Results 61 to 70 of about 64,409 (290)

Tetraspanins distinguish separate extracellular vesicle subpopulations in human serum and plasma – Contributions of platelet extracellular vesicles in plasma samples

, 2022
Background: The ability to isolate extracellular vesicles (EVs) from blood is vital in the development of EVs as disease biomarkers. Both serum and plasma can be used, but few studies have compared these sources in terms of the type of EVs that are ...
Lötvall, Jan,, Lötvall, Jan, Karimi, Nasibeh,, Lässer, Cecilia, Dias, T., Dias, Tomás, Tomás Dias, Razieh Dalirfardouei, Jan Lötvall, Lässer, Cecilia,, Dalirfardouei, Razieh, Nasibeh Karimi, Dalirfardouei, Razieh,, Karimi, Nasibeh, Cecilia Lässer   +14 more
core   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Altered biodistribution of deglycosylated extracellular vesicles through enhanced cellular uptake

, 2022
Extracellular vesicles (EVs) from cancer are delivered both proximal and distal organs. EVs are highly glycosylated at the surface where EVs interact with cells and therefore has an impact on their properties and biological functions.
Kosaka, N, Nishida-Aoki, N, Tominaga, N, Ochiya, T   +3 more
core   +2 more sources

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Identification of storage conditions stabilizing extracellular vesicles pre [PDF]

, 2022
Extracellular vesicles (EVs) play a key role in many physiological and pathophysiological processes and hold great potential for therapeutic and diagnostic use.
Hagey, Daniel W., van de Wakker, Simonides I, Görgens, André, Stevens, Molly M, Mamand, Doste R., Ma, Li, Pieter Vader, Sork, Helena, Stevens, Molly M., Vader, Pieter, Jawad Wiklander, Rim, R. Beklem Bostancioglu, Wiklander, Oscar PB, Molly M. Stevens, Zickler, Antje M, Helena Sork, Wenyi Zheng, Xiuming Liang, Rim Jawad Wiklander, Samir EL Andaloussi, Felldin, Ulrika, Mamand, Doste R, Wiklander, Oscar P. B., Lee, Yi, Hagey, Daniel W, Gustafsson, Manuela O., Antje M. Zickler, Li Ma, Yi Lee, Bostancioglu, R. Beklem, Giulia Corso, Mohammad, Dara K, Corso, Giulia, Gustafsson, Manuela O, Holme, Margaret N, Daniel W. Hagey, El Andaloussi, Samir, Zickler, Antje M., Holme, Margaret N., Bostancioglu, R Beklem, André Görgens, Wiklander, Oscar P.B., Ulrika Felldin, Simonides I. van de Wakker, Margaret N. Holme, van de Wakker, Simonides I., Zheng, Wenyi, Oscar P. B. Wiklander, Doste R. Mamand, Mohammad, Dara K., Dara K. Mohammad, Manuela O. Gustafsson, Liang, Xiuming   +52 more
core   +1 more source

Circulating LL37 targets plasma extracellular vesicles to immune cells and intensifies Behçet’s disease severity

Journal of Extracellular Vesicles, 2017
Behçet’s disease (BD) activity is characterised by sustained, over-exuberant immune activation, yet the underlying mechanisms leading to active BD state are poorly defined.
Tamer Kahraman, Gozde Gucluler, Ismail Simsek, Fuat Cem Yagci, Muzaffer Yildirim, Can Ozen, Ayhan Dinc, Mayda Gursel, Lolai Ikromzoda, Tolga Sutlu, Stephen Gay, Ihsan Gursel   +11 more
doaj   +1 more source

Biogenesis of extracellular vesicles (EV): exosomes, microvesicles, retrovirus-like vesicles, and apoptotic bodies [PDF]

Journal of Neuro-Oncology, 2013
Recent studies suggest both normal and cancerous cells secrete vesicles into the extracellular space. These extracellular vesicles (EVs) contain materials that mirror the genetic and proteomic content of the secreting cell. The identification of cancer-specific material in EVs isolated from the biofluids (e.g., serum, cerebrospinal fluid, urine) of ...
Johnny C, Akers, David, Gonda, Ryan, Kim, Bob S, Carter, Clark C, Chen   +4 more
openaire   +2 more sources

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Leveraging extracellular vesicle biology for novel tests and therapeutics for kidney fibrosis

Clinical and Translational Medicine
Kidney fibrosis is mechanistically characterised by tissue injury followed by development of a fibrogenic niche. The fibrogenic niche involves chronic inflammation, vascular rarefaction, glomerulosclerosis, tubular atrophy, interstitial accumulation of ...
Chin‐Ya Sophie Chiang, Andrew J. Kassianos, Helen Grania Healy, Monica Suet Ying Ng   +3 more
doaj   +1 more source

Extracellular Vesicles (EVs) Shape the Leukemic Microenvironment

Blood, 2018
Abstract Background Extracellular Vesicles (EVs) compose a naturally occurring, heterogeneous group of membrane-bound, nano-sized particles shed by all cells. Depending on cellular type, physiological state, and mode of secretion some harbor potent regenerative properties while others have the propensity to induce disease.
Theo Borgovan, Chibuikem Chukwudalu Nwizu, Laura R Goldberg, Mark S Dooner, Sicheng Wen, Mike Deltatto, Lorin Crawford, Peter J. Quesenberry   +7 more
openaire   +1 more source