YKT6 is upregulated in bladder cancer (BLCA), correlating with poor prognosis. YKT6 promotes tumor proliferation and metastasis by activating Wnt/β‐catenin signaling. It recruits Ubiquitin‐Specific Peptidase 7 (USP7) to deubiquitinate and stabilize β‐catenin, enhancing its nuclear accumulation and driving oncogenic gene expression ...
Sheng Tu, Wenzhi Du, Yongwen Luo, Jiageng Shi, Tianyun Liu, Meng Ji, Kangping Xiong, Siming Chen, Fenfang Zhou, Mingxing Li, Jingtian Yu, Gang Wang, Lingao Ju, Yi Zhang, Yu Xiao, Xinghuan Wang, Kaiyu Qian   +16 more
wiley   +1 more source

Small extracellular vesicle-associated surface protein biomarkers: emerging roles, opportunities, and challenges in diagnostics. [PDF]

Front Bioeng Biotechnol
Pham TTH, Sakamoto H, Hasegawa T, Sakamoto C, Suye SI, Chuang HS.   +5 more
europepmc   +1 more source

A Unique Chimeric RNA: ERCC1‐iASPP Drives Benzo[a]pyrene‐Induced Lung Carcinogenesis via Dual Coding and Non‐Coding Mechanisms

Advanced Science, EarlyView.
The chimeric RNA ERCC1‐iASPP possesses dual coding and non‐coding functions, synergistically accelerating the process of cellular malignant transformation. Abstract Genetic variation at 19q13.3 critically modulates chemical carcinogen‐induced lung carcinogenesis, particularly in mediating the activity of benzo[a]pyrene (B[a]P), a major polycyclic ...
Mingming Shan, Mingyang Xiao, Liang Zhang, Shen Wang, Jiahang Wu, Kang Cao, Yujin Li, Guopei Zhang, Junwei Xie, Xiaobo Lu   +9 more
wiley   +1 more source

Stem cell- and extracellular vesicle-based therapies for perianal fistulizing Crohn's disease: An updated review. [PDF]

World J Gastroenterol
Bhatnagar P, Elhariri S, Burud IAS, Eid N.   +3 more
europepmc   +1 more source

Iron Overload Mediates the Differential Cell Fate of Astrocytes from Neurons and Its Regulatory Mechanisms in Ischemic Stroke

Advanced Science, EarlyView.
Upon ischemia/reperfusion‐induced iron overload condition, neurons and astrocytes exhibit similar oxidative stress changes but opposite alterations in endogenous antioxidant defense mechanisms, leading to divergent ferroptotic outcomes. The iron deposition and neuronal loss are increased within the perilesional cortex of stroke patients ...
Yi Guo, Yue Wang, Yong Ni, Bin Bo, Jinzhi He, Yongming Zhu, Aiping Qin, Xianyong Zhou, Huaping Du, Yuan Liu, Tianyao Wang, Yudu Li, Yibo Zhao, Zengai Chen, Zhipei Liang, Yao Li, Yuan Xu, Huiling Zhang   +17 more
wiley   +1 more source

Erratum to “MicroRNAs won the Nobel Prize. Now, can extracellular vesicles help them become drugs?” [Extracell Vesicle 5 (2025) 100080]

Extracellular Vesicle
Vanessa YiRan Li, Nicole Rosas, Sharon Fleischer, Gordana Vunjak-Novakovic, Ke Cheng   +4 more
doaj   +1 more source

Extracellular vesicle R-Ras is a potential biomarker for human peripheral artery disease. [PDF]

iScience
Wei X, Zaghloul M, Hafezi S, Urano F, Zayed MA, Semenkovich CF.   +5 more
europepmc   +1 more source

Role of alpha-synuclein in the regulation of dopamine neurotransmission in the striatum [PDF]

Chadchankar, Heramb
core  

Auditory Hair Cell Mechanotransduction Channels Dynamically Shape the Mechanical Properties of Their Membrane Environment

Advanced Science, EarlyView.
This work shows, for the first time, that the stereocilia membrane in cochlear hair cells is dynamically regulated by the mechanotransduction channel to impact the membrane mechanical properties. This work provides direct evidence that the opening and closing associated with the MET channel is regulating the membrane viscosity suggesting that the MET ...
Shefin S. George, Anthony J. Ricci
wiley   +1 more source

''Non-Invasive Extracellular Vesicle Biomarkers in Endometriosis, Molecular Signatures Linking Pelvic Inflammation, Oocyte Quality, and IVF Outcomes''. [PDF]

Curr Issues Mol Biol
Voros C, Chatzinikolaou F, Sapantzoglou I, Papadimas G, Polykalas S, Mavrogianni D, Koulakmanidis AM, Athanasiou D, Kanaka V, Kanaka M, Bananis K, Athanasiou A, Athanasiou A, Papapanagiotou I, Vaitsis D, Tsimpoukelis C, Daskalaki MA, Theodora M, Thomakos N, Antsaklis P, Loutradis D, Daskalakis G.   +21 more
europepmc   +1 more source