Results 71 to 80 of about 64,409 (290)

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Tumour-Derived Extracellular Vesicles (EVs): A Dangerous “Message in A Bottle” for Bone [PDF]

International Journal of Molecular Sciences, 2019
Several studies have shown the importance of Extracellular Vesicles (EVs) in the intercellular communication between tumour and resident cells. Through EVs, tumour cells can trigger cell-signalling molecules and shuttle exogenous information to target cells, thus promoting spread of the disease.
Cappariello A., Rucci N.
openaire   +2 more sources

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Plasma EV Proteomics Identifies ECM Remodeling and Inflammatory Proteins LUM and C7 as Candidate Biomarkers in FSHD

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Facioscapulohumeral muscular dystrophy (FSHD) is one of the most debilitating and common muscular dystrophies. Despite its severity, no approved therapy exists for FSHD patients. However, several therapeutic candidates are currently under development, and some have recently entered clinical trials, marking the need for reliable ...
Mustafa Bilal Bayazit, Chiranth K. Nagaraj, Jackson S. Newell, Kim Truc Nguyen, Xilal Y. Rima, Jacob Doon‐Ralls, Eduardo Reátegui, Jeffrey M. Statland, Rabi Tawil, Kevin M. Flanigan, Scott Q. Harper, Nizar Y. Saad   +11 more
wiley   +1 more source

The functional role of soluble proteins acquired by extracellular vesicles

Journal of Extracellular Biology, 2022
Extracellular vesicles (EVs) are lipid bilayer‐enclosed nanosized particles released by all cell types during physiological as well as pathophysiological processes to carry out diverse biological functions, including acting as sources of cellular dumping,
Ana Paula Ramos, Heitor Gobbi Sebinelli, Pietro Ciancaglini, Nicola Rosato, Saida Mebarek, Rene Buchet, José Luis Millán, Massimo Bottini   +7 more
doaj   +1 more source

EV-TRACK: transparent reporting and centralizing knowledge in extracellular vesicle research

Nature Methods, 2017
We argue that the field of extracellular vesicle (EV) biology needs more transparent reporting to facilitate interpretation and replication of experiments. To achieve this, we describe EV-TRACK, a crowdsourcing knowledgebase (http://evtrack.org) that centralizes EV biology and methodology with the goal of stimulating authors, reviewers, editors and ...
van Deun, Jan, Mestdagh, Pieter, Agostinis, Patrizia, Akay, Ozden, Anand, Sushma, Anckaert, Jasper, Andreu Martinez, Zoraida, Baetens, Tine, Beghein, Els, Bertier, Laurence, Berx, Geert, Boere, Janneke, Boukouris, Stephanie, Bremer, Michel, Buschmann, Dominik, Byrd, James B., Casert, Clara, Cheng, Lesley, Cmoch, Anna, Daveloose, Delphine, de Smedt, Eva, Demirsoy, Seyma, Depoorter, Victoria, Dhondt, Bert, Driedonks, Tom A. P., Dudek, Aleksandra, Elsharawy, Abdou, Floris, Ilaria, Foers, Andrew D., Gartner, Kathrin, Garg, Abhishek D., Geeurickx, Edward, Gettemans, Jan, Ghazavi, Farzaneh, Giebel, Bernd, Kormelink, Tom Groot, Hancock, Grace, Helsmoortel, Hetty, Hill, Andrew F., Hyenne, Vincent, Kalra, Hina, Kim, David, Kowal, Joanna, Kraemer, Sandra, Leidinger, Petra, Leonelli, Carina, Liang, Yaxuan, Lippens, Lien, Liu, Shu, Lo Cicero, Alessandra, Martin, Shaun, Mathivanan, Suresh, Mathiyalagan, Prabhu, Matusek, Tamas, Milani, Gloria, Monguio-Tortajada, Marta, Mus, Liselot M., Muth, Dillon C., Nemeth, Andrea, Nolte-'T Hoen, Esther N. M., O'Driscoll, Lorraine, Palmulli, Roberta, Pfaffl, Michael W., Primdal-Bengtson, Bjarke, Romano, Erminia, Rousseau, Quentin, Sahoo, Susmita, Sampaio, Natalia, Samuel, Monisha, Scicluna, Benjamin, Soen, Bieke, Steels, Anneleen, Swinnen, Johannes V., Takatalo, Maarit, Thaminy, Safia, Thery, Clotilde, Tulkens, Joeri, van Audenhove, Isabel, van Der Grein, Susanne, van Goethem, Alan, van Herwijnen, Martijn J., van Niel, Guillaume, van Roy, Nadine, van Vliet, Alexander R., Vandamme, Niels, Vanhauwaert, Suzanne, Vergauwen, Glenn, Verweij, Frederik, Wallaert, Annelynn, Wauben, Marca, Witwer, Kenneth W., Zonneveld, Marijke I., de Wever, Olivier, Vandesompele, Jo, Hendrix, An   +94 more
openaire   +4 more sources

Blood Biomarkers and Surface‐Enhanced Raman Spectroscopy for Gout: A Comprehensive Review

Advanced Functional Materials, EarlyView.
Schematic illustrating gout disease progression from asymptomatic hyperuricemia to chronic tophaceous disease, highlighting the limitations of conventional imaging and biochemical diagnostics and the potential of engineered SERS platforms for ultrasensitive blood‐based detection of urate‐related biomarkers across disease stages, with the color gradient
Isuri Perera, Chiranjeevi Kanike, Appurva Tiwari, Hongyan Wu, Larry D. Unsworth, Ben Bin Xu, Xuehua Zhang   +6 more
wiley   +1 more source

The role of Extracellular Vesicles (EVs) in Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Lobar Degeneration (FTLD)

, 2021
ALS and FTLD are neurodegenerative diseases characterized by pathological ubiquitinated and phosphorilated inclusions in the cytosol of affected cells. In 98% of ALS and in the majority of Tau-negative FTLD cases the main component is the TAR DNA-binding
Fabrizio Fabbiano, Angelo Poletti, Maria Cristina Gagliani, Mariarita Galbiati, Cristina Cereda, Stella Gagliardi, Eleonora Corridori, Marta Chierichetti, Elena Casarotto, Daisy Sproviero, Katia Cortese, Paola Rusmini, Marta Cozzi, Barbara Tedesco, Veronica Ferrari, Vito D'agostino, Riccardo Cristofani, Valeria Crippa   +17 more
core  

TPI1-reduced extracellular vesicles mediated by Rab20 downregulation promotes aerobic glycolysis to drive hepatocarcinogenesis

, 2021
Rab GTPases are major mediators that ensure the proper spatiotemporal regulation of intracellular trafficking. Functional impairment and altered expression of Rab proteins have been revealed in various human cancers.
Ma, APY, Xu, Y, Mao, X, Yeung, CLS, Yam, JWP, Liu, BHM, Fung, EYM, Wong, SWK, Tan, KV, Khong, PL, Tey, SK, Yao, Y, Cai, SH, Ng, TH, Yun, JP, Ho, DWH, Ng, IOL, Tang, AHN   +17 more
core   +1 more source

Presentation of antigen on extracellular vesicles using transmembrane domains from viral glycoproteins for enhanced immunogenicity [PDF]

, 2022
A vaccine antigen, when launched as DNA or RNA, can be presented in various forms, including intracellular, secreted, membrane-bound, or on extracellular vesicles (EVs).
Adrian Najer, Najer, Adrian, Junyi Che, Paul F. McKay, Karnyart Samnuan, Blakney, Anna K, Anna K. Blakney, Che, Junyi, Molly M. Stevens, Gwen O'Driscoll, O'Driscoll, Gwen, Hu, Kai, Stevens, Molly M, Cihova, Martina, Robin J. Shattock, Martina Cihova, Kai Hu, McKay, Paul F, Samnuan, Karnyart, Shattock, Robin J   +19 more
core   +1 more source